Early access
Sign in
Taking people in United StatesNo phase

Comparing Steroid Injection Sites for Pain From Knee Osteoarthritis

Compares steroid injections given inside versus outside the knee for inner knee osteoarthritis pain.

Key facts

Who runs it
University of Chicago
Where
Bolingbrook, Chicago, La Grange, Orland Park, and Woodridge, United StatesSee the 5 sites
Trial code
Registry title
Patient Pain and Function in Medial Knee Osteoarthritis After Anteromedial vs Anterolateral Intra-Articular Corticosteroid Injection
Status
Recruiting
People taking part
140 people, planned
Started
31 Aug 2026
Expected to end
1 May 2027
Type of study
Interventional, 2 groupsOne group gets an existing treatment, for comparison.
Treatments tested
  • Anteromedial Injection
  • Anterolateral Injection
Record updated
4 September 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with arthritis (osteoarthritis) mainly on the inner side of the knee who are about to get a steroid injection in the knee. It compares giving the injection on the inner or outer side of the knee.

Age
40 years or older
Sex
All sexes
Disease stage
Knee osteoarthritis with symptoms mainly on the inner (medial) side. X-rays must show moderate-to-severe arthritis there (KL grade 3-4 or equivalent).
Earlier treatment
People must have agreed to get a steroid injection (CSI) in the knee from their surgeon as part of standard care. Past knee injections are allowed. People who already had a knee replacement in this knee cannot join.

Main reasons for not taking part

  • Arthritis mainly on the outer side of the knee, or only behind the kneecap
  • Inflammatory arthritis, such as RA or a gout flare
  • Suspected or confirmed joint infection, or skin infection (cellulitis) over the knee
  • Knee surgery planned for this knee within the 12-week follow-up
  • Unable to complete follow-ups by phone, email or MyChart in English, or another medical reason not to have the injection

The registry criteria, word for word

Show all 13 criteriaShow less

Who can take part

  • Age ≥ 40
  • Clinical diagnosis of knee OA with predominant medial compartment symptoms
  • Radiographic moderate-to-severe medial compartment OA (KL grade 3-4 or equivalent)
  • Agreed to and preparing to receive a CSI of the knee as part of standard care from surgeon, regardless of past injection of the knee
  • Able to provide informed consent
  • Able to complete phone, email, or MyChart follow-ups in English

Who cannot take part

  • Prior knee arthroplasty on the index knee
  • Planned surgery for index knee within 12-week follow-up
  • Suspected or confirmed joint infection or overlying cellulitis
  • Predominant lateral compartment OA or patellofemoral-only OA
  • Inflammatory arthritis (RA, gout flare, etc.)
  • Inability to complete follow-up assessments
  • Other clinician-determined contraindication to CSI

Where in United States

  • Bolingbrook ClinicBolingbrook, United StatesContact: Brandon Pardi, M.D.Taking people
  • Hyde Park ClinicChicago, United StatesContact: Sara J Wallace, M.D./M.P.H.Taking people
  • La Grange ClinicLa Grange, United StatesContact: Sara JS Wallace, M.D./M.P.H.Taking people
  • Orland Park ClinicOrland Park, United StatesContact: Sara JS Wallace, M.D./M.P.H.Taking people
  • Woodridge ClinicWoodridge, United StatesContact: Brandon Pardi, M.D.Taking people

About the trial

What the trial wants to find out

The primary purpose of this study is to find out if there is a difference in pain experienced in patients with knee arthritis of the inside of their knee if they get a steroid injection on the inside or outside of their knee. Participants will:

Read full original descriptionShow less

1. Be randomly divided into getting their steroid injection on the inside or outside of their knee. 2. Answer a pain survey before their injection as well as over the phone 2 weeks, 6 weeks, and 12 weeks after their injection.

The 2 groups in the trial

  • AnterolateralExisting treatment, for comparison

    These patients will receive their corticosteroid injections on their anterolateral knees.

    Treatment: Anterolateral Injection

  • AnteromedialExisting treatment, for comparison

    This group of patients will receive injections on the anteromedial side of their knee.

    Treatment: Anteromedial Injection

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Does Injection Site (Anteromedial vs Anterolateral) Affect Pain Relief After Intra-Articular Corticosteroid Injection in Moderate-to-Severe Medial Knee Osteoarthritis?
Plain-language title
Comparing Steroid Injection Sites for Pain From Knee OsteoarthritisGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 14 November 2026.
Record updated
4 September 2026