Brain light imaging and lurasidone in people with depression from bipolar disorder
Looks at brain energy activity before and after lurasidone in bipolar depression.
Plain-language title generated from the registry record
Registry title: Broadband Near Infrared Spectroscopy to Understand the Role of Brain Cytochrome C Oxidase in Bipolar Disorder
Key facts
- Where
- New York, United StatesSee the site
- Phase
- Phase 4
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 60 years old?
Source: NCT07806227, who can take part
Where in United States
- New York State Psychiatric InstituteNew York, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Martin Lan
- Trial code
- NCT07806227
- Record updated
- 8 September 2026
- Original description
People with a diagnosis of bipolar disorder who are depressed will have a light-based imaging of the brain (Near Infrared Spectroscopy) before and after they have treatment for their depression with a standard, approved medication named lurasidone. They will also answer questions about their history, and give blood samples. The goal is to understand the role of mitochondrial activity in bipolar disorder. Healthy volunteers who have never had a psychiatric disorder will have the same procedures, but they will not receive the medication.Read full original descriptionShow less
Broadband Near Infrared Spectroscopy to Elucidate the of Role Cortical Brain Cytochrome C Oxidase Activity in the Pathophysiology of Bipolar Disorder
People with a diagnosis of bipolar disorder who are depressed will have a light-based imaging of the brain (Near Infrared Spectroscopy) before and after they have treatment for their depression with a standard, approved medication named lurasidone. They will also answer questions about their history, and give blood samples. The goal is to understand the role of mitochondrial activity in bipolar disorder. Healthy volunteers who have never had a psychiatric disorder will have the same procedures, but they will not receive the medication.
Inclusion: Diagnosis of bipolar disorder; Having symptoms of depression; Taking less than three medications for bipolar disorder.
Exclusion: Taking any medications that cannot be combined with lurasidone; Any electroconvulsive therapy (ECT) within the last six months; Any drug or alcohol use disorders that are moderate or severe; Any medical problems that are not well treated; Any severe suicidal ideation, or having had a suicide attempt in the last five years; Any psychotic symptoms that have occurred outside of a mood episode; Currently pregnant or planning to become pregnant during the time of the study.