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Knee artery embolization for knee osteoarthritis in people with a history of cancer

Follows people with cancer and painful knee osteoarthritis who have geniculate artery embolization.

Key facts

Who runs it
M.D. Anderson Cancer Center
Where
Houston, United StatesSee the site
Trial code
Registry title
Prospective Observational Study Of Geniculate Artery Embolization For Symptomatic Knee Osteoarthritis In A Cancer Population
Status
Recruiting
People taking part
50 people, planned
Started
26 Aug 2026
Expected to end
30 Jun 2030
Type of study
Observational
Treatments tested
  • SOC (Standard of care)
Record updated
8 September 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with active cancer and painful knee osteoarthritis (joint wear) who are having geniculate artery embolization, a procedure that blocks small blood vessels around the knee. Knee surgery is not an option for them, or they do not want it.

Age
40 years or older, with no upper age limit, if general health allows the procedure.
Sex
All sexes can join.
Disease stage
Mild to severe knee osteoarthritis (Kellgren-Lawrence grade 2-4) on X-rays taken within 6 months of joining. Knee pain of at least 4/10 for 3 months or more. Active cancer (solid tumor or blood cancer) confirmed at MD Anderson Cancer Center.
Earlier treatment
Knee pain must continue despite usual non-surgical care, such as steroid injections, physical therapy and/or pain medicines. People who already had a knee replacement in that knee cannot join.

Main reasons for not taking part

  • Active joint infection or suspected infection in the knee
  • Expected to live less than 6 months
  • Bleeding problems, or reasons the person cannot have an angiography (imaging of blood vessels)
  • Kidney function (GFR) below 30 mL/min/1.73m²
  • Narrowed or blocked leg arteries, or active autoimmune joint disease such as rheumatoid arthritis

The registry criteria, word for word

Show all 14 criteriaShow less

Who can take part

  • Age ≥40 years with no upper age restriction, provided performance status permits procedural candidacy
  • Symptomatic mild-to-severe knee osteoarthritis (Kellgren-Lawrence grade 2-4) on radiographs within 6 months of enrollment
  • Chronic knee pain (NRS ≥4/10) for ≥3 months despite conservative treatment including steroid injections, physical therapy, and/or analgesic medications
  • Inadequate candidate for or refusal of surgical intervention (e.g., total knee arthroplasty) due to cancer-related comorbidities, ongoing treatment, or participants preference
  • Active cancer diagnosis (solid tumor or hematologic malignancy) confirmed at MD Anderson Cancer Center

Who cannot take part

  • Prior knee arthroplasty in the index knee
  • Active joint infection or suspected septic arthritis
  • Peripheral artery disease with stenosis or occlusion of lower extremity vasculature (relative contraindication per SIR standards, given geniculate artery collateral perfusion role)
  • Known active autoimmune/inflammatory arthropathy (e.g., rheumatoid arthritis, psoriatic arthritis)
  • Any medical condition or clinical abnormality that, per investigator judgment, precludes safe participation in and completion of the study
  • GFR <30 mL/min/1.73m²
  • Life expectancy <6 months
  • Coagulopathy or contraindications to angiography
  • Radiographically normal knee joint (KL grade 0-1) - alternative etiologies should be sought

Where in United States

  • UT MD Anderson Cancer CenterHouston, United StatesContact: Nicolas J Cardenas, MDTaking people

About the trial

What the trial wants to find out

To explore associations with demographics/clinical factors; assess trajectories via annual follow-up; evaluate healthcare utilization and barriers; oversample >10-year survivors.

Treatments tested

  • SOC (Standard of care)

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Prospective Observational Study Of Geniculate Artery Embolization For Symptomatic Knee Osteoarthritis In A Cancer Population
Plain-language title
Knee artery embolization for knee osteoarthritis in people with a history of cancerGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 14 November 2026.
Record updated
8 September 2026