Nebulizer Compared With Handheld Inhalers for Ongoing Treatment of COPD
Tests switching to a nebulizer in COPD patients who feel no benefit from inhalers.
Plain-language title generated from the registry record
Registry title: Nebulizer Versus Handheld Maintenance Therapy for Patients With COPD
Key facts
- Where
- Saint Charles and Winston-Salem, United StatesSee the 2 sites
- Phase
- Phase 4
Where in United States
- Midwest Chest Consultants, P.C.Saint Charles, United StatesTaking people
- Southeastern Research CenterWinston-Salem, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- COPD Foundation
- Trial code
- NCT07816835
- Record updated
- 14 September 2026
- Original description
Multi-site, randomized controlled trial to determine whether patients who report NO symptomatic benefit with their maintenance hand-held inhaler(s), benefit upon switching to nebulized therapy using comparable classes of medications.Read full original descriptionShow less
Nebulizer Versus Handheld Maintenance Therapy for Patients With COPD
Multi-site, randomized controlled trial to determine whether patients who report NO symptomatic benefit with their maintenance hand-held inhaler(s), benefit upon switching to nebulized therapy using comparable classes of medications.
Inclusion: > 10 pack-years smoking cigarettes; Diagnosis of COPD based on GOLD Criteria; Patients are clinically stable for the past 4 weeks; Prior Pulmonary function tests showing FEV1 < 50% predicted (either 30 minutes post albuterol or within 2-4 hours after using their maintenance long-acting inhaler) within the past 12 months; Currently using a single pMDI or a single DPI with either LABA/LAMA or LABA/LAMA/ICS therapy for at least one month.
Exclusion: Current diagnosis of other respiratory disease including asthma, treatment with a LABA/LAMA slow mist inhaler or treatment with SABA/SAMA nebulizer medications 3-4 times per day as maintenance therapy; Current diagnosis of dementia or known cognitive impairment; Current impairment in manual dexterity (i.e., severe rheumatoid arthritis, severe tremor, etc); Exacerbation of COPD within the last 2 months; Current use of daily Prednisone as treatment for COPD.