Testing a daily eating window in adults with obesity and prediabetes
Tests limiting daily eating to 9 hours in adults with obesity or prediabetes.
Plain-language title generated from the registry record
Registry title: The Effect of Time-Restricted Eating in 24-hour Metabolic Homeostasis and Diurnal Rhythm
Key facts
- Where
- Cambridge, United KingdomSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 35 and 75 years old?
Source: NCT07820384, who can take part
Where in United Kingdom
- Cambridge Clinical Research CentreCambridge, United KingdomNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Cambridge University Hospitals NHS Foundation Trust
- Trial code
- NCT07820384
- Record updated
- 15 September 2026
- Original description
Time-restricted eating (TRE) is a dietary manipulation that involves restricting food intake to 6-12 h/day with no food intake during the rest of the day. In animals, TRE improves metabolic function without caloric restriction. However, an understanding of the effect of TRE on cardiometabolic health in people is not clear and few studies have evaluated this issue. This study is a randomized controlled trial in people with obesity and prediabetes/insulin resistance. The overall goal of the study is to determine the effect of 9 h TRE for 12 weeks on key metabolic outcomes that are risk factors for cardiovascular disease (CVD): The goal of this study is to answer the following questions: 1) 24-hour metabolic homeostasis 2) 24h diurnal rhythm and appetite regulation.Read full original descriptionShow less
The Effect of Time-Restricted Eating in 24-hour Metabolic Homeostasis and Diurnal Rhythm
Time-restricted eating (TRE) is a dietary manipulation that involves restricting food intake to 6-12 h/day with no food intake during the rest of the day. In animals, TRE improves metabolic function without caloric restriction. However, an understanding of the effect of TRE on cardiometabolic health in people is not clear and few studies have evaluated this issue. This study is a randomized controlled trial in people with obesity and prediabetes/insulin resistance. The overall goal of the study is to determine the effect of 9 h TRE for 12 weeks on key metabolic outcomes that are risk factors for cardiovascular disease (CVD): The goal of this study is to answer the following questions: 1) 24-hour metabolic homeostasis 2) 24h diurnal rhythm and appetite regulation.
Inclusion: willing and able to give informed consent for participation in the study; aged 35-75 years; men and women; body mass index 27-45 kg/m2; fasting plasma glucose 5.6-6.9 mmol/L, or 2h OGTT plasma glucose 7.8-11.1 mmol/L or haemoglobin A1C 39-46 mmol/mol, homeostasis model assessment-insulin resistance (HOMA-IR) score ≥2.73; self-reported habitual eating period ≥ 13 h per day.
Exclusion: use of medications that affect the study outcome measures or increase the risk of study procedures and that cannot be temporarily discontinued (e.g., steroids, alpha- or beta-adrenergic blockers or agonists, etc.); smoking and illegal drug use; gastrointestinal or bariatric surgery (except cholecystectomy and appendectomy); type 1 or 2 diabetes; sleep disorder (individuals with well-controlled sleep apnoea); eating disorder; cancer in last 5 years; conditions that render subject unable to complete all testing procedures (including individuals with known allergies or contraindications to the medications used in this study); shift worker; fasting >12 h/day more than once a week; vegan; > once a week no food intake after ~1800 h; habitually waking up before ~0400 h and sleeping before ~2100 h; unstable weight (>5% change the last 2 months); pregnant or lactating; unable to grant voluntary informed consent or comply with the study instructions; individuals with electromedical devices; prisoners; alcohol abuse.