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Predicting Crohn's Disease Recurrence After Intestinal Surgery

Studies whether a prediction model can forecast Crohn's disease recurrence after bowel surgery in adults.

Key facts

Who runs it: Sixth Affiliated Hospital, Sun Yat-sen University
Where: Guangzhou, ChinaSee the site
Trial code: NCT07824791
Registry title: Prediction of Postoperative Recurrence in Crohn's Disease
Status: Recruiting
People taking part: 250 people, planned
Started: 22 Jul 2025
Expected to end: Jun 2029
Type of study: Observational, 3 groups
Treatments tested: Intestinal Resection
Biospecimen Collection
Record updated: 17 September 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with Crohn's disease who need surgery to remove a diseased part of the bowel. It also includes a control group of people having bowel surgery for other reasons.

Age: 18 Years to 70 Years
Sex: All sexes can join.
Disease stage: Crohn's disease that needs surgery because of narrowing or penetrating disease, or because medicines have failed. The control group needs bowel surgery for conditions such as colorectal tumors or diverticular disease.

Main reasons for not taking part

Crohn's disease diagnosis is uncertain
Clinical history or medical records are substantially incomplete
Control group: also having inflammatory bowel disease, or another rheumatic or autoimmune disease

The registry criteria, word for word

Show all 4 criteriaShow less

Who can take part

Crohn's Disease Cohorts:; Diagnosis of Crohn's disease according to the diagnostic criteria of the Chinese Consensus on Diagnosis and Treatment of Inflammatory Bowel Disease (2018, Beijing); Patients with Crohn's disease who require surgical resection of the diseased intestinal segment because of complications such as stricturing or penetrating disease, or because of failure of medical therapy; Non-IBD Control Cohort:; 1.Patients who require surgical resection of an intestinal segment because of conditions such as colorectal tumors or diverticular disease

Who cannot take part

Crohn's Disease Cohorts:; Uncertain diagnosis of Crohn's disease; Clinical history or medical records are substantially incomplete, making it impossible to determine the time of recurrence or whether postoperative recurrence occurred; Non-IBD Control Cohort:
Coexisting inflammatory bowel disease or other rheumatic or autoimmune diseases
Substantially incomplete clinical history or medical records

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

Are you between 18 and 70 years old?

Where in China

The Sixth Affiliated Hospital, Sun Yat-sen UniversityGuangzhou, ChinaContact: Xiang Gao, MDTaking people

About the trial

What the trial wants to find out

This multicenter prospective observational cohort study aims to develop and validate a multimodal prediction model for postoperative recurrence in patients with Crohn's disease.

Read full original descriptionShow less

Patients with Crohn's disease who undergo intestinal resection will be enrolled and followed after surgery. Residual surgical tissue that would otherwise be discarded, together with routinely collected clinical data and biological samples, will be used for research. Multi-omics analyses, including single-cell transcriptomics and spatial transcriptomics, will be performed to identify biological features associated with postoperative recurrence.

Participants with Crohn's disease will be followed for clinical, endoscopic, and imaging recurrence after surgery. The study will use data from a screening cohort to develop a prediction model and a validation cohort to evaluate the performance of the model. A control group consisting of patients undergoing intestinal resection for conditions such as colorectal tumors or diverticular disease will also be included for comparative molecular analyses.

No treatment will be assigned by the study protocol. All treatment decisions will be made by the treating physicians according to routine clinical practice.

The 3 groups in the trial

Screening Cohort
Patients with Crohn's disease undergoing clinically indicated intestinal resection. Approximately 100 participants will be enrolled in this cohort. Residual surgical tissue, clinical characteristics, biological samples, and multi-omics data will be collected. Participants will be followed after surgery to identify clinical, endoscopic, and imaging recurrence. Data from this cohort will be used to identify molecular features associated with postoperative recurrence and to develop a multimodal prediction model.
Treatment: Intestinal Resection and Biospecimen Collection
Validation Cohort
Patients with Crohn's disease undergoing clinically indicated intestinal resection. Approximately 100 participants will be enrolled in this multicenter validation cohort and followed after surgery. Clinical, endoscopic, imaging, and biological data will be collected to evaluate the predictive performance of the multimodal model developed in the screening cohort.
Treatment: Intestinal Resection and Biospecimen Collection
Non-IBD Control Cohort
Patients without inflammatory bowel disease who undergo clinically indicated intestinal resection for conditions such as colorectal tumors or diverticular disease. Approximately 50 participants will be enrolled. Residual surgical tissue that would otherwise be discarded will be collected for comparative molecular and multi-omics analyses.
Treatment: Intestinal Resection and Biospecimen Collection