How Beta-2 Adrenergic Receptor Gene Variants and Salt Intake Affect Blood Pressure
Studies how B2AR gene forms and salt intake together affect blood pressure.
Plain-language title generated from the registry record
Registry title: Beta-2 Adrenergic Receptor Polymorphic Variants: An Endotype of Salt Sensitive Hypertension (Beta2AR).
Key facts
- Where
- Boston, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 50 years old?
Source: NCT07832942, who can take part
Where in United States
- Brigham and Women's HospitalBoston, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Brigham and Women's Hospital
- Trial code
- NCT07832942
- Record updated
- 22 September 2026
- Original description
All living things are made of building blocks called cells. Genes are the part of cells that contain the instructions which determine important things about you, like your height or hair color, and affect your health. DNA is the material in the cells that makes up your genes and your particular make-up is call your genotype. Changes or differences in a gene (your genotype) may affect your chances of developing a particular disease, or how a person responds to a particular drug. Your genes are passed down from your parents and then passed on to your children. Different forms of certain genes in your body, for example, the B2AR gene, can increase your blood pressure. The form of the gene that could raise your blood pressure is called the risk allele or risk genotype.Read full original descriptionShow less
Beta-2 Adrenergic Receptor Polymorphic Variants: An Endotype of Salt Sensitive Hypertension.
All living things are made of building blocks called cells. Genes are the part of cells that contain the instructions which determine important things about you, like your height or hair color, and affect your health. DNA is the material in the cells that makes up your genes and your particular make-up is call your genotype. Changes or differences in a gene (your genotype) may affect your chances of developing a particular disease, or how a person responds to a particular drug. Your genes are passed down from your parents and then passed on to your children. Different forms of certain genes in your body, for example, the B2AR gene, can increase your blood pressure. The form of the gene that could raise your blood pressure is called the risk allele or risk genotype.
Taking too much salt in your food or drink also can increase your blood pressure. In this research study we want to determine if different forms of the B2AR gene and the level of salt intake act together to cause high blood pressure.
Inclusion: Ages 18-50 years; HTN as defined by the primary physician; on ≤ two anti-hypertensives; normal renal, liver, metabolic, electrolyte, CBC, and thyroid tests.
Exclusion: Pregnancy; renal, neurologic, and cardiac diseases other than HTN; diabetes; secondary HTN as assessed by history, physical examination, screening blood and urine tests; any drug therapy, except for anti-hypertensives and replacement thyroid medication; and no oral contraceptives/implants/ERT within 2 years of study.