Brain activity and thinking tasks in people with early psychosis
Studies thinking tasks and brain waves in people with early psychosis and healthy volunteers.
Key facts
- Who runs it
- University of Minnesota
- Where
- Minneapolis, United StatesSee the 2 sites
- Trial code
- Registry title
- State Representation in Early Psychosis 2
- Status
- Recruiting
- People taking part
- 500 people, planned
- Started
- 15 Oct 2025
- Expected to end
- 30 Jun 2030
- Type of study
- Observational, 2 groups
- Record updated
- 22 September 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for young people with early psychosis, and for healthy volunteers without psychosis or bipolar disorder. It uses interviews, tasks and EEG.
- Age
- 15 to 45 years.
- Sex
- All sexes can join.
- Disease stage
- People with early psychosis: age 35 or younger, or age 36 to 45 with psychotic symptoms starting within the last 5 years. They must be clinically stable and treated as outpatients for at least one month.
- Earlier treatment
- People who took part in significant formal cognitive training programs cannot join.
Main reasons for not taking part
- Previous clinically significant head injury or long unconsciousness
- Severe substance or alcohol use disorder within 3 months
- Major neurological disorder
- Clinical risk of suicidal behavior
- Healthy volunteers with psychotic or bipolar disorder, or a first-degree relative with one
The registry criteria, word for word
Show all 21 criteriaShow less
Who can take part
- All participants:
- Aged between 15 and 45 years
- English proficiency, as determined by staff observation and participant self-report
- Estimated IQ at or above 70, as estimated by cognitive assessments
- Estimated visual acuity at 20/40, as estimated by the visual acuity test; Early Psychosis participants:
- Clinical diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, psychosis NOS, bipolar disorder with psychosis, or major depressive disorder with psychosis
- Age 35 years or younger, or age 36 to 45 years with onset of psychotic symptoms within the previous 5 years
- Achieved clinical stability, defined as outpatient status for at least one month prior to study participation
Who cannot take part
- Previous clinically significant head injury or prolonged unconsciousness, as determined by the investigators
- Meets criteria for severe substance or alcohol use disorder within 3 months of behavioral assessment
- Presence of any major medical condition that, in the opinion of the investigators, would impede participation or put the participant at additional risk
- Presence of a major neurological disorder; Healthy Control participants:
- Meets DSM-5 criteria for psychotic or bipolar disorder
- Has a first-degree family history of psychotic or bipolar disorder
- Presence of a major neurological disorder
- All participants:
- Unable or unwilling to provide informed consent
- Unable to demonstrate adequate decisional capacity, in the judgment of the consenting study staff member
- Illiterate
- Has participated in significant formal cognitive training programs, as determined by the investigators
- Meets criteria for clinical risk of suicidal behavior; Early Psychosis participants:
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 15 and 45 years old?
Where in United States
- University of Minnesota Ambulatory Research CenterMinneapolis, United StatesContact: Grace OwensTaking people
- University of Minnesota Department of PsychologyMinneapolis, United StatesContact: Grace OwensTaking people
About the trial
What the trial wants to find out
This observational study will examine behavioral and electroencephalography measures related to state representation in individuals with early psychosis and healthy control participants.
Read full original descriptionShow less
Participants will complete clinical interviews, self-report measures, cognitive assessments, computerized behavioral tasks, and EEG assessments. The study will evaluate performance and computed parameters from the Translational Orientation Pattern Expectancy task and Translational Bandit Task, along with EEG variables related to cognitive control, reward processing, and neural synchrony.
The study aims to better understand heterogeneity in early psychosis and identify neurocognitive and neurophysiologic markers that may inform future precision psychiatry approaches.
The 2 groups in the trial
- Early Psychosis Participants
Participants with a clinical diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, psychosis NOS, bipolar disorder with psychosis, or major depressive disorder with psychosis. Participants will complete clinical interviews, self-report measures, cognitive/computerized tasks, and EEG assessments.
- Healthy Control Participants
Community control participants without psychotic or bipolar disorder and without a first-degree family history of psychotic or bipolar disorder. Participants will complete clinical interviews, self-report measures, cognitive/computerized tasks, and EEG assessments.
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- State Representation in Early Psychosis 2
- Plain-language title
- Brain activity and thinking tasks in people with early psychosisGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT07834203, who can take part
- Record updated
- 22 September 2026