Two ways of delivering corneal crosslinking for keratoconus or corneal ectasia
Compares pulsed and non-pulsed light crosslinking in people with keratoconus or corneal ectasia.
Key facts
- Who runs it
- Price Vision Group
- Where
- Indianapolis, United StatesSee the site
- Trial code
- Registry title
- Corneal Crosslinking for Treatment of Progressive Keratoconus or Corneal Ectasia
- Status
- Recruiting
- Phase
- Phase 2/3
- People taking part
- 500 people, planned
- Started
- 1 Oct 2025
- Expected to end
- 30 Jun 2031
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Riboflavin 0.1% ophthalmic solution and pulsed light
- Riboflavin 0.1% ophthalmic solution and non-pulsed light
- Record updated
- 25 September 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for people with keratoconus or corneal ectasia (a thinning and bulging of the clear front of the eye). It compares 2 ways of doing corneal crosslinking.
- Age
- 10 Years to 90 Years
- Sex
- All sexes can join.
- Disease stage
- A diagnosis of keratoconus or corneal ectasia. The title says the disease is getting worse (progressive).
Main reasons for not taking part
- Past eye problems in the study eye that could lead to complications, such as herpes infection of the cornea, corneal dystrophy or corneal melt
- Marked scarring of the cornea in the area to be treated
- Past chemical injury or slow healing of the eye surface in the study eye
- Known sensitivity to the study medicine, or significant dry eye or other conditions that may slow healing
- Being pregnant, planning a pregnancy or breastfeeding during the study
The registry criteria, word for word
Show all 8 criteriaShow less
Who can take part
- Diagnosis of keratoconus or corneal ectasia
- Provision of written informed consent
Who cannot take part
- Previous ocular condition in the study eye that may predispose for future complications including history of corneal disease (e.g., herpes simplex, herpes zoster keratitis, recurrent erosion syndrome, corneal melt, corneal dystrophy, etc.)
- Known sensitivity to study medication
- History of chemical injury or delayed epithelial healing in the study eye
- A current condition, including clinically significant dry eyes or use of medications know to induce dry eye symptoms, that, in the treating physician's opinion, would interfere with or prolong epithelial healing
- Clinically significant corneal scarring in the proposed treatment zone
- Pregnancy (including plan to become pregnant) or lactation during the course of the study
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 10 and 90 years old?
Where in United States
- Price Vision GroupIndianapolis, United StatesContact: Marianne Price, PhDTaking people
About the trial
What the trial wants to find out
This randomized study compares 2 variations of corneal crosslinking for treatment of keratoconus or corneal ectasia.
The 2 groups in the trial
- PulsedExisting treatment, for comparison
Treatment with 0.1% riboflavin eye drops and pulsed 18 milliwatt/cm2 ultraviolet A light for 10 minutes
Treatment: Riboflavin 0.1% ophthalmic solution and pulsed light
- Non-pulsedExisting treatment, for comparison
Treatment with 0.1% riboflavin eye drops non-pulsed 9 milliwatt/cm2 ultraviolet A light for 10 minutes
Treatment: Riboflavin 0.1% ophthalmic solution and non-pulsed light
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Corneal Crosslinking for Treatment of Progressive Keratoconus or Ectasia: Randomized Comparison of Pulsed vs. Non-pulsed Treatment
- Plain-language title
- Two ways of delivering corneal crosslinking for keratoconus or corneal ectasiaGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 15 November 2026.
- Fit questions
- Built from NCT07841470, who can take part
- Record updated
- 25 September 2026