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Not yet taking people in United StatesPhase 3

Zenagamtide Compared With Placebo in People With Heart Disease and Excess Weight

Tests zenagamtide against placebo in people with atherosclerotic heart disease and excess weight.

Plain-language title generated from the registry record
Registry title: A Research Study to Look at How Well Zenagamtide Works Compared to Placebo in People With Established Atherosclerotic Cardiovascular Disease and Either Overweight or Obesity

Key facts

Where
Albany, Amarillo, Austin, Avon, Baltimore, Beaumont, Beaver, Beverly Hills, Birmingham, Bossier City, Bountiful, Bowie, Bridgeport, Bristol, Carrollton, Chesterfield, Chula Vista, Cincinnati, Clearwater, Columbia, Conroe, Conyers, Cordele, Corpus Christi, Council Bluffs, Covina, Covington, Crystal River, Dallas, Delray Beach, Detroit, Durham, Fairhope, Fargo, Flint, Fort Mill, Franklin, Gilbert, Gillespie, Glendale, Green Bay, Greenfield, Greensboro, Greenville, Gurnee, Harlingen, Hazel Crest, Hollywood, Houston, Idaho Falls, Iowa City, Jacksonville, Johns Creek, Kansas City, Kingsport, Lakeland, Lancaster, Las Vegas, Layton, Lexington, Lomita, Longview, Los Alamitos, Los Angeles, Louisville, Lufkin, Macon, Maitland, Manassas, Manlius, Maumee, Mesquite, Miami, Miami Lakes, Mobile, Moline, Montgomery, Moore, Morehead City, Moultrie, Mt. Pleasant, Muncie, Myrtle Beach, Naples, Nashville, New Port Richey, New Windsor, New York, Newport, Newport News, Norfolk, Norman, Northridge, Oak Brook, Ocala, Omaha, Oviedo, Palm Beach Gardens, Palm Harbor, Palm Springs, Peachtree City, Pembroke Pines, Peoria, Philadelphia, Portsmouth, Richmond, Riverview, Round Rock, Sacramento, Salem, San Antonio, San Diego, San Dimas, Santa Maria, Schaumburg, Scottsdale, Slidell, Spokane, Springfield, St Louis, Statesville, Sugar Land, Surprise, Tamarac, The Bronx, Tomball, Topeka, Troy, Tucker, Victoria, Vienna, Wellington, West Des Moines, West Valley City, Westfield, Winchester, and Ypsilanti, United StatesSee the 155 sites
Phase
Phase 3

Could this be for you?

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 45 and 64 years old?

Source: NCT07861100, who can take part

Where in United States

  • Javara/Privia Med Grp GA,LLCAlbany, United StatesNo longer taking part
  • PharmaTex ResearchAmarillo, United StatesNo longer taking part
  • Ascension Texas CardiovascularAustin, United StatesNo longer taking part
  • Pinnacle Clinical ResearchAustin, United StatesNo longer taking part
  • American Health Network of Indiana, LLC_Avon_0Avon, United StatesNo longer taking part
  • Ascension Saint Agnes Heart CaBaltimore, United StatesNo longer taking part
  • MedStar Good Samaritan HospBaltimore, United StatesNo longer taking part
  • Metropolitan Cardiology PABeaumont, United StatesNo longer taking part
  • Heritage Valley Medical GroupBeaver, United StatesNo longer taking part
  • National Heart Institute CalBeverly Hills, United StatesNo longer taking part
  • Uni of Alabama at BirminghamBirmingham, United StatesNo longer taking part
  • Grace Research LLCBossier City, United StatesNo longer taking part
  • Progressive Clinical Research UTBountiful, United StatesNo longer taking part
  • Flourish Research - BowieBowie, United StatesNo longer taking part
  • Bridgeport HospitalBridgeport, United StatesNo longer taking part
  • Holston Medical Group PcBristol, United StatesNo longer taking part
  • West Georgia CardiologyCarrollton, United StatesNo longer taking part
  • Clinical Research ProfessionalsChesterfield, United StatesNo longer taking part
  • California Inst Of Renal ResChula Vista, United StatesNo longer taking part
  • Univ of Cincinnati Med CentCincinnati, United StatesNo longer taking part
  • Innovative Research of W FLClearwater, United StatesNo longer taking part
  • Centennial Medical GroupColumbia, United StatesNo longer taking part
  • Javara Inc. / Privia Medical Group Gulf Coast PLLCConroe, United StatesNo longer taking part
  • Cardiovascular Care Center & CRCConyers, United StatesNo longer taking part
  • Hope Clin Res & WellnessConyers, United StatesNo longer taking part
  • Core Clinical TrialsCordele, United StatesNo longer taking part
  • South Texas Clinical ResearchCorpus Christi, United StatesNo longer taking part
  • West Broadway ClinicCouncil Bluffs, United StatesNo longer taking part
  • Valley Clinical TrialsCovina, United StatesNo longer taking part
  • Louisiana Heart CenterCovington, United StatesNo longer taking part
  • Nature Coast Clin Rsrch_Crystal RiverCrystal River, United StatesNo longer taking part
  • Baylor Jack and Jane HamiltonDallas, United StatesNo longer taking part
  • Liberty Research Center_DallasDallas, United StatesNo longer taking part
  • Thyroid Endocrinology & Diabetes PADallas, United StatesNo longer taking part
  • Florida Premier CardiologyDelray Beach, United StatesNo longer taking part
  • Henry Ford Health SystemDetroit, United StatesNo longer taking part
  • Durham Nephrology AssociatesDurham, United StatesNo longer taking part
  • Eastern Shore Rsrch Inst, LLCFairhope, United StatesNo longer taking part
  • Lillestol Research, LLCFargo, United StatesNo longer taking part
  • Elite Research CenterFlint, United StatesNo longer taking part
  • Piedmont Research Partners LLCFort Mill, United StatesNo longer taking part
  • American Health Network of IN LLC_FranklinFranklin, United StatesNo longer taking part
  • Mercy Gilbert Medical CenterGilbert, United StatesNo longer taking part
  • Macoupin Research GroupGillespie, United StatesNo longer taking part
  • Sun City Clinical ResearchGlendale, United StatesNo longer taking part
  • St. Vincent Hosp-Prevea HealthGreen Bay, United StatesNo longer taking part
  • American Health Network of Indiana, LLC_GreenfieldGreenfield, United StatesNo longer taking part
  • Medication Mgmnt, LLC_GrnsboroGreensboro, United StatesNo longer taking part
  • Carolina Nephrology Clinical ResearchGreenville, United StatesNo longer taking part
  • Elevate Clinical ResearchGurnee, United StatesNo longer taking part
  • Forefront Med Res Inst PLLCHarlingen, United StatesNo longer taking part
  • Chicago Medical Research LLCHazel Crest, United StatesNo longer taking part
  • Encore Medical Research LLCHollywood, United StatesNo longer taking part
  • Endocrine And Psychiatry CenterHouston, United StatesNo longer taking part
  • JCCT- Juno NW HoustonHouston, United StatesNo longer taking part
  • Northwest Houston Cardiology, P.A.Houston, United StatesNo longer taking part
  • Primecare Medical GroupHouston, United StatesNo longer taking part
  • Rocky Mountain Diab&Osteo CtrIdaho Falls, United StatesNo longer taking part
  • University of Iowa Prev Inter CtrIowa City, United StatesNo longer taking part
  • Est Cst Inst for Rsrch,JksnvilJacksonville, United StatesNo longer taking part
  • Jacksonville Ctr Clin ResJacksonville, United StatesNo longer taking part
  • NSC Research, IncJohns Creek, United StatesNo longer taking part
  • Clinical Research ConsultantsKansas City, United StatesNo longer taking part
  • The Alliance for Multispecialty Research LLC AMRKansas City, United StatesNo longer taking part
  • Holston Medical Group.Kingsport, United StatesNo longer taking part
  • Clinical Research of Cent FLLakeland, United StatesNo longer taking part
  • First Valley Medical GroupLancaster, United StatesNo longer taking part
  • Palm Research Center Inc-VegasLas Vegas, United StatesNo longer taking part
  • AMR ClinicalLayton, United StatesNo longer taking part
  • The Research Group of Lexington LLCLexington, United StatesNo longer taking part
  • Torrance Clin Res Inst, Inc.Lomita, United StatesNo longer taking part
  • DCOL Ctr for Clin ResLongview, United StatesNo longer taking part
  • Pacific Clinical StudiesLos Alamitos, United StatesNo longer taking part
  • Academic Medical Research InstituteLos Angeles, United StatesNo longer taking part
  • Norton Clinical Research GroupLouisville, United StatesNo longer taking part
  • Texas Inst, Kdny & Endo DisorLufkin, United StatesNo longer taking part
  • GA Arrhythmia Cons & Rsch InstMacon, United StatesNo longer taking part
  • K2 Medical ResearchMaitland, United StatesNo longer taking part
  • Carient Heart and VascularManassas, United StatesNo longer taking part
  • Central New York Clinical Research CNYCRManlius, United StatesNo longer taking part
  • Advanced Med Res MaumeeMaumee, United StatesNo longer taking part
  • PRX ResearchMesquite, United StatesNo longer taking part
  • Flourish Research - North MiamiMiami, United StatesNo longer taking part
  • Life Spring Research Foundation, LLCMiami, United StatesNo longer taking part
  • Oceane 7 Medical & Research Center, Inc.Miami, United StatesNo longer taking part
  • San Marcus Res Clin Miami LakesMiami Lakes, United StatesNo longer taking part
  • Mobile Heart SpecialistsMobile, United StatesNo longer taking part
  • Cardiovascular Associates of AmericaMoline, United StatesNo longer taking part
  • Chambliss Clinical Trials, LLCMontgomery, United StatesNo longer taking part
  • Tekton Research, IncMoore, United StatesNo longer taking part
  • Carteret Medical GroupMorehead City, United StatesNo longer taking part
  • Ukpong Cardiology ServiceMoultrie, United StatesNo longer taking part
  • Accellacare US Inc._SCMt. Pleasant, United StatesNo longer taking part
  • American Health Network of IN LLCMuncie, United StatesNo longer taking part
  • Carolina Health SpecialistsMyrtle Beach, United StatesNo longer taking part
  • Advance Rsch for Hlth Improvement_NaplesNaples, United StatesNo longer taking part
  • MidState Endocrine AssociatesNashville, United StatesNo longer taking part
  • Suncoast Clinical Research, Inc.New Port Richey, United StatesNo longer taking part
  • Mid Hudson Med Res-New WindsorNew Windsor, United StatesNo longer taking part
  • NYU School of MedicineNew York, United StatesNo longer taking part
  • Capital Area Research LLCNewport, United StatesNo longer taking part
  • TPMG Clinical ResearchNewport News, United StatesNo longer taking part
  • Sentara Health Research CenterNorfolk, United StatesNo longer taking part
  • Lynn Institute of NormanNorman, United StatesNo longer taking part
  • Valley Clinical Trials, Inc.Northridge, United StatesNo longer taking part
  • Genesis Orthopedics & Sports MedicineOak Brook, United StatesNo longer taking part
  • Ocala Cardiovascular ResearchOcala, United StatesNo longer taking part
  • University of Nebraska Medical CenterOmaha, United StatesNo longer taking part
  • VA NEB - Western IA Health StmOmaha, United StatesNo longer taking part
  • Oviedo Medical Research, LLCOviedo, United StatesNo longer taking part
  • Cardio Partners Clin Res InstPalm Beach Gardens, United StatesNo longer taking part
  • Suncoast Clinical Research, Inc.Palm Harbor, United StatesNo longer taking part
  • Desert Oasis Hlthcr Med GroupPalm Springs, United StatesNo longer taking part
  • Javara Inc. / Privia Medical Group Georgia LLCPeachtree City, United StatesNo longer taking part
  • Suncoast Research Associates LLCPembroke Pines, United StatesNo longer taking part
  • UnityPoint Health-Diabetes Care CenterPeoria, United StatesNo longer taking part
  • Aria Endocrine Metabolic AssocPhiladelphia, United StatesNo longer taking part
  • Seacoast Kidney & Htn SpecialistsPortsmouth, United StatesNo longer taking part
  • Dominion Medical AssociatesRichmond, United StatesNo longer taking part
  • Florida Kidney Physicians LLCRiverview, United StatesNo longer taking part
  • Ascension Texas CardiovascularRound Rock, United StatesNo longer taking part
  • Clinical Trials Research SacramentoSacramento, United StatesNo longer taking part
  • VA Medical Center_SalemSalem, United StatesNo longer taking part
  • Clinical Advancement CenterSan Antonio, United StatesNo longer taking part
  • Sun Research InstituteSan Antonio, United StatesNo longer taking part
  • The IMA Group IMA Clinical Trials of America Inc. CTASan Antonio, United StatesNo longer taking part
  • Univ Of Texas Hlth Science CntrSan Antonio, United StatesNo longer taking part
  • VIP TrialsSan Antonio, United StatesNo longer taking part
  • Paradigm Clinical ResearchSan Diego, United StatesNo longer taking part
  • N America Res Inst - San DimasSan Dimas, United StatesNo longer taking part
  • FOMAT Medical ResearchSanta Maria, United StatesNo longer taking part
  • Cardiovascular Associates of AmericaSchaumburg, United StatesNo longer taking part
  • Honor HealthScottsdale, United StatesNo longer taking part
  • Louisiana Heart Center - SlidellSlidell, United StatesNo longer taking part
  • Providence Medical Research CenterSpokane, United StatesNo longer taking part
  • Headlands ResearchSpringfield, United StatesNo longer taking part
  • Amicis Centers of Clinical ResearchSt Louis, United StatesNo longer taking part
  • Piedmont Healthcare/ResearchStatesville, United StatesNo longer taking part
  • Houston Research InstituteSugar Land, United StatesNo longer taking part
  • Simcare Medical Research, LLCSugar Land, United StatesNo longer taking part
  • Clinical Research Institute of ArizonaSurprise, United StatesNo longer taking part
  • Care AccessTamarac, United StatesNo longer taking part
  • NYC Health + Hospitals/LincolnThe Bronx, United StatesNo longer taking part
  • Northwest Houston Clinical Research PLLCTomball, United StatesNo longer taking part
  • Cotton O'Neil Diab & Endo CtrTopeka, United StatesNo longer taking part
  • Arcturus Healthcare, PLC.Troy, United StatesNo longer taking part
  • Atlanta Heart SpecialistTucker, United StatesNo longer taking part
  • Crossroads Clinical Res- TexasVictoria, United StatesNo longer taking part
  • Conquest ResearchVienna, United StatesNo longer taking part
  • Cardiovascular Associates of AmericaWellington, United StatesNo longer taking part
  • Iowa Diab & Endo Res CenterWest Des Moines, United StatesNo longer taking part
  • Kalo Clinical ResearchWest Valley City, United StatesNo longer taking part
  • Great Lakes Medical ResearchWestfield, United StatesNo longer taking part
  • Selma Medical AssociatesWinchester, United StatesNo longer taking part
  • Trinity Health Michigan HeartYpsilanti, United StatesNo longer taking part

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?
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Trial details

Who runs it
Novo Nordisk A/S
Trial code
NCT07861100EU 2026-525182-53-00
Record updated
6 October 2026
Original description
This clinical study is being conducted to evaluate the safety and effectiveness of zenagamtide in people with atherosclerotic cardiovascular disease (ASCVD) and excess body weight compared with placebo. The purpose of this clinical study is to find out if zenagamtide is safe and effective for treating people who have ASCVD and excess body weight. Participants will be randomly assigned by chance to receive either zenagamtide, the investigational treatment being tested, or a placebo, which contains no active medicine. Half of the participants will receive zenagamtide, and treatment assignment will be determined randomly. Zenagamtide is a new investigational medicine that is not yet available for prescription by doctors.Read full original descriptionShow less

Zenagamtide Use for the Reduction of Risk of Major Adverse Cardiovascular Events in People With Established Atherosclerotic Cardiovascular Disease and Either Overweight or Obesity

This clinical study is being conducted to evaluate the safety and effectiveness of zenagamtide in people with atherosclerotic cardiovascular disease (ASCVD) and excess body weight compared with placebo. The purpose of this clinical study is to find out if zenagamtide is safe and effective for treating people who have ASCVD and excess body weight. Participants will be randomly assigned by chance to receive either zenagamtide, the investigational treatment being tested, or a placebo, which contains no active medicine. Half of the participants will receive zenagamtide, and treatment assignment will be determined randomly. Zenagamtide is a new investigational medicine that is not yet available for prescription by doctors.

Inclusion: Established ASCVD is defined as at least one of the below conditions (a-c):; Prior myocardial infarction (MI) b. Symptomatic peripheral artery disease (PAD) defined as at least one of the following: i. Intermittent claudication with an ankle-brachial index (ABI) less than (<) 0.85 at rest ii. Lower extremity amputation at or above ankle due to atherosclerotic disease (excluding e.g. trauma or osteomyelitis) c. Cerebrovascular disease defined as the following: i. Prior stroke; Participants with Type 2 Diabetes (T2D) (at screening) are allowed in the study with the following provisions:; Treatment should be stable for greater than or equal to (≥) 90 days before screening as assessed by the investigator; Glucose lowering agents are permitted according to local label except glucagon-like peptide-1 receptor agonist (GLP-1 RA), glucose-dependent insulinotropic polypeptide (GIP) and amylin analogues; for insulins, only basal insulin is allowed.

Exclusion: MI, stroke, unstable angina pectoris, or worsening heart failure (HF) leading to either hospitalization or intravenous loop diuretics within 30 days prior to the day of screening and until randomization; Coronary, carotid, or peripheral artery revascularization or percutaneous valve repair or replacement within 30 days prior to the day of screening or planned during the study period and known at screening; General health and safety:; Treatment with any GLP-1 RA, GIP RA or amylin analogue for any indication before screening; Chronic heart failure classified at screening; Glycaemia-related:; Recurrent severe hypoglycaemic episodes within the last year as judged by the investigator; Known history of hypoglycaemia unawareness as indicated by the investigator according to Clarke's questionnaire question 8; History of type 1 diabetes (T1D); Participant with diabetic retinopathy or maculopathy who received treatment with retinal photocoagulation, vitrectomy or anti-Vascular Endothelial Growth Factor (anti-VEGF) within 180 days before screening or who, at the time of screening, are expected to require treatment within 180 days after screening. Diabetic retinopathy or maculopathy must be verified by an eye examination performed within 90 days before screening or in the period between screening and randomization. Pharmacological pupil-dilation is a requirement unless using a digital fundus photography camera specified for non-dilated examination; Glycated haemoglobin (HbA1c) greater than (>) 10 percentage (%) (86 millimoles per mole [mmol/mol]) as measured by central laboratory at screening.

ClinicalTrials.gov NCT07861100 · EU CTIS 2026-525182-53-00