Compares heart effects of cigarettes and e-cigarettes in older adults with high blood pressure
Compares heart effects of cigarettes and e-cigarettes in older adults with hypertension.
Plain-language title generated from the registry record
Registry title: Cardiovascular Impacts of E-cigarettes Among Older Adults
Key facts
- Where
- Baltimore, United StatesSee the site
Where in United States
- Kahlert Institute for Addiction MedicineBaltimore, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Maryland, Baltimore
- Trial code
- NCT07880704
- Record updated
- 19 October 2026
- Original description
This study will compare the cardiovascular effects of continued smoking with those of e-cigarette (EC) use among older adults with hypertension. Using both laboratory and real-world measurements, this study will be the first to examine the relative cardiovascular impacts of smoking and EC in a patient population at high risk of smoking-related disease progression.Read full original descriptionShow less
Comparison of Cigarette Smoking and E-cigarette Use
This study will compare the cardiovascular effects of continued smoking with those of e-cigarette (EC) use among older adults with hypertension. Using both laboratory and real-world measurements, this study will be the first to examine the relative cardiovascular impacts of smoking and EC in a patient population at high risk of smoking-related disease progression.
Inclusion: Age 50 years or older; Currently smokes 5 or more combustible tobacco cigarettes per day and has smoked at this level for at least 1 year, based on self-report; Expired-air carbon monoxide level ≥8 parts per million (ppm), confirming recent cigarette smoking; Average screening/baseline systolic blood pressure ≥130 mm Hg or average screening diastolic blood pressure ≥80 mm Hg; Able and willing to provide informed consent and complete the study procedures, including in-person visits, two 14-day study periods, daily check-ins, and use of study equipment; If able to become pregnant (confirmed with participant), agree to avoid pregnancy during the study.
Exclusion: Currently seeking or receiving smoking-cessation treatment; Currently taking medication for the treatment of hypertension; Experienced a major medical event, including a cardiovascular event, within the past 6 months, such as myocardial infarction or acute coronary syndrome, stroke or transient ischemic attack, coronary or peripheral revascularization, hospitalization for heart failure; A current unstable cardiovascular condition that, in the judgment of the PI or designated medical clinician, would make participation unsafe; Confirmed severe hypertension at screening: resting systolic blood pressure greater than 180 mm Hg OR diastolic blood pressure greater than 120 mm Hg on repeat assessment; The investigator or medical monitor determines that participation would present an unacceptable medical or safety risk (i.e., current concerning cardiovascular or neurologic symptoms; an acute or uncontrolled medical illness; clinically significant intoxication or withdrawal; a medication or health change likely to make blood pressure, heart rate, or study participation unsafe; inability to safely use the study equipment despite training; or another specific condition that creates a foreseeable risk from continued smoking, e-cigarette exposure, or study procedures); Self-reported consumption of 4 or more standard alcoholic drinks for women or 5 or more for men on any single day during the past 30 days; Self-reported daily nonmedical use of opioids, stimulants, sedatives, cannabis, or another substance; Currently uses another tobacco or nicotine product (e.g., electronic cigarettes or smokeless tobacco) on 2 or more consecutive days during the past month; Pregnancy, as indicated by a positive screening urine pregnancy test conducted for a participant who reports being able to become pregnant.