Multidisciplinary Outpatient Program for Adults With Obesity and Related Health Conditions
Compares a combined diet, exercise and counselling program with usual care in adults with obesity.
Plain-language title generated from the registry record
Registry title: MORPH-A - Multidisciplinary Obesity Rehabilitation & Psychophysical Health and Awareness
Key facts
- Where
- Pavia, ItalySee the site
Where in Italy
- Istituti Clinici Scientifici Maugeri IRCCSPavia, ItalyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Istituti Clinici Scientifici Maugeri SpA
- Trial code
- NCT07880847
- Record updated
- 19 October 2026
- Original description
Obesity is a multifactorial chronic disease whose prevalence is steadily increasing worldwide, with substantial clinical, functional, psychological, and economic consequences. Body mass index (BMI) and staging systems such as the Edmonton Obesity Staging System (EOSS) allow obesity severity and associated cardiometabolic risk to be assessed, but they do not fully capture the complexity of the condition.Read full original descriptionShow less
MORPH-A - Multidisciplinary Obesity Rehabilitation & Psychophysical Health and Awareness. A Multidisciplinary Outpatient Rehabilitation Programme for Obese Patients With Comorbidities
Obesity is a multifactorial chronic disease whose prevalence is steadily increasing worldwide, with substantial clinical, functional, psychological, and economic consequences. Body mass index (BMI) and staging systems such as the Edmonton Obesity Staging System (EOSS) allow obesity severity and associated cardiometabolic risk to be assessed, but they do not fully capture the complexity of the condition.
Although its etiology is not yet fully understood, obesity results from the interaction of multiple factors. Individual susceptibility, including a hereditary component, interacts with psychobehavioral factors such as dysfunctional eating patterns and sedentary behavior, endocrine disorders in some cases, and broader sociocultural and environmental determinants, including socioeconomic status and lifestyle. This etiological complexity is reflected in the wide-ranging impact of obesity on health: in addition to increasing the risk of numerous clinical complications, obesity can substantially affect psychosocial well-being and quality of life.
Given this multifactorial nature, current evidence and clinical guidelines support interventions that move beyond unidimensional approaches and address multiple dimensions of the condition in an integrated manner. The present study aims to evaluate the efficacy of an integrated multidisciplinary approach to obesity management compared with usual clinical care. The study hypothesis is that the combination of personalized nutritional, physiotherapeutic, and psychotherapeutic interventions can promote greater and more sustained weight loss, as well as better psycho-physiological outcomes.
Inclusion: Age >18 years; Class I or II obesity assessed at T0 with comorbid risk factors (EOSS > or equal to 2) for which an SIO appropriateness form with a score > or equal to 20 has been completed; Patients who agree to begin treatment with a GLP-1 or GLP-1/GIP analog; Fit for physical exercise; Willingness to participate in the 12-week program; Understanding of the Italian language and ability to complete the questionnaires; Understanding of the research objectives and ability to provide informed consent.
Exclusion: Functional limitations that prevent participation in physical therapy sessions; Concurrent participation in other trials that could potentially interfere with the outcomes of this study; Major psychiatric disorders, substance abuse; Obesity secondary to genetic and endocrinological disorders (e.g., hypercortisolism, acromegaly, overt hypothyroidism); Age < 18 years; Non-Italian education, illiteracy, or relapse into illiteracy; Low motivation/interest or refusal to undergo assessment; Absence of comorbidities (EOSS < or equal to 1).