MRI study of airway changes with nasal high flow and CPAP in COPD
Looks at how two breathing devices change the upper airway in COPD.
Plain-language title generated from the registry record
Registry title: Upper Airway Morphology and Physiology During Graded Positive Pressure and Nasal High Flow: An MRI Study
Key facts
- Where
- Dortmund, GermanySee the site
Where in Germany
- Klinikum DortmundDortmund, GermanyNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Klinikum Dortmund Wirbelsäulenchirurgie
- Trial code
- NCT07886502
- Record updated
- 21 October 2026
- Original description
This study investigates the effects of graded nasal high flow (NHF) and continuous positive airway pressure (CPAP) on upper airway morphology and respiratory physiology in healthy volunteers and patients with COPD. Participants undergo baseline MRI and physiological assessment followed by NHF at 30 and 60 L/min and CPAP at 4 and 12 cmH₂O. The primary aim is to determine whether graded NHF and CPAP induce dose-dependent changes in upper airway morphology, including upper airway volume and cross-sectional area, during MRI scans.Read full original descriptionShow less
Effects of Graded Positive Airway Pressure and Nasal High Flow Interfaces on Upper Airway Morphology and Breathing Physiology in Healthy Volunteers and COPD Patients: A Controlled MRI Study
This study investigates the effects of graded nasal high flow (NHF) and continuous positive airway pressure (CPAP) on upper airway morphology and respiratory physiology in healthy volunteers and patients with COPD. Participants undergo baseline MRI and physiological assessment followed by NHF at 30 and 60 L/min and CPAP at 4 and 12 cmH₂O. The primary aim is to determine whether graded NHF and CPAP induce dose-dependent changes in upper airway morphology, including upper airway volume and cross-sectional area, during MRI scans.
Inclusion: Written informed consent; Age ≥18 years; BMI ≤30 kg/m².
Exclusion: Contraindications to MRI (e.g., claustrophobia or ferromagnetic implants); Alcohol, drug, medication, or other substance abuse; Physical or mental conditions limiting study participation or compliance, as judged by the investigator; Inability or refusal to provide informed consent; Contraindications to mask-based positive airway pressure or nasal high flow; Pregnancy; Any other objective reason preventing study participation, as determined by the investigator.