Tests LY4086940 for weight management in adults with obesity or overweight
Tests LY4086940 against placebo in adults with obesity or overweight.
Plain-language title generated from the registry record
Registry title: A Study to Investigate the Effect of LY4086940 Versus Placebo in Participants With Obesity or Overweight and Without Type 2 Diabetes
Key facts
- Where
- Amherst, Ammon, Austin, Chandler, Chicago, Cincinnati, City of Saint Peters, Dallas, Danville, Greenbrae, Greenville, Huntington Park, Las Vegas, Miami, Miami Lakes, Monroe, Morehead City, Nashville, Needham, New Bedford, New Bern, New Port Richey, Orlando, Rochester, Rolling Hills Estates, San Antonio, Scottsdale, Southfield, Springfield, Stamford, The Villages, Topeka, Troy, Tucson, Walnut Creek, Wenatchee, Weslaco, and West Des Moines, United StatesSee the 39 sites
- Phase
- Phase 2
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Source: NCT07890376, who can take part
Where in United States
- Dent Neurologic InstituteAmherst, United StatesNo longer taking part
- Medical Research PartnersAmmon, United StatesNo longer taking part
- IMA Clinical Research AustinAustin, United StatesNo longer taking part
- The Institute for Liver Health II dba Arizona Clinical Trials - MesaChandler, United StatesNo longer taking part
- Great Lakes Clinical Trials - RavenswoodChicago, United StatesNo longer taking part
- CTI Clinical Research CenterCincinnati, United StatesNo longer taking part
- StudyMetrix ResearchCity of Saint Peters, United StatesNo longer taking part
- FutureSearch Trials of DallasDallas, United StatesNo longer taking part
- Velocity Clinical Research, DallasDallas, United StatesNo longer taking part
- Sovah Clinical Research-River DistrictDanville, United StatesNo longer taking part
- NorCal Medical Research, IncGreenbrae, United StatesNo longer taking part
- Tribe Clinical Research LLCGreenville, United StatesNo longer taking part
- Velocity Clinical Research-Huntington ParkHuntington Park, United StatesNo longer taking part
- Las Vegas Medical ResearchLas Vegas, United StatesNo longer taking part
- New Horizon Research CenterMiami, United StatesNo longer taking part
- Indago Research & Health Center, IncMiami Lakes, United StatesNo longer taking part
- Monroe Biomedical ResearchMonroe, United StatesNo longer taking part
- Lucas Research, Inc.Morehead City, United StatesNo longer taking part
- Quality Medical ResearchNashville, United StatesNo longer taking part
- KnownwellNeedham, United StatesNo longer taking part
- Lucida Clinical TrialsNew Bedford, United StatesNo longer taking part
- Lucas Research, Inc.New Bern, United StatesNo longer taking part
- Suncoast Clinical Research, Inc.New Port Richey, United StatesNo longer taking part
- Charter Research - Winter ParkOrlando, United StatesNo longer taking part
- Rochester Clinical Research, LLCRochester, United StatesNo longer taking part
- Peninsula Research AssociatesRolling Hills Estates, United StatesNo longer taking part
- Endeavor Clinical TrialsSan Antonio, United StatesNo longer taking part
- Headlands Research - ScottsdaleScottsdale, United StatesNo longer taking part
- Headlands Research - DetroitSouthfield, United StatesNo longer taking part
- Clinvest Headlands LLCSpringfield, United StatesNo longer taking part
- Stamford Therapeutics ConsortiumStamford, United StatesNo longer taking part
- Charter Research - Lady LakeThe Villages, United StatesNo longer taking part
- Cotton O'Neil Diabetes & EndocrinologyTopeka, United StatesNo longer taking part
- Arcturus Healthcare , PLC, Troy Internal Medicine Research DivisionTroy, United StatesNo longer taking part
- The Institute for Liver Health II dba Arizona Liver Health-TucsonTucson, United StatesNo longer taking part
- Diablo Clinical Research, Inc.Walnut Creek, United StatesNo longer taking part
- Central Washington Health Services Association d/b/a Confluence HealthWenatchee, United StatesNo longer taking part
- Texas Valley Clinical ResearchWeslaco, United StatesNo longer taking part
- Iowa Diabetes and Endocrinology Research CenterWest Des Moines, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Eli Lilly and Company
- Trial code
- NCT07890376
- Record updated
- 3 November 2026
- Original description
The purpose of this study, performed under the master protocol W8M-MC- CWMM (NCT06143956), is to evaluate the efficacy and safety of LY4086940 compared with placebo in participants without type 2 diabetes who have obesity or who have overweight with a weight-related health condition.Read full original descriptionShow less
A Phase 2, Parallel-Group, Double-Blind Study to Investigate Weight Management With LY4086940 Compared With Placebo in Adult Participants With Obesity or Overweight and Without Type 2 Diabetes
The purpose of this study, performed under the master protocol W8M-MC- CWMM (NCT06143956), is to evaluate the efficacy and safety of LY4086940 compared with placebo in participants without type 2 diabetes who have obesity or who have overweight with a weight-related health condition.
Participation in the study will last about 58 weeks.
Inclusion: Meet inclusion criteria under Master Protocol CWMM (NCT06143956).
Exclusion: Have any prior diagnosis of type 2 diabetes, type 1 diabetes, or rare forms of diabetes mellitus, except gestational diabetes; Have any of the following cardiovascular conditions within 6 months prior to screening:; acute myocardial infarction; cerebrovascular accident (stroke); unstable angina, or; hospitalization due to congestive heart failure; Within 6 months prior to screening, have taken medications (prescribed or over the counter) or alternative remedies (including herbal or nutritional supplements) that promote weight loss; Have a laboratory value suggestive of diabetes; In addition to exclusion criteria under Master Protocol CWMM (NCT06143956); Have a known personal or family history (first-degree relative) of multiple endocrine neoplasia type 2A or 2B, thyroid C-cell hyperplasia, or medullary thyroid carcinoma.