Brain Activity and Emotions During Real-Life Events in Depression and Anxiety
Studies how the brain responds to real-life academic feedback in adults with depression or anxiety.
Plain-language title generated from the registry record
Registry title: Neural Mechanisms of Real-world Emotions and Internalizing
Key facts
- Where
- Coral Gables, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 35 years old?
Source: NCT07891624, who can take part
Where in United States
- University of MiamiCoral Gables, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Miami
- Trial code
- NCT07891624
- Record updated
- 23 October 2026
- Original description
This study utilizes mobile health methods, including smartphone technology, subjective self-reports measures of emotion, behavioral tasks, functional Magnetic Resonance Imaging (fMRI), physiological measures of attention and arousal, and measures of health and social support to identify neural mechanisms associated with individual differences in the temporal course of emotional responses. The aim of this project is to utilize real-world and personally relevant events as stimuli to better understand how the temporal course of emotional responses relate to risk for developing mental disorders.Read full original descriptionShow less
Using High-stakes, Real-world Events to Map the Neural Dynamics Linked to Internalizing Disorders
This study utilizes mobile health methods, including smartphone technology, subjective self-reports measures of emotion, behavioral tasks, functional Magnetic Resonance Imaging (fMRI), physiological measures of attention and arousal, and measures of health and social support to identify neural mechanisms associated with individual differences in the temporal course of emotional responses. The aim of this project is to utilize real-world and personally relevant events as stimuli to better understand how the temporal course of emotional responses relate to risk for developing mental disorders.
Inclusion: Individuals who are between 18 - 35 years old. [Reason: to be able to provide informed consent, and to minimize variation in functional and structural differences in brain]; Individuals who are fluent English speakers. [Reason: to understand study instructions \& questionnaires]; Smart phone access. [Reason: to answer the questionnaires that are administered throughout the study.
Exclusion: Women who are pregnant or breast feeding and are no more than six months post-partum. [Reason: may be unsafe for fetus, may affect outcome measure(s)]; Individuals who are excluded based on attached metal resonance Screening Form (Note: this form has already been approved by the Institutional Review Board (IRB for other protocols). [Reason: necessary to participate in MRI research protocol]; Individuals whose BMI is above 35. [Reason: must fit into fMRI scanner]; Individuals who have claustrophobia. [Reason: to be able to stay in MRI scanner]; Individuals who are unable, in the judgment of the investigator, to comply with directions and/or tolerate the procedures required for participation in this trial. [Reason: to be able to understand instructions and ensure safety]; Individuals who are unable to safely undergo MRI scanning. [Reason: to be able to undergo MRI scanning].