Eloralintide Study for Weight, Diabetes and Heart Risk in Adults
Tests eloralintide against placebo in adults with obesity, diabetes and heart risk.
Plain-language title generated from the registry record
Registry title: A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, Type 2 Diabetes, and Increased Cardiovascular Risk
Key facts
- Where
- Altamonte Springs, Amarillo, Apache Junction, Arlington, Arlington Heights, Augusta, Baltimore, Birmingham, Brandon, Cincinnati, Corvallis, Covina, Cutler Bay, Dallas, East Providence, El Paso, Escondido, Exton, Fleming Island, Fort Worth, Franklin, Gilbert, Greenfield, Honolulu, Houston, Humble, Huntsville, Jacksonville, Lancaster, Las Vegas, Leesburg, Long Beach, Longview, McAllen, McKinney, Media, Miami, Morehead City, Nashua, New Bedford, Norfolk, Northridge, Ogden, Oxnard, Pasadena, Pembroke Pines, Phoenix, Port Charlotte, Redmond, Richmond, Ridgeland, Rochester, Saint Joseph, San Antonio, San Diego, Santa Clarita, Southfield, Springfield, Surprise, Tinley Park, Waterbury, Westlake Village, Wilmington, and Wylie, United StatesSee the 70 sites
- Phase
- Phase 3
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 45 and 64 years old?
Source: NCT07900633, who can take part
Where in United States
- Omega Research OrlandoAltamonte Springs, United StatesNo longer taking part
- Amarillo Medical SpecialistsAmarillo, United StatesNo longer taking part
- Smiths Medical CenterApache Junction, United StatesNo longer taking part
- Care Access - Arlington 2Arlington, United StatesNo longer taking part
- Virginia Nephrology GroupArlington, United StatesNo longer taking part
- Care Access - Arlington HeightsArlington Heights, United StatesNo longer taking part
- Southeastern Clinical Research InstituteAugusta, United StatesNo longer taking part
- Ascension Saint Agnes Heart CareBaltimore, United StatesNo longer taking part
- Care Access - BaltimoreBaltimore, United StatesNo longer taking part
- Central Research AssociatesBirmingham, United StatesNo longer taking part
- University of Alabama - Department of Nutrition SciencesBirmingham, United StatesNo longer taking part
- Care Access - BrandonBrandon, United StatesNo longer taking part
- Kidney and Hypertension CenterCincinnati, United StatesNo longer taking part
- The Corvallis Clinic, P.C.Corvallis, United StatesNo longer taking part
- Valley Clinical Trials, Inc.Covina, United StatesNo longer taking part
- American Research InstituteCutler Bay, United StatesNo longer taking part
- Renal Disease Research InstituteDallas, United StatesNo longer taking part
- Nephrology Associates - East ProvidenceEast Providence, United StatesNo longer taking part
- Headlands Research-El PasoEl Paso, United StatesNo longer taking part
- Neighborhood Healthcare Institute of HealthEscondido, United StatesNo longer taking part
- Clinical Renal Associates, LTDExton, United StatesNo longer taking part
- Fleming Island Center for Clinical ResearchFleming Island, United StatesNo longer taking part
- Valley Institute of Research - Fort WorthFort Worth, United StatesNo longer taking part
- American Health Network of Indiana, LLC - FranklinFranklin, United StatesNo longer taking part
- Prime Medical Group, LLC dba Gilbert Center for Family Medicine, LLCGilbert, United StatesNo longer taking part
- American Health Network of Indiana, LLC_GreenfieldGreenfield, United StatesNo longer taking part
- East-West Medical Research InstituteHonolulu, United StatesNo longer taking part
- Biopharma Informatic, LLCHouston, United StatesNo longer taking part
- Research Physicians Network, LLCHouston, United StatesNo longer taking part
- Quality First Family Health/SKYCRNGHumble, United StatesNo longer taking part
- Nephrology ConsultantsHuntsville, United StatesNo longer taking part
- Northeast Research Institute - Downtown OfficeJacksonville, United StatesNo longer taking part
- First Valley Medical GroupLancaster, United StatesNo longer taking part
- DaVita Clinical Research - Las VegasLas Vegas, United StatesNo longer taking part
- Excel Clinical Research, LLCLas Vegas, United StatesNo longer taking part
- Lakeview Institute of Clinical ResearchLeesburg, United StatesNo longer taking part
- Ark Clinical ResearchLong Beach, United StatesNo longer taking part
- DCOL Center for Clinical ResearchLongview, United StatesNo longer taking part
- Biopharma Informatic, LLCMcAllen, United StatesNo longer taking part
- Revival Research Institute, LLCMcKinney, United StatesNo longer taking part
- Clinical Renal Associates Ltd.Media, United StatesNo longer taking part
- Millennium Medical Research - MiamiMiami, United StatesNo longer taking part
- ONHEALTH Research CenterMiami, United StatesNo longer taking part
- West Clinical ResearchMorehead City, United StatesNo longer taking part
- Southern Nh Diabetes and EndocrinologyNashua, United StatesNo longer taking part
- Lucida Clinical TrialsNew Bedford, United StatesNo longer taking part
- York Clinical ResearchNorfolk, United StatesNo longer taking part
- Valley Clinical Trials, LLC dba Flourish ResearchNorthridge, United StatesNo longer taking part
- Advanced Research InstituteOgden, United StatesNo longer taking part
- Fomat Medical ResearchOxnard, United StatesNo longer taking part
- Renal Specialists of HoustonPasadena, United StatesNo longer taking part
- Center for Diabetes, Obesity and MetabolismPembroke Pines, United StatesNo longer taking part
- Elite Clinical Studies, LLCPhoenix, United StatesNo longer taking part
- Peace River Cardiovascular CenterPort Charlotte, United StatesNo longer taking part
- Eastside Research AssociatesRedmond, United StatesNo longer taking part
- Dominion Medical Associates, Inc.Richmond, United StatesNo longer taking part
- SKY Integrative Medical Center/SKYCRNGRidgeland, United StatesNo longer taking part
- Rochester Clinical Research, LLCRochester, United StatesNo longer taking part
- Lake Michigan NephrologySaint Joseph, United StatesNo longer taking part
- Clinical Advancement CenterSan Antonio, United StatesNo longer taking part
- Acclaim Clinical ResearchSan Diego, United StatesNo longer taking part
- Care Access - Santa ClaritaSanta Clarita, United StatesNo longer taking part
- Revive Research Institute, IncSouthfield, United StatesNo longer taking part
- Clinvest Headlands LLCSpringfield, United StatesNo longer taking part
- Southwest Kidney Institute - SurpriseSurprise, United StatesNo longer taking part
- Healthcare Research Network - ChicagoTinley Park, United StatesNo longer taking part
- Chase Medical Research, LLCWaterbury, United StatesNo longer taking part
- Millennium Clinical TrialsWestlake Village, United StatesNo longer taking part
- Trial Management Associates - Wilmington - Floral ParkwayWilmington, United StatesNo longer taking part
- Medrasa Clinical ResearchWylie, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Eli Lilly and Company
- Trial code
- NCT07900633EU 2026-525919-14-00
- Record updated
- 3 November 2026
- Original description
The main purpose of this study is to evaluate the efficacy and safety of eloralintide compared with a placebo in participants with obesity or overweight, type 2 diabetes, and increased cardiovascular risk.Read full original descriptionShow less
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Once-Weekly Eloralintide in Adult Participants With Obesity or Overweight, Type 2 Diabetes, and Increased CV Risk
The main purpose of this study is to evaluate the efficacy and safety of eloralintide compared with a placebo in participants with obesity or overweight, type 2 diabetes, and increased cardiovascular risk.
Inclusion: Have type 2 diabetes; Have a HbA1c value between ≥ 6.5% and ≤ 9.5% at screening; Are on stable treatment with an unchanged dose of at least 1 and no more than 4 antihyperglycemic therapies for at least 90 days before screening; Have an increased risk of cardiovascular events; Have a BMI ≥ 25.0 kg/m2 at screening; Have a stable body weight (<5% body weight change) for 90 days prior to screening; Have a history of at least one self-reported unsuccessful dietary effort to reduce body weight.
Exclusion: Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed >1 year before screening); Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening); Have had within 60 days prior to screening:; acute myocardial infarction; stroke; hospitalization for congestive heart failure, or; coronary, peripheral, or carotid artery revascularization procedure; Have received treatment combining sulfonylurea and insulin within 90 days prior to screening; Have type 1 diabetes; Have a history or diagnosis of New York Heart Association Functional Classification IV congestive heart failure.