Studying KLF4 gene methylation as colorectal polyps progress toward adenomas and cancer
Measures KLF4 methylation in colon tissue taken during routine colonoscopy in adults.
Plain-language title generated from the registry record
Registry title: KLF4 Epigenetic Modulation
Key facts
- Where
- Reggio Emilia, ItalySee the site
Where in Italy
- Azienda USL IRCCS di Reggio EmiliaReggio Emilia, ItalyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Azienda USL Reggio Emilia - IRCCS
- Trial code
- NCT07901335
- Record updated
- 10 November 2026
- Original description
The study investigates the epigenetic regulation of KLF4 during the progression from colorectal polyps to adenomas and carcinomas. Quantitative KLF4 methylation will be assessed in colorectal tissue samples obtained during routine colonoscopy, together with KLF4 gene expression and its correlation with methylation status in matched tissue samples. The study will also evaluate quantitative and site-specific molecular approaches for the assessment of KLF4 methylation.Read full original descriptionShow less
KLF4 Epigenetic Modulation During Polyps-adenoma Progression
The study investigates the epigenetic regulation of KLF4 during the progression from colorectal polyps to adenomas and carcinomas. Quantitative KLF4 methylation will be assessed in colorectal tissue samples obtained during routine colonoscopy, together with KLF4 gene expression and its correlation with methylation status in matched tissue samples. The study will also evaluate quantitative and site-specific molecular approaches for the assessment of KLF4 methylation.
Inclusion: Patients undergoing routine colonoscopy; > 18 years of age; Diagnosed by S.C. Anatomia Patologica, AUSL-IRCCS Reggio Emilia.
Exclusion: Concomitant diagnosis of colorectal carcinoma.