Colorectal cancer trials in Italy

In Italy 157 Also abroad 1930

157 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 11 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
KLF4 Epigenetic Modulation
Where
Reggio Emilia
Age
18 years and over
People
170
Run by
Azienda USL Reggio Emilia - IRCCS
See details and how to joinNCT07901335
Phase 1Taking people
START: Safety and Anti-Tumor Activity of PeptiCRAd-1 in Treatment of Cancer
Where
Candiolo, Milan, Naples, Rozzano
Age
18 years and over
People
15 worldwide
Run by
Valo Therapeutics Oy
See details and how to joinNCT05492682 · EU 2024-517580-23-00
Phase 1Taking people
A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)
Where
Meldola, Milan, Naples, Padova, Rome
Age
18 years and over
People
542 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT04929223 · EU 2023-505163-37-00
Phase 1/2Taking people
Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread
Where
Ancona, Candiolo (TO), Meldola (FC), Milan, Misterbianco (CT), Naples, Rozzano
Age
18 years and over
People
910 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT06324357
Phase 3Taking people
Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer
Where
Aviano, Brescia, Florence, Genova, Meldola, Milan, Pisa, Roma, Verona
Age
18 years and over
People
900 worldwide
Run by
Summit Therapeutics
See details and how to joinNCT07228832
Phase 3Taking people
A Study of Precemtabart Tocentecan With or Without Bevacizumab Compared to Trifluridine/Tipiracil Plus Bevacizumab in Participants With Previously Treated Metastatic Colorectal Cancer (PROCEADE-CRC-03)
Where
Castellana Grotte, Milan, Naples, Padova, Pisa, Reggio Emilia, Rome
Age
18 years and over
People
1,020 worldwide
Run by
EMD Serono Research & Development Institute, Inc.
See details and how to joinNCT07549412 · EU 2025-524648-37-00
Phase 1Taking people
A Study of Sofe-M in Participants With Selected Advanced Solid Tumors
Where
Milan
Age
18 years and over
People
575 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT06400472 · EU 2024-511238-11-00
Phase 2Taking people
A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)
Where
Milan, Reggio Emilia, Rome
Age
18 years and over
People
111 worldwide
Run by
Bayer
See details and how to joinNCT06760819 · EU 2024-517419-62-00
Phase 3Taking people
A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)
Where
Candiolo, Leghorn, Milan, Monserrato, Naples, Padova, Perugia, Ravenna, Rozzano, Verona
Age
18 years and over
People
477 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT06997497 · EU 2024-517232-22-00
Phase 1/2Taking people
A Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer
Where
Milan, Pisa
Age
18 years and over
People
225 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT05379595 · EU 2023-506517-22-00
Phase 3Taking people
A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer
Where
Faenza, Lugo, Milan, Padova, Pisa, Ravenna, Rozzano
Age
18 years and over
People
1,000 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT06662786 · EU 2024-513852-13-00
Phase 3Taking people
A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy
Where
Candiolo, Catania, Florence, Milan, Padova, Pisa, Rozzano
Age
18 years and over
People
700 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT06750094 · EU 2024-513853-66-00
Phase 1/2Taking people
A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors
Where
Milan
Age
18 years and over
People
560 worldwide
Run by
Genmab
See details and how to joinNCT03526835 · EU 2024-513627-16-01
No phaseTaking people
Artificial Intelligence to Implement Cost-saving Strategies for Colonoscopy Screening Based on in Vivo Prediction of Polyp Histology
Where
Rozzano
Age
40 years and over
People
1,800
Run by
Istituto Clinico Humanitas
See details and how to joinNCT06041945
Phase 1/2Taking people
EIK1005-002: A Clinical Research Study Evaluating EIK1005, a Werner Helicase Inhibitor, as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors Including Microsatellite Instability High (MSI-H) Tumors
Where
Rome
Age
18 years and over
People
160 worldwide
Run by
Eikon Therapeutics
See details and how to joinNCT07262619 · EU 2026-525248-13-00
Phase 3Taking people
A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer
Where
Ancona, Aviano, Bari, Brescia, Candiolo, Milan, Naples, Padova, Pisa, Ravenna, Reggio Emilia, Rome, Rozzano, San Giovanni Rotondo, Verona
Age
18 years and over
People
700 worldwide
Run by
Incyte Corporation
See details and how to joinNCT07284849 · EU 2025-523735-19-00
Phase 1/2Taking people
A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)
Where
Milan, Rome
Age
18 years and over
People
220 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT06428409 · EU 2023-508703-21-00
Phase 1/2Taking people
BOLD-100 in Combination With FOLFOX With or Without Bevacizumab for the Treatment of Advanced, Solid Tumours
Where
Milan, Naples, Pisa
Age
18 years and over
People
220 worldwide
Run by
Bold Therapeutics, Inc.
See details and how to joinNCT04421820 · EU 2024-517500-11-00
Phase 2Taking people
A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer
Where
Milan, Naples, Padova, Pisa, Rome, Rozzano, Turin
Age
18 years and over
People
390 worldwide
Run by
AbbVie
See details and how to joinNCT06820463 · EU 2024-512981-33-00
Phase 2Taking people
Neoadjuvant Pembrolizumab and Porustobart in Resectable pMMR/MSS Colon Cancer
Where
Milan, Naples, Pisa
Age
18 years and over
People
100 worldwide
Run by
Solstice Oncology, Inc.
See details and how to joinNCT07808151 · EU 2026-527233-58-00
Phase 3Not yet taking people in Italy
Study of Petosemtamab Plus Chemotherapy Versus Cetuximab Plus Chemotherapy in RAS and BRAF Wild-type, Unresectable or Metastatic, Left-sided Colorectal Cancer.
Where
Ancona, Avellino, Florence, Meldola, Milan, Naples, Pisa, Ravenna, Reggio Emilia, Rome, Rozzano, San Giovanni Rotondo, Tricase, Udine
Age
18 years and over
People
450 worldwide
Run by
Genmab A/S
See details and how to join2026-525883-17-00 · EU 2026-525883-17-00
Phase 1/2Taking people
A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)
Where
Candiolo, Milan, Naples, Rome, Rozzano
Age
18 years and over
People
680 worldwide
Run by
Daiichi Sankyo
See details and how to joinNCT06330064 · EU 2023-509632-26-00
Phase 2/3Taking people
A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer
Where
Avellino, Aviano, Bari, Castellana Grotte, Catania, La Spezia, Milan, Milano, Naples, Padova, Pisa, Ravenna, Reggio Emilia, San Giovanni Rotondo, Tricase
Age
18 years and over
People
990 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT07221357 · EU 2025-523224-45-00
Phase 2Taking people
A Study to Evaluate the Efficacy of VVD-133214 in Combination With Pembrolizumab Compared With Pembrolizumab Alone in Participants With Advanced Cancer of the Colon or Rectum
Where
Milan, Naples, Rome, Rozzano
Age
18 years and over
People
140 worldwide
Run by
Vividion Therapeutics, Inc.
See details and how to joinNCT07811193 · EU 2026-525507-26-00
Phase 3Taking people
Randomized phase 3 study of intermittent or continuous Panitumumab plus FOLFIRI for first-line treatment of patients with unresectable left sided RAS/B-RAF wild-type metastatic colorectal cancer (IMPROVE-2 trial)
Where
Ancona, Avellino, Bari, Bergamo, Brescia, Caserta, Castellana Grotte, Catania, Catanzaro, Firenze, Foggia, Frattamaggiore, Genoa, Lecce, Legnano, Località la Schiana, Pozzuoli (NA), Milan, Milano, Mirabella Eclano, Naples, Padova, Palermo, Pavia, Pescara, Peschiera del Garda, Pisa, Potenza, Ragusa, Reggio Emilia, Roma, Rome, San Giovanni Rotondo, Sassari, Statte, Teramo, Torino, Tricase, Verona, A.O.U Maggiore della Carità
Age
18 years and over
People
500
Run by
IRCCS Istituto Nazionale Tumori Fondazione Pascale
See details and how to join2023-509551-14-00 · EU 2023-509551-14-00