Comparing exercise types for lowering blood pressure in young adults with hypertension
Compares aerobic, resistance and isometric exercise for blood pressure in young adults with hypertension.
Plain-language title generated from the registry record
Registry title: A MOST Framework Trial Evaluating the MOst effectiVe Exercise Types for Blood Pressure Control
Key facts
- Where
- Chicago, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 44 years old?
Source: NCT07915752, who can take part
Where in United States
- Northwestern UniversityChicago, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Northwestern University
- Trial code
- NCT07915752
- Record updated
- 6 November 2026
- Original description
Exercise is known to prevent nearly one in three cases of hypertension and slow its progression in young adults, but we do not know which specific exercise types are most effective. The main objective of this study is to determine which exercise prescription (ExRx) intervention component(s) alone or in combination most effectively lower systolic BP in young adults with stage I hypertension, identify the vascular mechanisms underlying these changes, and guide the development of optimized exercise-based prescription packages for effective hypertension control in this population.Read full original descriptionShow less
A MOST Framework Trial Evaluating the MOst effectiVe Exercise Types for Blood Pressure Control
Exercise is known to prevent nearly one in three cases of hypertension and slow its progression in young adults, but we do not know which specific exercise types are most effective. The main objective of this study is to determine which exercise prescription (ExRx) intervention component(s) alone or in combination most effectively lower systolic BP in young adults with stage I hypertension, identify the vascular mechanisms underlying these changes, and guide the development of optimized exercise-based prescription packages for effective hypertension control in this population.
Inclusion: Age 18 to 44 years; Northwestern University patient with untreated Stage I hypertension (blood pressure 130-139/80-89 mmHg) documented on at least 2 outpatient encounters in the prior year; No current antihypertensive medication use; Estimated 10-year cardiovascular disease risk below 7.5% by the PREVENT risk calculator; Body mass index 18.5 to 39.9 kg/m2; Average home blood pressure of 130-139/80-89 mmHg during a 7-day home monitoring period; Fewer than 150 minutes per week of moderate-to-vigorous physical activity measured by accelerometer; Exercise readiness confirmed by the Physical Activity Readiness Questionnaire for Everyone (PAR-Q+), with medical clearance if indicated; English fluency; Reliable internet access on a computer, smartphone, or tablet, with videoconference capability (e.g., Zoom).
Exclusion: Weight change of more than 15 lbs in the prior 3 months; Active cancer and/or currently receiving cancer treatment; History of type 1 or type 2 diabetes; History of chronic kidney disease; History of chronic obstructive pulmonary disease; History of cardiovascular disease or coronary heart disease; Absolute contraindication to exercise (e.g., severe neurological, psychological, or orthopedic condition); Use of a glucagon-like peptide-1 receptor agonist (GLP-1 RA) within the past year; Pregnant or planning to become pregnant within 6 months.