Home Breathing Muscle Training for People With Pulmonary Hypertension
Tests breathing muscle training at home against a sham program in adults with pulmonary hypertension.
Plain-language title generated from the registry record
Registry title: Home-based Inspiratory Muscle Training in Pulmonary Hypertension
Key facts
- Where
- Madrid, SpainSee the site
Where in Spain
- Universidad Complutense de MadridMadrid, SpainNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Universidad Complutense de Madrid
- Trial code
- NCT07917416
- Record updated
- 4 November 2026
- Original description
The main objective of this study is to determine whether an 8-week inspiratory muscle training (IMT) programme, delivered at home through telerehabilitation, improves ventilatory efficiency (VE/VCO2 slope) compared with a sham (placebo) training programme in adults with pulmonary hypertension. Secondary objectives are to analyse its effects on airway inflammation, inspiratory muscle strength, lung function, ventilatory pattern and mechanical efficiency during exercise, dyspnoea and health-related quality of life.Read full original descriptionShow less
Efficacy of Inspiratory Muscle Training Delivered Through Telerehabilitation on Ventilatory Efficiency in People With Pulmonary Hypertension: a Double-blind, Placebo-controlled Randomized Clinical Trial
The main objective of this study is to determine whether an 8-week inspiratory muscle training (IMT) programme, delivered at home through telerehabilitation, improves ventilatory efficiency (VE/VCO2 slope) compared with a sham (placebo) training programme in adults with pulmonary hypertension. Secondary objectives are to analyse its effects on airway inflammation, inspiratory muscle strength, lung function, ventilatory pattern and mechanical efficiency during exercise, dyspnoea and health-related quality of life.
Forty participants will be randomly allocated (1:1) to active IMT or sham IMT. Both groups will train twice a day, 5 days a week, for 8 weeks, with biweekly load adjustments and supervision through video calls. Participants, therapists, outcome assessors and the statistician will be blinded to group allocation.
Inclusion: Age 18 years or older; Medical diagnosis of pulmonary hypertension group 1 (pulmonary arterial hypertension) or group 4 (chronic thromboembolic pulmonary hypertension) according to the 2022 ESC/ERS guidelines; Transthoracic echocardiography performed within the previous 6 months; Clinical stability: no hospitalizations, changes in PH-specific treatment or worsening of functional class in the previous 3 months; Sufficient functional capacity to perform cardiopulmonary exercise testing and the other study assessments; Signed informed consent.
Exclusion: Thoracic or abdominal surgery in the previous 3 months; Current participation in cardiopulmonary rehabilitation, or participation in the previous 3 months; Neuromuscular disease or conditions with primary diaphragmatic involvement; Severe comorbidities unrelated to PH pathophysiology (e.g., severe COPD or unstable ischaemic heart disease); Absolute contraindications to cardiopulmonary exercise testing according to current guidelines; Pregnancy or breastfeeding; Inability to understand or follow the telerehabilitation programme.