Comparing Two Types of Strength Training in Older Adults With Alzheimer's Disease
Compares two strength training styles with usual care in older adults with Alzheimer's disease.
Plain-language title generated from the registry record
Registry title: Exercise in Alzheimer's Disease: Functional Biomarkers
Key facts
- Where
- Valladolid, SpainSee the site
Where in Spain
- Miguel de Cervantes European UniversityValladolid, SpainNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- European University Miguel de Cervantes
- Trial code
- NCT07918417
- Record updated
- 5 November 2026
- Original description
Alzheimer's disease (AD) is the leading cause of dementia worldwide and involves systemic alterations beyond the brain, such as loss of muscle strength, chronic low-grade inflammation, and gut microbiome dysbiosis. Physical exercise is a promising non-pharmacological therapy, and velocity-based resistance training has proven safe and effective in older adults. However, the effects of performing resistance exercises at high versus moderate velocity in people with AD remain unknown, and human evidence on how exercise modulates the gut microbiome in AD is very limited. This study aims to assess and compare the effects of two velocity-based resistance training modalities (high load at moderate velocity and moderate load at high velocity) versus usual care on the gut microbiome, systemic inflammation, plasma biomarkers, biological age, and intrinsic capacity in older adults with mild-to-moderate AD, using cognitively healthy older adults as a reference group.Read full original descriptionShow less
Physical Exercise in Alzheimer's Disease: Impact on Functional Biomarkers and the Muscle-Gut-Brain Axis
Alzheimer's disease (AD) is the leading cause of dementia worldwide and involves systemic alterations beyond the brain, such as loss of muscle strength, chronic low-grade inflammation, and gut microbiome dysbiosis. Physical exercise is a promising non-pharmacological therapy, and velocity-based resistance training has proven safe and effective in older adults. However, the effects of performing resistance exercises at high versus moderate velocity in people with AD remain unknown, and human evidence on how exercise modulates the gut microbiome in AD is very limited. This study aims to assess and compare the effects of two velocity-based resistance training modalities (high load at moderate velocity and moderate load at high velocity) versus usual care on the gut microbiome, systemic inflammation, plasma biomarkers, biological age, and intrinsic capacity in older adults with mild-to-moderate AD, using cognitively healthy older adults as a reference group.
Inclusion: Age ≥ 60 years; Medical diagnosis of mild or moderate Alzheimer's disease based on clinical criteria and plasma biomarkers; Able to perform physical activity according to medical assessment; Written informed consent from the participant or, when capacity is insufficient, from the legal representative; Age ≥ 60 years; No medical diagnosis of Alzheimer's disease or cognitive impairment according to clinical criteria; Preserved functional autonomy; Able to perform physical activity according to medical assessment; Written informed consent.
Exclusion: Major surgery in the previous 3 months; Antibiotic, probiotic or corticosteroid treatment in the 4 weeks before biological sample collection; Uncontrolled neuromuscular disease or severe heart disease; Total functional dependence.