One or two courses of low-dose radiation for knee osteoarthritis
Compares one versus two courses of low-dose radiation in people with knee osteoarthritis.
Key facts
- Who runs it
- University of Wisconsin, Madison
- Where
- Madison, United StatesSee the site
- Trial code
- Registry title
- LDRT Retreatment for Knee Osteoarthritis
- Status
- Not yet recruiting
- Phase
- Phase 2
- People taking part
- 112 people, planned
- Starts
- Jan 2027
- Expected to end
- Jan 2033
- Type of study
- Interventional, 2 groups
- Treatments tested
- Low Dose Radiation Therapy
- Record updated
- 12 November 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults aged 40 or older with knee osteoarthritis pain. It compares one course with two courses of low-dose radiation therapy.
- Age
- 40 years or older
- Sex
- All sexes
- Disease stage
- Osteoarthritis of the knee diagnosed by a doctor, with joint pain lasting 3 months or more. Imaging of the joint (MRI, CT, X-ray or bone scan) done in the past 3 months.
- Earlier treatment
- No previous surgery or radiation to the affected joint. Radiation to other body areas is allowed if it does not overlap in a meaningful way, as the treating doctor decides.
- Biomarker or test result
- Negative pregnancy test
Main reasons for not taking part
- Previous surgery to the affected joint, or surgery planned in the next 6 months
- Previous radiation aimed at the affected joint
- Current use of prescription medicines that contain opioids
- Rheumatoid arthritis, pseudogout or gout in the affected joint
The registry criteria, word for word
Show all 9 criteriaShow less
Who can take part
- Clinical diagnosis of osteoarthritis of the knee
- Age ≥40 years at the time of consent
- Joint pain which has persisted for ≥3 months
- Completed imaging of the involved joint in the past 3 months (including MRI, CT, X-ray, or bone scan)
- Negative pregnancy test
Who cannot take part
- Previous surgery to the affected joint or planned surgery to the affected joint in the next 6 months
- Previous radiation treatment targeting the affected joint. Previous radiation targeting any other body site does not exclude from participation as long as there is no clinically meaningful overlap, as determined at the discretion of the treating physician
- Current use of prescription medications containing opioids
- Confirmed prior diagnosis of rheumatoid arthritis, pseudogout, or gout in the affected joint
Where in United States
- University of Wisconsin - MadisonMadison, United StatesContact: Marissa WeissNot yet recruiting
About the trial
What the trial wants to find out
The goal of this clinical trial is to learn if one course of low-dose radiation therapy (LDRT) helps as much as two courses of LDRT in people with osteoarthritis.
Read full original descriptionShow less
The main questions it aims to answer are whether pain control, joint function, and quality of life are the same with one course of LDRT.
Participants will receive LDRT and can expect to be in the study for up to 3 months.
The 2 groups in the trial
- One course of LDRTTreatment being tested
Participants will receive one course of LDRT
Treatment: Low Dose Radiation Therapy
- Two courses of LDRTTreatment being tested
Participants will receive two courses of LDRT
Treatment: Low Dose Radiation Therapy
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- UW26092: Low-Dose Radiation Therapy for Osteoarthritis of the Knee: A Phase 2 Randomized Trial of Dual-Course Versus Single-Course Radiation
- Plain-language title
- One or two courses of low-dose radiation for knee osteoarthritisGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 14 November 2026.
- Record updated
- 12 November 2026