Acute lymphoblastic leukaemia trials in United Kingdom

In United Kingdom 21 Also abroad 564

21 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 4Taking people
Asciminib Roll-over Study
Where
London, Oxford
Age
7 years to 100 years
People
347 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT04877522 · EU 2023-507557-16-00
Phase 1/2Taking people
Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)
Where
Birmingham, Cardiff, London, Newcastle upon Tyne, Sutton
Age
6 months to 25 years
People
90 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT06395103 · EU 2023-507178-41-00
Phase 1/2Taking people
Study of AZD3632 Monotherapy or in Combination With Anticancer Agents in Participants With Advanced Haematologic Malignancies With KMT2Ar, NPM1m, or Other Genotypes Associated With HOX Overexpression
Where
Edinburgh, London, Manchester, Newcastle
Age
16 years and over
People
85 worldwide
Run by
AstraZeneca
See details and how to joinNCT07155226 · EU 2025-521299-76-00
Phase 1/2Taking people
Study of AZD4512 Monotherapy or in Combination With Anticancer Agents in Participants With Acute Lymphoblastic Leukemia
Where
Bloomsbury, Manchester
Age
12 years and over
People
83 worldwide
Run by
AstraZeneca
See details and how to joinNCT07109219 · EU 2025-522372-93-00
Phase 3Taking people
Single-arm Study of IgPro20 in Adults With Secondary Immune Deficiencies Due to Hematologic Malignancies Treated With B-cell Targeting Chimeric Antigen Receptor T-cell and T-cell Redirecting Therapies
Where
Leicester, London
Age
18 years and over
People
63 worldwide
Run by
CSL Behring
See details and how to joinNCT07648264 · EU 2026-525626-38-00
Phase 1/2Taking people
AZD0486 as Monotherapy in B-cell Acute Lymphoblastic Leukaemia
Where
London, Manchester, Surrey
Age
12 years and over
People
255 worldwide
Run by
AstraZeneca
See details and how to joinNCT06137118 · EU 2023-505840-20-00
Phase 1/2Taking people
Safety and Efficacy of Ponatinib for Treatment of Pediatric Recurrent or Refractory Leukemias, Lymphomas or Solid Tumors
Where
Glasgow, Liverpool, Sutton
Age
1 year to 17 years
People
70 worldwide
Run by
Incyte Biosciences International Sàrl
See details and how to joinNCT03934372 · EU 2023-509699-41-00
Phase 1Taking people
A Study of CD19 Targeted CAR T Cell Therapy in Pediatric Patients With Relapsed or Refractory B Cell Acute Lymphoblastic Leukemia (B ALL) and Aggressive Mature B-cell Non-Hodgkin Lymphoma (B NHL)
Where
London, Manchester, Newcastle upon Tyne
Age
0 years to 18 years
People
30 worldwide
Run by
Autolus Limited
See details and how to joinNCT06173518 · EU 2023-506307-26-00
Phase 3Taking people
A Treatment Study Protocol for Participants 0-45 Years With Acute Lymphoblastic Leukaemia
Where
Aberdeen, Belfast, Birmingham, Bristol, Cambridge, Cardiff, Edinburgh, Glasgow, Leeds, Leicester, Liverpool, London, Manchester, Newcastle, Newcastle upon Tyne, Nottingham, Oxford, Plymouth, Sheffield, Southampton, Stoke, Sutton
Age
0 years to 45 years
People
6,430 worldwide
Run by
Mats Heyman
See details and how to joinNCT04307576 · EU 2022-501050-11-01
No phaseTaking people
Determining the Mechanisms of Loss of CAR T Cell Persistence
Where
London, Manchester
Age
Up to 25 years
People
50
Run by
University College, London
See details and how to joinNCT05809284
Phase 1Taking people
CARPALL: Immunotherapy With CD19+CD22 CAR T-cells for CD19+ and CD22+ Acute Lymphoblastic Leukaemia
Where
London, Manchester
Age
Up to 24 years
People
50
Run by
University College, London
See details and how to joinNCT02443831
Phase 2Taking people
Methods of T Cell Depletion Trial (MoTD)
Where
Birmingham, Bristol, Cambridge, Cardiff, Glasgow, Leeds, London, Manchester, Newcastle upon Tyne, Nottingham, Oxford, Plymouth, Sheffield, Sutton
Age
16 years to 70 years
People
400
Run by
University of Birmingham
See details and how to joinNCT04888741
Phase 3Taking people
A Study of Olverembatinib in Patients With Newly Diagnosed Ph+ ALL (POLARIS-1)
Where
Birmingham, Glasgow, London
Age
18 years and over
People
350 worldwide
Run by
Ascentage Pharma Group Inc.
See details and how to joinNCT06051409 · EU 2024-511496-14-00
Phase 1/2Taking people
A Phase 1/2 Study of Enzomenib (DSP-5336) in Patients With Acute Leukemia (Horizen-1)
Where
Birmingham, Bristol, Edinburgh, London, Manchester, Oxford, Stoke-on-Trent, Sutton
Age
12 years and over
People
606 worldwide
Run by
Sumitomo Pharma America, Inc.
See details and how to joinNCT04988555
Phase 2Taking people
International Study for Treatment of High Risk Childhood Relapsed ALL 2010
Where
Manchester
Age
Up to 17 years
People
250 worldwide
Run by
Charite University, Berlin, Germany
See details and how to joinNCT03590171 · EU 2024-513070-21-00
Phase 1Taking people
Anti-CCR9 CAR T Cells for T Cell Leukaemia/Lymphoma
Where
London
People
24
Run by
University College, London
See details and how to joinNCT07300683
Phase 1/2Taking people
HEM iSMART-D: Trametinib + Dexamethasone + Chemotherapy in Children With Relapsed or Refractory Hematological Malignancies
Where
Bristol, London, Manchester, Newcastle, Sutton
Age
1 year to 21 years
People
26 worldwide
Run by
Princess Maxima Center for Pediatric Oncology
See details and how to joinNCT05658640 · EU 2022-501869-41-00
Phase 1/2Taking people
HEM-iSMART-C: Ruxolitinib + Venetoclax + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies
Where
Bristol, London, Newcastle, Sutton
Age
1 year to 21 years
People
26 worldwide
Run by
Princess Maxima Center for Pediatric Oncology
See details and how to joinNCT05745714 · EU 2022-501867-42-01
Phase 1/2Taking people
HEM-iSMART-B: Dasatinib + Venetoclax + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies
Where
Bristol, London, Newcastle, Sutton
Age
1 year to 21 years
People
26 worldwide
Run by
Princess Maxima Center for Pediatric Oncology
See details and how to joinNCT05751044 · EU 2022-501866-22-00
Phase 2Taking people
Intestinal Microbiota Transplant Prior to Allogeneic Stem Cell Transplant (MAST) Trial
Where
Birmingham, Leeds, London, Manchester
Age
18 years and over
People
50
Run by
Imperial College London
See details and how to joinNCT06355583
No phaseNot yet taking people in United Kingdom
Obesity Prevention in Children and Young People Treated for Acute Lymphoblastic Leukaemia with ALLTogether
Where
Bristol
Age
5 years to 21 years
People
90 worldwide
Run by
University of Exeter
See details and how to joinNCT06846294