Acute lymphoblastic leukaemia trials in United States

In United States 232 Also abroad 564

232 trials · From ClinicalTrials.gov, checked 12 November 2026. Ask the study team whether a trial fits you.

Phase 3Taking people
Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy
Where
Akron, Albany, Albuquerque, Allentown, Amarillo, Anchorage, Ann Arbor, Asheville, Atlanta, Augusta, Aurora, Austin, Baltimore, Bangor, Bethesda, Birmingham, Boise, Boston, Brooklyn, Buffalo, Burlington, Chapel Hill, Charleston, Charlotte, Charlottesville, Chattanooga, Chicago, Cincinnati, Cleveland, Columbia, Columbus, Corpus Christi, Dallas, Danville, Dayton, Denver, Des Moines, Detroit, Downey, Duarte, Durham, East Lansing, El Paso, Falls Church, Fargo, Fort Lauderdale, Fort Myers, Fort Worth, Gainesville, Grand Rapids, Green Bay, Greenville, Hackensack, Hartford, Hershey, Hollywood, Honolulu, Houston, Huntington, Indianapolis, Iowa City, Jackson, Jacksonville, Kalamazoo, Kansas City, Knoxville, Las Vegas, Lebanon, Lexington, Little Rock, Loma Linda, Long Beach, Los Angeles, Louisville, Loxahatchee Groves, Lubbock, Macon, Madera, Madison, Marshfield, Maywood, McAllen, Mesa, Miami, Milwaukee, Mineola, Minneapolis, Mobile, Morgantown, Morristown, Nashville, Neptune City, Newark, New Brunswick, New Haven, New Hyde Park, New Orleans, New York, Norfolk, Oakland, Oak Lawn, Oklahoma City, Omaha, Orange, Orlando, Palo Alto, Park Ridge, Paterson, Pensacola, Peoria, Philadelphia, Phoenix, Pittsburgh, Portland, Portsmouth, Providence, Reno, Richmond, Roanoke, Rochester, Royal Oak, Sacramento, Salt Lake City, San Antonio, San Diego, San Francisco, Santa Barbara, Savannah, Scarborough, Seattle, Sioux Falls, Spokane, Springfield, St Louis, Stony Brook, St. Petersburg, Syracuse, Tacoma, Tampa, Temple, The Bronx, Toledo, Torrance, Tucson, Tulsa, Valhalla, Washington D.C., West Palm Beach, Wichita, Wilmington, Winfield, Winston-Salem, Worcester
Age
365 days to 25 years
People
5,951 worldwide
Run by
Children's Oncology Group
See details and how to joinNCT03959085
Phase 1/2Taking people
The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study
Where
Akron, Albany, Albuquerque, Allentown, Anchorage, Ann Arbor, Asheville, Atlanta, Aurora, Austin, Baltimore, Bangor, Bethesda, Birmingham, Boise, Boston, Brooklyn, Chapel Hill, Charleston, Charlotte, Charlottesville, Chicago, Cincinnati, Cleveland, Columbia, Columbus, Corpus Christi, Dallas, Danville, Dayton, Denver, Des Moines, Detroit, Downey, Durham, East Lansing, El Paso, Falls Church, Fargo, Fort Lauderdale, Fort Myers, Fort Worth, Gainesville, Grand Rapids, Greenville, Hackensack, Hartford, Hershey, Hollywood, Honolulu, Houston, Indianapolis, Iowa City, Jackson, Jacksonville, Kalamazoo, Kansas City, Knoxville, Las Vegas, Lebanon, Lexington, Little Rock, Loma Linda, Long Beach, Los Angeles, Louisville, Lubbock, Madera, Madison, Marshfield, Maywood, Memphis, Mesa, Miami, Mineola, Minneapolis, Mobile, Morgantown, Morristown, Nashville, Neptune City, New Brunswick, New Haven, New Hyde Park, New Orleans, New York, Norfolk, Oakland, Oak Lawn, Oklahoma City, Omaha, Orange, Orlando, Palo Alto, Park Ridge, Paterson, Pensacola, Peoria, Philadelphia, Phoenix, Pittsburgh, Portland, Providence, Reno, Richmond, Roanoke, Rochester, Royal Oak, Salt Lake City, San Antonio, San Diego, San Francisco, Savannah, Scarborough, Seattle, Sioux Falls, Spokane, Springfield, St Louis, Stony Brook, St. Petersburg, Syracuse, Tacoma, Tampa, The Bronx, Toledo, Tucson, Valhalla, Washington D.C., West Palm Beach, Wilmington, Winfield, Winston-Salem
Age
Up to 22 years
People
960 worldwide
Run by
PedAL BCU, LLC
See details and how to joinNCT04726241
No phaseTaking people
A Study to Learn More About the Health of Persons With Down Syndrome After Treatment for Acute Leukemia
Where
Akron, Albany, Ann Arbor, Atlanta, Augusta, Austin, Baltimore, Birmingham, Buffalo, Chapel Hill, Chicago, Cleveland, Columbia, Columbus, Dallas, Dayton, Detroit, Fargo, Fort Myers, Fort Worth, Grand Rapids, Greenville, Hackensack, Hollywood, Honolulu, Houston, Jackson, Jacksonville, Kalamazoo, Kansas City, Knoxville, Las Vegas, Madera, Madison, Marshfield, Memphis, Milwaukee, Minneapolis, Nashville, New Haven, Oakland, Oklahoma City, Omaha, Orlando, Pensacola, Philadelphia, Phoenix, Pittsburgh, Portland, Providence, Reno, Sacramento, San Antonio, San Diego, San Francisco, Seattle, Sioux Falls, Spokane, St Louis, Tampa, The Bronx, Wilmington, Winston-Salem
Age
6 years to 39 years
People
330 worldwide
Run by
Children's Oncology Group
See details and how to joinNCT05702645
Phase 1Taking people
Study of QUAIL-100 in Pediatric and Young Adult Participants With High-Risk Hematologic Malignancies Who Have Received a Hematopoietic Stem Cell Transplantation
Where
Palo Alto
Age
18 months to 39 years
People
12
Run by
Laguna Biotherapeutics, Inc.
See details and how to joinNCT07573111
Phase 2Taking people
A Study of Obecabtagene Autoleucel in People With B-cell Acute Lymphoblastic Leukemia
Where
Basking Ridge, Commack, Duarte, Harrison, Middletown, Montvale, New York, Stanford, Uniondale
Age
40 years and over
People
40
Run by
Memorial Sloan Kettering Cancer Center
See details and how to joinNCT07400029
Phase 2Taking people
Caloric Restriction and Activity to Reduce Chemoresistance in B-ALL
Where
Ann Arbor, Atlanta, Charlotte, Chicago, Cincinnati, Dallas, Denver, Houston, Kansas City, Los Angeles, Minneapolis, Orange, Philadelphia, Portland, Salt Lake City, San Francisco
Age
7 years to 25 years
People
240
Run by
Etan Orgel
See details and how to joinNCT05082519
No phaseTaking people
Evaluating the Effects of Hemoglobin Threshold-specific Packed Red Blood Cell Transfusions on Quality of Life and Functional Outcomes in Patients With High-grade Myeloid Neoplasms, Acute Myeloid Leukemia, or B Acute Lymphoblastic Lymphoma/Leukemia
Where
Seattle
Age
18 years and over
People
50
Run by
University of Washington
See details and how to joinNCT06710418
Phase 1/2Taking people
A Study of CTD402 in T-ALL/LBL Patients
Where
Chicago, Denver, Houston, Nashville, New York, Palo Alto, Rochester, The Bronx
Age
1 year and over
People
118 worldwide
Run by
Imviva Bio
See details and how to joinNCT07070219
Phase 1Taking people
Thiotepa-based Conditioning Regimen With De-escalated Post-graft Cyclophosphamide for Allogeneic Stem Cell Transplantation in Hematologic Malignancies
Where
Pittsburgh
Age
18 years and over
People
48
Run by
Sawa Ito, MD
See details and how to joinNCT07565220
Phase 2Taking people
ALL Backbone in AYAs
Where
Boston
Age
18 years to 51 years
People
67
Run by
Dana-Farber Cancer Institute
See details and how to joinNCT07227584
No phaseTaking people
Safety Study to Evaluate the Occurrence of EFAD in Pediatric Patients With PNAC Who Require More Than Eight Weeks of Omegaven Treatment
Where
Boston, Chicago, Cincinnati, Fountain Valley, Houston, Los Angeles, Nashville, Oklahoma City, San Antonio, Seattle
Age
1 day to 17 years
People
40
Run by
Fresenius Kabi
See details and how to joinNCT06274788
No phaseTaking people
Transcutaneous Auricular Vagus Nerve Stimulation for Insomnia in Survivors of Childhood Acute Lymphoblastic Leukemia
Where
Memphis
Age
20 years to 50 years
People
40
Run by
St. Jude Children's Research Hospital
See details and how to joinNCT07191119
No phaseTaking people
Evaluation of Pediatric eCART Implementation
Where
Madison
Age
Up to 17 years
People
30,000
Run by
University of Wisconsin, Madison
See details and how to joinNCT06771830
Phase 2Taking people
Dose-Adjusted EPOCH With or Without Rituximab Plus Ponatinib for the Treatment of Newly-Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia/Lymphoma
Where
Seattle
Age
18 years and over
People
33
Run by
University of Washington
See details and how to joinNCT07224100
No phaseTaking people
eHealth Mindfulness-based Music Therapy Intervention for Patients Undergoing Stem Cell Transplantation
Where
Miami
Age
18 years and over
People
165
Run by
University of Miami
See details and how to joinNCT07469592
No phaseTaking people
MedSupport Intervention to Identify and Address Barriers to Pediatric Medication Adherence
Where
Buffalo
People
150
Run by
Roswell Park Cancer Institute
See details and how to joinNCT06323044
Phase 2Taking people
Phase 2 Study Assessing the Clinical Activity and Safety of Obecabtagene Autoleucel as a Consolidation in Patients With Newly Diagnosed High-risk B-cell Acute Lymphocytic Leukemia (ALL)
Where
Houston
Age
18 years and over
People
30
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT07053059
Phase 1Not yet taking people in United States
A Phase IB Trial of Subcutaneous Blinatumomab in Combination With Revumenib for Patients With KMT2A-rearranged Acute Lymphoblastic Leukemia
Where
Houston
Age
18 years and over
People
20
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT07283640
Phase 1Taking people
Venetoclax, Dexamethasone, Bortezomib, and Daratumumab For The Treatment Of Adolescent And Young Adults With Relapsed Or Refractory T-Cell Acute Lymphoblastic Leukemia And T-cell Acute Lymphoblastic Lymphoma
Where
Houston
Age
12 years to 30 years
People
18
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT07513129
No phaseEnrolling by invitation
Little NIRVANA for Pediatric Pain and Anxiety
Where
Columbus
Age
2 years to 8 years
People
130
Run by
Nationwide Children's Hospital
See details and how to joinNCT06795126
Phase 1Not yet taking people in United States
Genetically Engineered Cells (BAFFR-CAR T Cells) for the Treatment of Relapsed or Refractory B-cell Acute Lymphoblastic Leukemia and B-cell Lymphoblastic Lymphoma
Where
Duarte, Irvine
Age
18 years and over
People
16
Run by
City of Hope Medical Center
See details and how to joinNCT07758673
Phase 2Taking people
Combination Chemotherapy in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia, Lymphoblastic Lymphoma, Burkitt Lymphoma/Leukemia, or Double-Hit Lymphoma/Leukemia
Where
Houston
Age
15 years and over
People
42
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT03136146
Phase 1Taking people
Feasibility and Safety of Collecting and Combining Autologous Hematopoietic Stem Cells With Chimeric Antigen Receptor (CAR) T-Cell Therapy in Subjects With Relapsed/Refractory Hematological Malignancies
Where
Los Angeles
Age
18 years to 85 years
People
20
Run by
Joshua Sasine, MD, PhD
See details and how to joinNCT05887167
Phase 1/2Taking people
Phase Ib/II Study Assessing the Clinical Activity and Safety of Brexucabtagene Autoleucel as a Consolidation in Patients With Relapsed/Refractory (R/R) and Newly Diagnosed B-cell Acute Lymphocytic Leukemia (ALL) Post Cytoreduction With Mini-HCVD-inotuzumab-blinatumomab/HCVAD-inotuzumab-blinatumomab
Where
Houston
Age
18 years and over
People
40
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT06287229
Phase 2Taking people
Adding Dasatinib Or Venetoclax To Improve Responses In Children With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (ALL) Or Lymphoma (T-LLY) Or Mixed Phenotype Acute Leukemia (MPAL)
Where
Charlotte, Memphis, San Diego, Tulsa
Age
1 year to 18 years
People
100
Run by
St. Jude Children's Research Hospital
See details and how to joinNCT06390319