ALS (motor neurone disease) trials in Canada

In Canada 16 Also abroad 225

16 trials · From ClinicalTrials.gov, checked 10 November 2026. Ask the study team whether a trial fits you.

Phase 1Taking people
A Study of LY4256984 in Participants With Sporadic Amyotrophic Lateral Sclerosis
Where
Calgary, Edmonton, London, Montreal, Toronto
Age
18 years to 75 years
People
36 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07100119 · EU 2025-521295-60-00
Phase 3Taking people
Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS
Where
Edmonton, Hamilton, Montreal
Age
18 years to 80 years
People
500 worldwide
Run by
Prilenia
See details and how to joinNCT07322003
Phase 1Not yet taking people in Canada
A Study of LY3873862 in Participants With Sporadic or Familial Amyotrophic Lateral Sclerosis (ALS).
Where
Montreal
Age
18 years to 75 years
People
32 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07883590
Phase 2Taking people
A Study to Assess the Safety, Tolerability, and Pharmacology of Darifenacin in Patients With ALS
Where
Montreal, Ottawa
Age
18 years to 85 years
People
60
Run by
Oliver Blanchard
See details and how to joinNCT06249867
No phaseTaking people
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)
Where
Toronto, Vancouver
Age
18 years and over
People
2,100 worldwide
Run by
Mayo Clinic
See details and how to joinNCT04363684
Phase 1Taking people
A Substudy of LY4256984 in Participants With Sporadic Amyotrophic Lateral Sclerosis
Where
Calgary, London, Montreal, Toronto
Age
18 years to 80 years
People
32 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07571174
Phase 1Taking people
A Master Protocol (OLMP): A Study of LY4256984 in Participants With Amyotrophic Lateral Sclerosis (ALS)
Where
Calgary, London, Montreal, Toronto
Age
18 years to 80 years
People
32 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07571200 · EU 2026-525574-19-00
No phaseTaking people
Effects of Probiotics in Amyotrophic Lateral Sclerosis-Frontotemporal Dementia Spectrum Disorder (ALS-FTDSD) Patients
Where
Fredericton, Montreal, Saskatoon
Age
18 years and over
People
150
Run by
Centre hospitalier de l'Université de Montréal (CHUM)
See details and how to joinNCT06051123
Phase 1/2Taking people
A Clinical Trial to Evaluate NB-4746 in Participants With Amyotrophic Lateral Sclerosis.
Where
Fredericton, Montreal, Toronto
Age
18 years to 80 years
People
80 worldwide
Run by
Nura Bio
See details and how to joinNCT07369076
Phase 1/2Taking people
First in Human (FIH) Study of ALN-SOD in Adult Participants With Amyotrophic Lateral Sclerosis Associated With Mutation in the SOD1 Gene (SOD1-ALS)
Where
Edmonton, London, Montreal, Toronto
Age
18 years and over
People
54 worldwide
Run by
Regeneron Pharmaceuticals
See details and how to joinNCT06351592 · EU 2023-510344-20-00
Phase 2Taking people
Usnoflast Neuromuscular Investigation for Treatment Efficacy in Amyotrophic Lateral Sclerosis
Where
Québec, Toronto
Age
18 years and over
People
240 worldwide
Run by
Zydus Therapeutics Inc.
See details and how to joinNCT07023835 · EU 2025-522580-15-00
Phase 1Taking people
AMX0114 in Adult Participants With Amyotrophic Lateral Sclerosis
Where
Calgary, Hamilton, London, Montreal
Age
18 years and over
People
48 worldwide
Run by
Amylyx Pharmaceuticals Inc.
See details and how to joinNCT06665165
No phaseTaking people
Comprehensive Analysis Platform To Understand, Remedy and Eliminate ALS
Where
Edmonton, Montreal, Québec, Toronto
Age
18 years and over
People
150
Run by
University of Alberta
See details and how to joinNCT05204017
No phaseTaking people
CAN-PRIME: Precise Robotically Implanted Brain-Computer Interface for the Control of External Devices
Where
Toronto
Age
19 years and over
People
6
Run by
Neuralink Corp
See details and how to joinNCT06700304
No phaseTaking people
Diagnosing Frontotemporal Lobar Degeneration
Where
Toronto
Age
18 years to 90 years
People
100
Run by
University Health Network, Toronto
See details and how to joinNCT02964637
No phaseTaking people
Quantitative and Repetitive TMS in ALS - Recruiting for Stage 2
Where
Toronto
Age
18 years and over
People
15
Run by
Sunnybrook Health Sciences Centre
See details and how to joinNCT05983211