Amyloidosis: open trials in Germany

30 open trials have a site in Germany. Registry data; only the trial team decides who can take part.

NCT06128629
MAGNITUDE: A Phase 3 Study of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM)
Trial Treatment · Phase 3 · Intellia Therapeutics
Charite Universitaetsmedizin Berlin KöR, Berlin · Universitaetsklinikum Essen (AoR), Essen · Universitaetsklinikum Heidelberg AöR, Heidelberg · Klinikum der Universitaet Muenchen AöR, Munich · Universitaetsklinikum Wuerzburg AöR, Wuerzburg
Registry updated 2026-11-04
NCT06978660
Multicenter Study for the Validation of an AI-based ECG Platform for Early Cardiac Amyloidosis Diagnosis
Research · Idoven 1903 S.L.
Universitätsklinikum Bonn, Bonn · TUM Klinikum Deutsches Herzzentrum, München
Registry updated 2026-11-04
NCT07207811
CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) Amyloidosis
Trial Treatment · Phase 3 · Novo Nordisk A/S
Universitätsklinik Der Ruhr-Universität Bochum, Bad Oeynhausen · Charité - Universitaetsmedizin Berlin, Berlin · Universitaetsklinikum Koeln, Cologne · Universitätsklinikum Carl Gustav Carus, Dresden · University Hospital Frankfurt, Frankfurt am Main · University Heart Center Freiburg, Freiburg im Breisgau · Universitaetsklinikum Jena, Jena · Universitaetsklinikum Schleswig-Holstein, Kiel · Deutsches Herzzentrum Muenchen, München · University of Munich (LMU)-Grosshadern Hospital, Munich · Universitaetsklinikum Muenster, Münster · University of Wurzburg, Comprehensive Heart Failure Center (CHFC), Würzburg
Registry updated 2026-10-21
NCT07052903
TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy
Trial Treatment · Phase 3 · Alnylam Pharmaceuticals
Charite Universitaetsmedizin Berlin KöR, Berlin · University Hospital Cologne AöR, Cologne · Herzzentrum Dresden GmbH Universitaetsklinik, Dresden · Universitaetsklinikum Erlangen AöR, Erlangen · Universitaetsmedizin Goettingen, Goettingen · Medizinische Hochschule Hannover, Hanover · Universitaetsklinikum Heidelberg AöR, Heidelberg · Universitaet Leipzig, Leipzig · Otto Von Guericke Universitaet Magdeburg, Magdeburg · Universitaet Muenster, Muenster · LMU Klinikum Muenchen AöR, Munich · Universitaetsklinikum Wuerzburg AöR, Wuerzburg
Registry updated 2026-10-20
NCT06075823
Edge-to-edge Mitral Valve Repair in ATTR-CM
Trial Treatment · Medical University of Vienna
Hannover Medical School, Department of Cardiology and Angiology, Hanover · University Hospital Heidelberg, Department of Cardiology, Angiology and Respiratory Medicine, Heidelberg · LMU University Hospital, Department of Medicine I, München
Registry updated 2026-10-16
NCT07298044
A Study to Learn More About the Change in the Blood Levels of Transthyretin When Participants With Transthyretin Amyloidosis With Cardiomyopathy Switch From Tafamidis to Acoramidis
Trial Treatment · Phase 4 · Bayer
Sana Klinikum Lichtenberg - Klinik für Innere Medizin II, Schwerpunkt Kardiologie, Berlin · Universitätsklinikum Bonn - Herzzentrum des Universitätsklinikums Bonn, Bonn · KVZ Kardiovaskulaeres Zentrum Darmstadt GmbH, Darmstadt · Universitaetsmedizin Greifswald KöR- Klinik und Poliklinik für Innere Medizin B, Greifswald · Universitätsklinikum Hamburg Eppendorf (UKE)-Universitären Herz- und Gefäßzentrum Hamburg, Klinik für Kardiologie, Hamburg · Universitaetsklinikum Ulm | Klinik fuer Innere Medizin II, Ulm
Registry updated 2026-10-15
NCT04561518
ConTTRibute: A Global Observational Study of Patients With Transthyretin (TTR)-Mediated Amyloidosis (ATTR Amyloidosis)
Research · Alnylam Pharmaceuticals
Berlin · Giessen · Hanover
Registry updated 2026-10-13
NCT07358078
DemonsTTRate: A Global, Observational, Multicenter, Long-term Study of Patients With ATTR-CM in a Real-World Setting
Research · Alnylam Pharmaceuticals
Heidelberg · Munich · Münster · Würzburg
Registry updated 2026-10-09
NCT05040373
Patisiran-Lipid Nanoparticle (LNP) Pregnancy Surveillance Program
Research · Alnylam Pharmaceuticals
Münster
Registry updated 2026-10-08
NCT07223203
TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy
Trial Treatment · Phase 3 · Alnylam Pharmaceuticals
Charite Universitaetsmedizin Berlin KöR, Berlin · Universitaetsklinikum Heidelberg AöR, Heidelberg · Universitaet Muenster, Muenster
Registry updated 2026-10-08
NCT07235462
A Study to Learn About the Use of Acoramidis in Patients With a Heart Condition Called Transthyretin Amyloid Cardiomyopathy (ATTR-CM) in a Real-world Setting
Research · Bayer
Many locations, Multiple Locations
Registry updated 2026-10-08
NCT06465810
Non-interventional Study of Patients With Transthyretin (ATTR) Amyloidosis
Research · AstraZeneca
Aachen · Berlin · Cologne · Frankfurt am Main · Hanover · Homburg · Mainz · Würzburg
Registry updated 2026-09-23
NCT07654855
Long-term Safety of Eplontersen Treated aTTR Patients and in Liver Transplant and Severely Hepatic Impaired Subpopulations
Research · AstraZeneca
Hanover
Registry updated 2026-09-14
NCT06355934
OverTTuRe: Characteristics, Treatment Patterns and Outcomes of Patients With ATTR Amyloidosis
Research · AstraZeneca
Berlin
Registry updated 2026-09-09
NCT07752732
Non-Interventional Study on the Prevalence of Cardiac Amyloidosis in Patients With Higher-Grade Aortic Valve Stenosis - Evaluation Using Echocardiography, Computed Tomography, Tc99-SPECT/CT and Cardiac Magnetic Resonance Imaging (CMR)
Research · University Hospital Tuebingen
University Hospital of Tuebingen, Tübingen
Registry updated 2026-09-02
NCT07205666
The Eplontersen Pregnancy and Lactation Outcomes Study
Research · AstraZeneca
Frankfurt
Registry updated 2026-08-27
NCT06292780
A Trial to Learn if Linvoseltamab is Safe and Works in Adults With Relapsed or Refractory Systemic Light Chain Amyloidosis (AL Amyloidosis)
Trial Treatment · Phase 1/2 · Regeneron Pharmaceuticals
Charite Universitaetsmedizin Berlin KöR, Berlin · Universitaetsklinikum Essen (AoR), Essen · Universitaetsklinikum Heidelberg AöR, Heidelberg · Universitaetsklinikum Wuerzburg AöR, Wuerzburg
Registry updated 2026-08-18
NCT07116473
To Evaluate the Long-term Safety and Tolerability of Acoramidis in Participants With Newly Diagnosed ATTR-CM (ACT-EARLY OLE)
Trial Treatment · Phase 3 · Eidos Therapeutics, a BridgeBio company
Charite Universitaetsmedizin Berlin KöR, Berlin · Universitaetsklinikum Heidelberg AöR, Heidelberg · Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöR, Mainz
Registry updated 2026-08-11
NCT06563895
Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant
Trial Treatment · Phase 3 · Eidos Therapeutics, a BridgeBio company
Charite Universitaetsmedizin Berlin KöR, Berlin · Universitaetsklinikum Heidelberg AöR, Heidelberg · Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöR, Mainz
Registry updated 2026-08-04
NCT07577466
Screening, Characterization, and Longitudinal Follow-up of Patients With Cardiac Amyloidosis
Research · Heinrich-Heine University, Duesseldorf
University Hospital Duesseldorf, Düsseldorf
Registry updated 2026-05-11
NCT05667493
An Extension Study to Assess Long-Term Safety of Eplontersen in Adults With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM)
Trial Treatment · Phase 3 · Ionis Pharmaceuticals, Inc.
Uniklinik Köln, Cologne · Universitaetsklinikum Heidelberg - Zentrum für Innere Medizin, Heidelberg · Universitätsklinikum des Saarlandes, Homburg · Universitätsklinikum Münster, Münster · Universitätsklinikum Würzburg, Würzburg
Registry updated 2026-04-17
NCT06205953
A EUropean REgistry and Sample Sharing networK to Promote the Diagnosis and Management of Light Chain Amyloidosis (EUREKA)
Research · Fondazione IRCCS Policlinico San Matteo di Pavia
Medical Department, Amyloidosis Center, University Hospital, Im Neuenheimer Feld 672, Heidelberg
Registry updated 2026-04-16
NCT07359690
Multimodal Analysis of Endomyocardial Biopsies
Research · University Hospital, Essen
Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center Essen, University Hospital Essen, Germany, Essen
Registry updated 2026-01-22
2025-520790-39-00
CLonE-specific CAR T-Cell therapy in relapsed or refractory AL amyloidosis - a single-center Phase I trial (CLEAR AL)
Trial Treatment · Phase 1 · Universitaetsklinikum Heidelberg AöR
Universitaetsklinikum Heidelberg AöR, Heidelberg
Registry updated 2025-11-25
NCT07154381
Hybrid Florbetaben PET/MRI for Imaging of Cardiac Amyloidosis
Research · University Hospital, Essen
Department of Nuclear medicine, University Hospital Essen, Essen
Registry updated 2025-09-04

All Amyloidosis trials and the map

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