Bipolar disorder: open trials in United States

• NCT07286175

  A Study of Brenipatide in Adult Participants With Bipolar Disorder (RENEW-Bipolar-1)

  Trial Treatment · Phase 2 · Eli Lilly and Company

  Atlanta Center for Medical Research, Atlanta · Northwest Clinical Research Center, Bellevue · Alpine Research Organization, Clinton · Re:Cognition Health, Fairfax · CBH Health, Gaithersburg · AGA Clinical Trials, Hialeah · Accel Research Sites - Maitland Clinical Research Unit, Maitland · K2 Medical Research - Maitland, Maitland · Revival Research Institute, LLC, McKinney · Floridian Clinical Research, LLC, Miami Lakes · CLA Research, Naples · Yale University School Of Medicine, New Haven · ATP Clinical Research, Orange · Charter Research - Orlando, Orlando · Penn Medicine: University of Pennsylvania Health System, Philadelphia · Pillar Clinical Research - Richardson, Richardson · Elixia MA, Springfield · Covenant Medical Center, Waterloo · Adams Clinical Watertown, Watertown · Encore Medical Research - Weston, Weston

  Registry updated 2026-11-04

• NCT06229210

  Safety and Tolerability Trial of Lumateperone in Pediatric Patients With Schizophrenia, Bipolar Disorder or Autism Spectrum Disorder

  Trial Treatment · Phase 3 · Intra-Cellular Therapies, Inc.

  Advanced Research Center, Inc., Anaheim · CenExeli Research LLC, Atlanta · Atlanta Behavioral Research, LLC, Atlanta · Atlanta Center for Medical Research, Atlanta · Quest Therapeutics of Avon Lake, Avon Lake · Northwest Clinical Research Center, Bellevue · NeuroBehavioral Medicine Group, Bloomfield Hills · University of Cincinnati Medical Center, Cincinnati · MCB Clinical Research Centers LLC, Colorado Springs · Texas Research Group, Coppell · Core Clinical Research, Everett · Royal Palm Clinical Research, Fort Myers · PsyMed Solutions, Fort Worth · Sarkis Clinical Trials, Gainesville · National Institute Of Clinical Research, Garden Grove · Charak Center for Health and Wellness, Garfield Heights · United Research Institute, Hialeah · Advanced Research Institute of Miami, Homestead · Kaleidoscope Clinical Research, Houston · Red Oak Psychiatry Associates, Houston · Riley Hospital for Children at Indiana University Health, Indianapolis · Green Leaf Clinical Trials, Jacksonville · Clinical Research of Southern Nevada, LLC, Las Vegas · Salveo Integrative Health Inc, Lawrenceville · Alivation Research, LLC, Lincoln · Pillar Clinical Research, LLC, Little Rock · AP Medical Research, Miami · Vital Care Research, Miami · Diverse Clinical Research LLC, Miami · Links Clinical Trials, Miami · Columbus Clinical Services LLC, Miami · Blue Medical Research, Miami · GTL Medical and Research Group, Miami · Care Research Center Inc, Miami · Envision Trials LLC, Miami · New Med Research Inc, Miami Gardens · The Angel Medical Research Corporation, Miami Gardens · Riveldi Biomedical Research, Miami Lakes · Baber Research Group, Naperville · Access Clinical Trials, Nashville · NYU Child Study Center, New York · Sooner Clinical Research, Norman · Excell Research, Inc., Oceanside · Cutting Edge Research Group, Oklahoma City · APG Research, LLC, Orlando · Southwest Autism Research and Resource Center, Phoenix · AIM Trials, Plano · Clinical Research Center of Florida, Pompano Beach · Inland Psychiatric Medical Group, Inc., Redlands · Virginia Commonwealth University, Richmond · Perceptive Pharma Research, Richmond · University of California - Davis, Sacramento · Midwest Research Group 1, Saint Charles · University of California San Diego, San Diego · CenExeli Research LLC 1, Savannah · Richmond Behavioral Associates, Staten Island · University of South Florida Rothman Center of Neuropsychiatry, St. Petersburg · Next Level Clinical Trials, LLC, West Covina · Health Synergy Clinical Research, West Palm Beach

  Registry updated 2026-11-03

• NCT06372964

  Multicenter Study of Lumateperone for the Treatment of Bipolar Depression in Pediatric Patients

  Trial Treatment · Phase 3 · Intra-Cellular Therapies, Inc.

  Advanced Research Center, Inc., Anaheim · Advanced Discovery Research, Atlanta · CenExeli Research LLC, Atlanta · BioBehavioral Research of Austin PC, Austin · The University of Texas at Austin, Austin · Haidar Almhana Nieding, Avon Lake · MTP Psychiatry, LLC, Baltimore · REX Clinical Trials LLC, Beaumont · Northwest Clinical Research Center, Bellevue · NeuroBehavioral Medicine Group, Bloomfield Hills · Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago · University of Cincinnati Medical Center, Cincinnati · MCB Clinical Research Centers LLC, Colorado Springs · Harmonex Neuroscience Research, Dothan · Revive Research Institute, Elgin · Core Clinical Research, Everett · North Pointe Psychiatry, Flower Mound · Royal Palm Clinical Research, Fort Myers · Charak Center for Health and Wellness, Garfield Heights · United Research Institute, Hialeah · Advanced Research Institute of Miami, Homestead · Red Oak Psychiatry Associates, Houston · Kaleidoscope Clinical Research, Houston · Indiana University, Indianapolis · Salveo Integrative Health Inc, Lawrenceville · Alivation Research, LLC, Lincoln · Pillar Clinical Research, LLC, Little Rock · GTL Medical and Research Group, Miami · AP Medical Research, Miami · SouthGen Clinical Research LLC, Miami · Care Research Center Inc, Miami · HealthMed Clinical Center Inc, Miami · Columbus Clinical Services LLC, Miami · Envision Trials LLC, Miami · Links Clinical Trials, Miami · Ocean Blue Medical Research Center Inc., Miami · Vital Care Research, Miami · New Med Research Inc, Miami Gardens · The Angel Medical Research Corporation, Miami Gardens · Riveldi Biomedical Research, Miami Lakes · NYU Child Study Center, New York · Sooner Clinical Research, Oklahoma City · Cutting Edge Research Group, Oklahoma City · SP Research, PLLC (dba Rivus Wellness & Research Institute), Oklahoma City · APG Research, LLC, Orlando · Inland Psychiatric Medical Group, Inc., Redlands · Virginia Commonwealth University, Richmond · Perceptive Pharma Research, Richmond · UC Davis Health System, Sacramento · Midwest Research Group, Saint Charles · University of California San Diego Medical Center, San Diego · CenExeli Research LLC 1, Savannah · Washington University School of Medicine Child and Adolescent Psychiatry Clinic, St Louis · Next Level Clinical Trials, LLC, West Covina · Westlake America Clinic, Westlake · Health Synergy Clinical Research, West Palm Beach

  Registry updated 2026-11-03

• NCT06462196

  Natural History of Depression, Bipolar Disorder and Suicide Risk

  Research · National Institute of Mental Health (NIMH)

  National Institutes of Health Clinical Center, Bethesda

  Registry updated 2026-11-03

• NCT07140913

  A Study to Evaluate the Efficacy and Safety of Adjunctive KarXT for the Treatment of Mania, With or Without Mixed Features, in Participants With Bipolar-I Disorder Taking Lithium, Valproate, or Lamotrigine

  Trial Treatment · Phase 3 · Bristol-Myers Squibb

  Community Clinical Research, Austin · Clinical Innovations, Inc. dba CITrials, Bellflower · Pillar Clinical Research - Bentonville, Bentonville · Health Synergy Clinical Research, Boynton Beach · Pillar Clinical Research -Chicago, Chicago · Inland Psychiatric Medical Group., Chino · ProScience Research Group, Culver City · Adams Clinical Dallas, DeSoto · Hallandale · Elevate Clinical Research - Houston, Houston · Indianapolis · Omega Clinical Trials - La Habra, La Habra · Pillar Clinical Research - Little Rock, Little Rock · Prime Clinical Research - Mansfield, Mansfield · Miami · Catalina Research Institute, LLC, Montclair · NRC Research Institute, Orange · Pillar Clinical Research - Richardson, Richardson · Clinical Innovations, Inc. dba CITrials, Riverside · CenExel iResearch, LLC, Savannah · Richmond Behavioral Associates, Staten Island · Arch Clinical Trials, St Louis

  Registry updated 2026-11-03

• NCT07913542

  N-Acetylcysteine for Bipolar and Alcohol Use Disorders

  Trial Treatment · Phase 2 · Medical University of South Carolina

  Medical University of South Carolina, Charleston

  Registry updated 2026-11-03

• NCT06929273

  A Study to Assess the Long-term Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-3)

  Trial Treatment · Phase 3 · Bristol-Myers Squibb

  Advanced Research Center, Inc., Anaheim · Atlanta Center for Medical Research, Atlanta · Synexus Clinical Research US Inc, Atlanta · Community Clinical Research, Austin · Clinical Innovations, Inc. dba CITrials, Bellflower · Pillar Clinical Research - Richardson, Bentonville · Health Synergy Clinical Research, Boynton Beach · Carrollton · Cerritos · Cerritos · Charlotte · Chicago · Pillar Clinical Research -Chicago, Chicago · Inland Psychiatric Medical Group - Chino, Chino · University of Cincinnati Medical Center, Cincinnati · ProScience Research Group, Culver City · CenExel iResearch, LLC, Decatur · Adams Clinical Dallas, DeSoto · Precise Research Centers, Flowood · CBH Health, Gaithersburg · Collaborative NeuroScience Research , LLC, Garden Grove · Glendale · Velocity Clinical Research, Hallandale Beach, Hallandale · Hialeah Gardens · Behavioral Clinical Research, Hollywood · Research Centers of America ( Hollywood ), Hollywood · Houston · Elevate Clinical Research - Houston, Houston · Indianapolis · Irving · Omega Clinical Trials - La Habra, La Habra · Lincoln · Woodland International Research Group, Little Rock · Pillar Clinical Research - Little Rock, Little Rock · Prime Clinical Research - Mansfield, Mansfield · Hassman Research Institute Marlton Site, Marlton · Marlton · Advanced Research Institute of Miami, Miami · LCC Medical Research Institute, Miami · Innovative Clinical Research, Inc., Miami Lakes · South Florida Research Phase I - IV, Miami Springs · Catalina Research Institute, LLC, Montclair · Yale New Haven Hospital-Smilow Cancer Center, New Haven · Neuro-Behavioral Clinical Research, North Canton · North Las Vegas · North Las Vegas · Northridge · NRC Research Institute, Orange · Pillar Clinical Research - Richardson, Richardson · Clinical Innovations, Inc. dba CITrials, Riverside · Woodland Research Northwest, Rogers · Santa Ana · CenExel iResearch, LLC, Savannah · Scottsdale · Richmond Behavioral Associates, Staten Island · Arch Clinical Trials, St Louis · St. Petersburg · Collaborative Neuroscience Research LLC, Torrance · Tucson · West Chester · Wichita Falls

  Registry updated 2026-10-26

• NCT06951698

  A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder

  Trial Treatment · Phase 3 · Bristol-Myers Squibb

  Advanced Research Center, Inc., Anaheim · Synexus Clinical Research US Inc, Atlanta · Community Clinical Research, Austin · CITrials, Bellflower · Bentonville · Cerritos · Pillar Clinical Research -Chicago, Chicago · Research Centers of America ( Hollywood ), Hollywood · Advanced Research Institute of Miami, Homestead · Irving · Woodland International Research Group, Little Rock · Collaborative Neuroscience Research, LLC, Long Beach · NRC Research Institute, Los Angeles · South Florida Research Phase I-IV, Miami · Innovative Clinical Research, Inc., Miami Lakes · Miami Lakes · Catalina Research Institute, LLC, Montclair · Connecticut Mental Health Center, New Haven · Neuro-Behavioral Clinical Research, North Canton · Pillar Clinical Research - Richardson, Richardson · CenExel iResearch, LLC, Savannah · Richmond Behavioral Associates, Staten Island · Health Synergy Clinical Research, West Palm Beach

  Registry updated 2026-10-23

• NCT07130500

  Incentives and Long-Acting Injectable Adherence After Involuntary Hospitalization

  Trial Treatment · Stanford University

  UPMC Mon Yough, McKeesport · UPMC Western Psychiatric Hospital, Pittsburgh · UPMC Bellefield Towers, Pittsburgh · Pittsburgh Mercy, Pittsburgh · UPMC Oxford Building, Pittsburgh · UPMC Franklin Building, Pittsburgh

  Registry updated 2026-10-23

• NCT06951711

  A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-2)

  Trial Treatment · Phase 3 · Bristol-Myers Squibb

  Atlanta Center for Medical Research, Atlanta · Health Synergy Clinical Research, Boynton Beach · Charlotte · Chicago · University of Cincinnati Medical Center, Cincinnati · ProScience Research Group, Culver City · CenExel iResearch, LLC, Decatur · Adams Clinical Dallas, DeSoto · Precise Research Centers, Flowood · CBH Health, Gaithersburg · Hialeah Gardens · Behavioral Clinical Research, Hollywood · Houston · Pillar Clinical Research - Little Rock, Little Rock · Hassman Research Institute Marlton Site, Marlton · Marlton · LCC Medical Research Institute, Miami · Innovative Clinical Research, Inc., Miami Lakes · South Florida Research Phase I - IV, Miami Springs · Neuro-Behavioral Clinical Research, North Canton · North Las Vegas · Pillar Clinical Research, Richardson · Pillar Clinical Research - Richardson, Richardson · Clinical Innovations, Inc. dba CITrials, Riverside · Woodland Research Northwest, Rogers · Arch Clinical Trials, St Louis · Tampa · Collaborative Neuroscience Research LLC, Torrance

  Registry updated 2026-10-20

• NCT06656416

  ALTO-100 in Bipolar Disorder With Depression (BD-D)

  Trial Treatment · Phase 2 · Alto Neuroscience

  Albuquerque · Albuquerque · Amherst · Ann Arbor · Ann Arbor · Atlanta · Atlanta · Austin · Baltimore · Beaumont · Bel Air · Bellevue · Birmingham · Carmel · Cary · Chandler · Chicago · Chino · Cincinnati · Colorado Springs · Dallas · Dallas · Draper · Fairfax · 6039, Fayetteville · Flowood · Gaithersburg · Grand Rapids · Houston · Houston · Imperial · Jacksonville · Las Vegas · Las Vegas · Lauderhill · Lincoln · 6070, Little Rock · Little Rock · 6069, Los Angeles · Mather · New York · 6065, North Canton · Oceanside · Peachtree Corners · Phoenix · Pinellas Park · Plano · Riverside · Rose Hill · Sacramento · San Jose · Tampa · Toms River · Towson · West Lafayette · Westlake · Worcester · Yuma

  Registry updated 2026-10-13

• NCT03829787

  Attentional Biases, Reward Sensitivity, and Cognitive Control in Adults With Bipolar Disorder

  Research · University Hospitals Cleveland Medical Center

  University Hospitals Cleveland Medical Center - Mood Disorders Program, Cleveland

  Registry updated 2026-10-09

• NCT05669703

  NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder

  Research · National Institute of Mental Health (NIMH)

  National Institutes of Health Clinical Center, Bethesda

  Registry updated 2026-10-07

• NCT07211217

  Time Restricted Eating (TRE) in Bipolar Disorder

  Trial Treatment · Massachusetts General Hospital

  Massachusetts General Hospital, Boston

  Registry updated 2026-10-07

• NCT07570875

  Evaluating the Impact of Ketogenic Therapy on Symptom Severity and Metabolic Side Effect Profile Among Individuals Living With Bipolar Disorder in A Rural Southern Catchment Area

  Trial Treatment · University of Alabama at Birmingham

  Baptist Medical Center South, Montgomery

  Registry updated 2026-10-07

• NCT00024635

  Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers

  Research · National Institute of Mental Health (NIMH)

  National Institutes of Health Clinical Center, Bethesda

  Registry updated 2026-10-02

• NCT05491538

  Acceptability and Feasibility of Work-Oriented Social-Cognitive Skills Training for Veterans With Serious Mental Illness

  Trial Treatment · VA Office of Research and Development

  Minneapolis VA Health Care System, Minneapolis, MN, Minneapolis

  Registry updated 2026-10-02

• NCT05648591

  Safety and Tolerability of Open-Labeled Iloperidone in Adolescents

  Trial Treatment · Phase 4 · Vanda Pharmaceuticals

  Atlanta · Cincinnati · Decatur · Denver · Dothan · Everett · Garfield Heights · Kinston · Little Rock · Westlake

  Registry updated 2026-10-01

• NCT05703412

  Effectiveness of mHealth Post-discharge Intervention for Patients With Severe Mental Illness

  Trial Treatment · Butler Hospital

  Butler Hospital, Providence

  Registry updated 2026-09-29

• NCT07288320

  An Assessment of Efficacy, Safety, and Pharmacokinetics of NBI-1117568 in Adults With Bipolar I Disorder With Current Mania

  Trial Treatment · Phase 2 · Neurocrine Biosciences

  Atlanta · Austin · Cerritos · Gaithersburg · Garden Grove · Hollywood · Houston · Little Rock · Marlton · San Diego · Staten Island

  Registry updated 2026-09-29

• NCT07845409

  Targeted Alternating Current and Cognitive Training Intervention for Cognitive Control in Bipolar Disorders

  Trial Treatment · VA Office of Research and Development

  Minneapolis VA Health Care System, Minneapolis, MN, Minneapolis

  Registry updated 2026-09-28

• NCT00025935

  Studies of Brain Function and Course of Illness in Pediatric Bipolar Disorder

  Research · National Institute of Mental Health (NIMH)

  National Institutes of Health Clinical Center, Bethesda

  Registry updated 2026-09-23

• NCT07680153

  Neuromodulation of Mood Switch Circuitry in Bipolar Disorder

  Trial Treatment · Phase 4 · Weill Medical College of Cornell University

  Weill Cornell Medicine, New York

  Registry updated 2026-09-23

• NCT07745374

  Safety and Feasibility of DBS for Bipolar Depression

  Trial Treatment · Icahn School of Medicine at Mount Sinai

  Center for Advanced Circuit Therapeutics, Clinical Neurosciences Center, Mount Sinai West, New York

  Registry updated 2026-09-22

• NCT07834203

  State Representation in Early Psychosis 2

  Research · University of Minnesota

  University of Minnesota Ambulatory Research Center, Minneapolis · University of Minnesota Department of Psychology, Minneapolis

  Registry updated 2026-09-22

All Bipolar disorder trials and the map

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