Bipolar disorder trials in United States

In United States 94 Also abroad 235

94 trials · From ClinicalTrials.gov, checked 10 November 2026. Ask the study team whether a trial fits you.

Phase 4Taking people
A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor
Where
Augusta, Austin, Bonita Springs, Bryant, Chino, Fresno, Hialeah, Independence, Long Beach, Miami, Naperville, Omaha, Orange, Orange City, Port Charlotte, Redlands, Richmond, San Diego, Tampa
Age
18 years and over
People
100
Run by
Neurocrine Biosciences
See details and how to joinNCT07105111
Phase 1Taking people
A Study to Assess Adverse Events and How Oral ABBV-932 Moves Through the Body When Given With Oral Itraconazole in Adult Participants With Bipolar Disorder
Where
Grayslake, Los Alamitos
Age
18 years to 65 years
People
20
Run by
AbbVie
See details and how to joinNCT07071532
Phase 4Taking people
The Effects of Lumateperone on Obesity and Physiologic Aging and Their Association With Antidepressant Response in Bipolar Depression
Where
Boston
Age
18 years to 65 years
People
25
Run by
Massachusetts General Hospital
See details and how to joinNCT07699445
Phase 4Not yet taking people in United States
Broadband Near Infrared Spectroscopy to Understand the Role of Brain Cytochrome C Oxidase in Bipolar Disorder
Where
New York
Age
18 years to 60 years
People
60
Run by
Martin Lan
See details and how to joinNCT07806227
No phaseTaking people
Cerebellar Modulation of Cognition in Psychosis
Where
Belmont, Boston
Age
18 years to 55 years
People
95
Run by
Mclean Hospital
See details and how to joinNCT06107764
No phaseTaking people
Enhancing Veteran-Clinical Collaboration in VA PRRCs
Where
Albuquerque, San Diego, West Los Angeles
Age
18 years and over
People
119
Run by
VA Office of Research and Development
See details and how to joinNCT06898879
No phaseTaking people
Ketogenic and Nutritional Interventions for First Episode Bipolar Disorder
Where
Belmont
Age
18 years to 45 years
People
50
Run by
Mclean Hospital
See details and how to joinNCT06221852
No phaseEnrolling by invitation
Open Label Extension Study of NCT06221852
Where
Belmont
Age
18 years to 45 years
People
50
Run by
Mclean Hospital
See details and how to joinNCT06558201
No phaseTaking people
Ketogenic Intervention for Bipolar Depression
Where
Rochester
Age
18 years to 50 years
People
30
Run by
Mayo Clinic
See details and how to joinNCT07121894
Phase 3Enrolling by invitation
Long-term Safety Extension Study of OLZ/SAM in Pediatric Subjects
Where
Chicago, Cincinnati, Decatur, Dothan, Everett, Indianapolis, Lincoln, Little Rock, Miami Lakes, New York, Richmond, Saint Charles, Stanford, Washington D.C., West Chester
Age
10 years to 17 years
People
236 worldwide
Run by
Alkermes, Inc.
See details and how to joinNCT04987229
Phase 3Taking people
Study to Evaluate Weight Gain as Assessed by Change in BMI Z-score in Pediatric Subjects With Schizophrenia or Bipolar I Disorder
Where
Chicago, Cincinnati, Colorado Springs, Decatur, Denver, DeSoto, Dothan, Encino, Everett, Fort Worth, Hartford, Indianapolis, Kinston, Lincoln, Little Rock, Miami, Miami Lakes, New York, Omaha, Paramus, Richmond, Saint Charles, Stanford, Upland, Washington D.C., West Chester
Age
10 years to 17 years
People
220 worldwide
Run by
Alkermes, Inc.
See details and how to joinNCT05303064
Phase 2Taking people
A Study to Assess Adverse Events and Change in Disease Activity of Oral Icalcaprant in Adult Participants With Bipolar I or II Disorder
Where
Anaheim, Atlanta, Austin, Bellevue, Bryant, Chandler, Chicago, Cincinnati, Columbus, Everett, Gainesville, Garden Grove, Hollywood, Houston, Huntsville, Largo, Missouri City, Montclair, New York, Oceanside, Oklahoma City, Orange, Orlando, Pompano Beach, Richardson, Saint Augustine, Saint Charles, Sherman Oaks, The Woodlands, Tucson, Warrenville, West Palm Beach
Age
18 years to 65 years
People
195
Run by
AbbVie
See details and how to joinNCT06696755
Phase 2Taking people
Acceptability & Safety of Two Sequential Doses of Psilocybin in Bipolar Disorder II Depression and Suicidality
Where
Houston
Age
25 years to 70 years
People
10
Run by
The University of Texas Health Science Center, Houston
See details and how to joinNCT06706232
Phase 1Taking people
Determining Efficacy and Safety of BXCL501 in Agitation Associated With Pediatric Schizophrenia and Bipolar Disorder
Where
Anaheim, Atlanta, Decatur, DeSoto, Hialeah
Age
10 years to 17 years
People
140
Run by
BioXcel Therapeutics Inc
See details and how to joinNCT05025605
No phaseTaking people
Healthy Lifestyles for Bipolar Disorder
Where
Berkeley
Age
18 years to 65 years
People
300
Run by
University of California, Berkeley
See details and how to joinNCT06188754
No phaseNot yet taking people in United States
Senyo Health App - Comorbid Alcohol Use Disorder Treatment in Individuals With Bipolar Disorder Using a Telehealth Collaborative Care Platform
Where
Rochester
Age
18 years and over
People
40
Run by
Mayo Clinic
See details and how to joinNCT07556861
Phase 1/2Taking people
A Study to Investigate Lithium Brain/Plasma Pharmacokinetics and Safety of an AL001 Oral Capsule Compared to a Marketed Immediate-release Lithium Carbonate Capsule in Subjects With Bipolar I Disorder
Where
Boston
Age
18 years to 65 years
People
20
Run by
Alzamend Neuro, Inc.
See details and how to joinNCT07540338
Phase 3Taking people
A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.
Where
Anaheim, Atlanta, Austin, Avon Lake, Baltimore, Beaumont, Bellaire, Bentonville, Beverly Hills, Bountiful, Buffalo, Chicago, Chino, Cincinnati, Cleveland, Coppell, Culver City, Dallas, Decatur, Doral, Dunwoody, Everett, Friendswood, Garden Grove, Homestead, Houston, Indianapolis, Irvington, Kinston, Long Beach, Mansfield, Miami, Miami Springs, Mount Arlington, Naperville, Oklahoma City, Orange, Orange City, Orlando, Orland Park, Pensacola, Plano, Rancho Cucamonga, Redlands, Richmond, Sacramento, San Diego, San Jose, Shreveport, Stockbridge, Stone Mountain, Tamarac, Tampa, The Woodlands, Upland, West Chester, West Covina
Age
10 years to 17 years
People
380 worldwide
Run by
AbbVie
See details and how to joinNCT04777357
Phase 2Taking people
Multicenter Study to Assess the Efficacy and Safety of LB-102 in the Treatment of Adult Patients With BP1MDE.
Where
Atlanta, Bellevue, Bellflower, Bentonville, Canton, Chicago, Culver City, Decatur, DeSoto, Detroit, Doral, Garden Grove, Hollywood, Las Vegas, Lemon Grove, Little Rock, Los Angeles, Miami Lakes, New York, Orange, Philadelphia, Richardson, Riverside, St Louis, Torrance, West Palm Beach
Age
18 years to 65 years
People
320
Run by
LB Pharmaceuticals Inc.
See details and how to joinNCT07494305
Phase 3Taking people
Cognitive Strategies in Early Psychosis 2
Where
Minneapolis
Age
18 years to 35 years
People
24
Run by
University of Minnesota
See details and how to joinNCT07263022
No phaseTaking people
Transition Care for FEP
Where
Chicago, Harvey
Age
18 years to 40 years
People
75
Run by
University of Chicago
See details and how to joinNCT07713849
No phaseTaking people
Intermittent Theta Burst Stimulation (iTBS) for Emotion Regulation in Bipolar Disorder
Where
Charlestown, Philadelphia
Age
24 years to 65 years
People
136
Run by
Massachusetts General Hospital
See details and how to joinNCT06274567
Phase 4Taking people
Exercise and Olanzapine-samidorphan
Where
New York
Age
18 years to 65 years
People
30
Run by
New York State Psychiatric Institute
See details and how to joinNCT06740890
No phaseTaking people
A Novel Peer-Delivered Recovery-Focused Suicide Prevention Intervention for Veterans With Serious Mental Illness
Where
San Diego
Age
18 years and over
People
69
Run by
VA Office of Research and Development
See details and how to joinNCT05537376
No phaseTaking people
Exercise-based Program for Rehabilitation of Veterans With Severe Mental Illness
Where
Pittsburgh
Age
18 years to 70 years
People
112
Run by
VA Office of Research and Development
See details and how to joinNCT05157620