Bladder cancer trials in United States

In United States 259 Also abroad 626

259 trials · From ClinicalTrials.gov, checked 12 November 2026. Ask the study team whether a trial fits you.

Phase 1Taking people
Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors
Where
Augusta, Birmingham, Boston, Chicago, Detroit, Duarte, East Brunswick, Fairfax, Fort Worth, Houston, Lake Success, Los Angeles, Miami, Mineola, Nashville, New York, Orlando, Portland, San Antonio, San Diego, St Louis, Zion
Age
18 years and over
People
280
Run by
SystImmune Inc.
See details and how to joinNCT06293898
Phase 1Taking people
Study of GB-4362 With Enfortumab Vedotin and Pembrolizumab for Advanced Urothelial Cancer
Where
Charlottesville, Duarte, Houston, Irvine, Lake Success, New Brunswick, New York, Orlando, Tucker, Zion
Age
18 years and over
People
37
Run by
Generate Biomedicines
See details and how to joinNCT07484022
Phase 1Taking people
A Phase 1 Dose-escalation Study of UGN-501 Administered Intravesically in Adult Participants With Recurrent NMIBC
Where
Arlington, Aurora, Austin, Bakersfield, Boston, Miami, Murrieta, Myrtle Beach, Omaha, Philadelphia, Portland, Queen Creek, Syracuse, The Woodlands, Troy
Age
18 years and over
People
30
Run by
UroGen Pharma, Inc., a subsidiary of UroGen Pharma Ltd.
See details and how to joinNCT07725796
Phase 1/2Taking people
A Study to Evaluate ARV-6723 Alone and With Pembrolizumab in Participants With Advanced Solid Tumors
Where
Fairfax, Huntersville, New York, San Antonio
Age
18 years and over
People
499
Run by
Arvinas Inc.
See details and how to joinNCT07749586 · EU 2026-525614-57-00
Phase 1/2Taking people
In-home Intravesical Chemotherapy for the Treatment of Bladder Cancer, INVITE Trial
Where
Jacksonville
Age
18 years and over
People
40
Run by
Mayo Clinic
See details and how to joinNCT06704191
Phase 1/2Taking people
Symbiotic-GU-06: A Study to Learn About PF-08634404 Alone or In Combination With Enfortumab Vedotin in Urothelial Cancer
Where
Albany, Alhambra, Atascadero, Aurora, Austin, Baltimore, Basking Ridge, Beaumont, Beverly Hills, Blacksburg, Burbank, Cary, Chattanooga, City of Saint Peters, Cleveland, Clifton Park, Commack, Cookeville, Creve Coeur, Denver, Derby, Dickson, Duarte, Durham, Edmonds, Encinitas, Encino, Eugene, Fairfax, Fairfield, Fayetteville, Florissant, Franklin, Gallatin, Greenwich, Guilford, Harlingen, Harrison, Hendersonville, Houston, Irvine, Irving, Kirkland, Laguna Hills, La Jolla, Lebanon, Lone Tree, Long Beach, Long Island City, Los Angeles, Low Moor, Marina del Rey, McAllen, Middletown, Montvale, Mount Juliet, Murfreesboro, Nashville, New Haven, New York, Norfolk, North Haven, Norwich, Orange, Pasadena, Pearland, Porter Ranch, Portland, Raleigh, Ringgold, Roanoke, Rogers, Salem, Salt Lake City, San Diego, San Luis Obispo, Santa Barbara, Santa Monica, Seattle, Shelbyville, Shiloh, Smyrna, Springdale, Springfield, Stamford, St Louis, Sugar Land, The Woodlands, Tigard, Torrance, Trumbull, Uniondale, Upland, Valencia, Vancouver, Ventura, Vista, Waco, Washington D.C., Webster, Weslaco, Westlake Village, Wytheville
Age
18 years and over
People
132 worldwide
Run by
Pfizer
See details and how to joinNCT07421700 · EU 2025-523523-21-00
Phase 2Not yet taking people in United States
A Study of Vepugratinib (LY3866288) in Adults With Non-Muscle Invasive Bladder Cancer and Upper Tract Urothelial Cancer
Where
Myrtle Beach
Age
18 years and over
People
161
Run by
Eli Lilly and Company
See details and how to joinNCT07827612
Phase 2Taking people
Consolidative Local Therapy (CLT) in Oligo-metastatic Urothelial Carcinoma
Where
Madison, New Haven
Age
18 years and over
People
32
Run by
Yale University
See details and how to joinNCT07048457
Phase 3Taking people
A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract
Where
Austin, Baltimore, Baton Rouge, Baytown, Boise, Boston, Charlotte, Chicago, Cincinnati, Columbus, Dallas, Denver, Detroit, East Brunswick, Evanston, Fort Wayne, Frederick, Grand Junction, Houston, Indianapolis, Irvine, Lancaster, Las Vegas, Lexington, Lisle, Little Rock, Los Angeles, McAllen, Metairie, Nashville, New Haven, New Orleans, New York, Norfolk, Orange, Orlando, Pittsburgh, Portland, Rochester, Sacramento, San Francisco, Sioux Falls, Springfield, St Louis, The Woodlands, Torrance, Tucson, Tyler, Washington D.C., Winston-Salem, Worcester
Age
18 years and over
People
450 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07218380 · EU 2025-522855-25-00
No phaseTaking people
Measuring Surgical Recovery After Radical Cystectomy
Where
Atlanta, Baltimore, Chicago, Dallas, Grand Rapids, Houston, Lawrence, Mineola, Rochester, Stanford
Age
18 years and over
People
2,000
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT03193970
Phase 1/2Taking people
Radiation Combined With BIspecific T-Cell Engager in DLL3 Expressing Tumors
Where
Gilbert, Seattle, Tucson
Age
18 years to 99 years
People
30
Run by
University of Arizona
See details and how to joinNCT06814496
Phase 3Taking people
Efficacy and Safety of Intravesical TARA-002 Compared With Investigator's Choice of Intravesical Chemotherapy in Participants With BCG-naïve High-grade Non-muscle Invasive Bladder Cancer
Where
Arlington, Atlanta, Austin, Bakersfield, Houston, Little Rock, Myrtle Beach, Queen Creek, St Louis
Age
18 years and over
People
284 worldwide
Run by
Protara Therapeutics
See details and how to joinNCT07480356
Phase 2Taking people
A Trial of Durvalumab (MEDI4736) Plus Monalizumab in Non-Muscle-Invasive Bladder Cancer
Where
New Brunswick, New York, San Francisco, Tampa
Age
18 years and over
People
60
Run by
John Sfakianos
See details and how to joinNCT06503614
No phaseTaking people
Intravesical Treatment of Bladder Cancer at Home, Multi-modal Treatment Support
Where
Philadelphia
Age
18 years and over
People
50
Run by
Abramson Cancer Center at Penn Medicine
See details and how to joinNCT07048496
No phaseTaking people
Prospective Collection And Molecular Analysis Of Biospecimens And Clinical Data From Patients With Urothelial Carcinoma And Related Malignancies Of The Urinary Tract
Where
Houston
Age
18 years and over
People
50,000
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT07789119
Phase 1/2Not yet taking people in United States
Immunotherapy Plus Capivasertib for Metastatic Bladder Cancer
Where
Boston, Philadelphia, Seattle, West Haven
Age
18 years and over
People
32
Run by
VA Office of Research and Development
See details and how to joinNCT07793578
Phase 2Taking people
Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program
Where
Jacksonville
Age
18 years and over
People
50
Run by
Mayo Clinic
See details and how to joinNCT06265285
Phase 1Taking people
A Phase 1 Study of PLN-101095 in Adults With Advanced or Metastatic Solid Tumors
Where
Atlanta, Austin, East Brunswick, Fairfax, Fort Worth, Grand Rapids, Houston, Lake Success, Nashville, New Haven, Sioux Falls, St Louis, West Valley City, Wilson
Age
18 years and over
People
124 worldwide
Run by
Pliant Therapeutics, Inc.
See details and how to joinNCT06270706
Phase 3Taking people
Testing the Addition of an Anti-Cancer Drug, Gemcitabine, to Usual Treatment (BCG Alone) in People Whose Non-Muscle Invasive Bladder Cancer (NMIBC) Came Back After Prior BCG Therapy
Where
Anaconda, Avon, Baltimore, Basking Ridge, Billings, Birmingham, Boston, Bozeman, Buffalo, Burlington, Carmel, Charleston, Cheyenne, Chicago, Cody, Coeur d'Alene, Columbus, Commack, Danville, Dickson City, Fairbanks, Frederick, Gainesville, Gilbert, Great Falls, Hackensack, Harrison, Havre, Helena, Indianapolis, Irvine, Jacksonville, Kalispell, Lewisburg, Maywood, Melrose Park, Metairie, Middletown, Missoula, Montvale, New York, Oklahoma City, Orange, Peabody, Philadelphia, Phoenix, Post Falls, Reno, Richmond, Rochester, Rockledge, Sandpoint, Uniondale, Washington D.C., Wilkes-Barre
Age
18 years and over
People
330
Run by
Alliance for Clinical Trials in Oncology
See details and how to joinNCT07000084
Phase 1/2Taking people
KEYMAKER-U04 Substudy 04D: A Clinical Study of New Treatments Given With Enfortumab Vedotin and Pembrolizumab in People With Urothelial Cancer (MK-3475-04D/KEYMAKER-U04)
Where
Chicago, Cleveland, New York, Salt Lake City, San Francisco
Age
18 years and over
People
55 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT07232602 · EU 2025-522253-19-00
Phase 1Taking people
Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
Where
Austin, Baltimore, Boston, Celebration, Charlottesville, Chicago, Cleveland, Dallas, Detroit, Durham, East Brunswick, Gainesville, Hackensack, Hershey, Indianapolis, Irving, Jacksonville, Las Vegas, Littleton, Louisville, Miami, Milwaukee, Myrtle Beach, Nashville, Newark, New Haven, New York, Omaha, Palo Alto, Philadelphia, Phoenix, Pittsburgh, Plano, Plantation, Portland, Rochester, Santa Barbara, Syracuse, Tampa, Tucson, Tyler
Age
18 years and over
People
1,394 worldwide
Run by
Exelixis
See details and how to joinNCT05176483 · EU 2023-510061-10-00
No phaseTaking people
Nephroureterectomy With and Without Lymph Node Dissection for Upper Tract Urothelial Cell Carcinoma
Where
Cleveland, Gainesville, Springfield
Age
19 years and over
People
94
Run by
Case Comprehensive Cancer Center
See details and how to joinNCT06262516
Phase 2Taking people
Futibatinib in Combination With Durvalumab Prior to Cystectomy for the Treatment of Muscle-Invasive Bladder Cancer Patients Who Are Ineligible for Cisplatin-based Therapy
Where
Ann Arbor, Cleveland, Columbus
Age
18 years and over
People
24
Run by
Yuanquan Yang
See details and how to joinNCT06263153
Phase 1/2Taking people
Enfortumab Vedotin and Pembrolizumab Combined With Radiotherapy in Muscle Invasive Bladder Cancer
Where
San Francisco
Age
18 years and over
People
47
Run by
University of California, San Francisco
See details and how to joinNCT06470282
Phase 4Taking people
Enfortumab Vedotin and Pembrolizumab With Cystectomy and/or Ureterectomy for Locally Advanced or Metastatic Bladder and Upper Urothelial Tract Cancer, CAST-AI Trial
Where
Rochester
Age
18 years and over
People
75
Run by
Mayo Clinic
See details and how to joinNCT06764095