Bladder cancer trials in United States

In United States 259 Also abroad 626

259 trials · From ClinicalTrials.gov, checked 12 November 2026. Ask the study team whether a trial fits you.

Phase 3Taking people
Gemcitabine Versus Water Irrigation in Upper Tract Urothelial Carcinoma
Where
Dallas
Age
18 years to 90 years
People
132
Run by
University of Texas Southwestern Medical Center
See details and how to joinNCT04865939
Phase 1/2Taking people
A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With Advanced Solid Tumors
Where
Clovis, Hackensack, Houston, Iowa City, Los Angeles, Nashville, Newport Beach, New York, Portland
Age
18 years and over
People
1,109 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT04895709
Phase 1Taking people
A Phase I Intravesical PPM Therapy for NMIBC
Where
Boston
Age
18 years and over
People
29
Run by
VA Office of Research and Development
See details and how to joinNCT05519241
Phase 1/2Taking people
Study of 2141-V11 in People With Non-muscle Invasive Bladder Cancer That Did Not Respond to Standard Treatment
Where
Basking Ridge, Commack, Harrison, Middletown, Montvale, New York, Uniondale
Age
18 years and over
People
115
Run by
Memorial Sloan Kettering Cancer Center
See details and how to joinNCT05126472
No phaseTaking people
Tumor-informed ctDNA in Muscle-invasive Bladder Cancer for Evaluation of Residual/Recurrent Disease - the TiMBER Trial
Where
Portland
Age
18 years and over
People
100
Run by
OHSU Knight Cancer Institute
See details and how to joinNCT07726602
Phase 2Taking people
Enfortumab Vedotin With or Without Pembrolizumab in Rare Genitourinary Tumors (E-VIRTUE)
Where
Bethesda
Age
18 years to 120 years
People
68
Run by
National Cancer Institute (NCI)
See details and how to joinNCT06041503
Phase 2Taking people
Luminal Bladder Cancer Effective Response to Neoadjuvant Chemotherapy (LUMBER-NAC)
Where
New Brunswick
Age
18 years to 90 years
People
60
Run by
Rutgers, The State University of New Jersey
See details and how to joinNCT07762586
No phaseTaking people
Sample Collection for Ongoing Research and Product Evaluation Study - Non-muscle Invasive Bladder Cancer (SCORE-NMIBC)
Where
Austin
Age
18 years and over
People
400
Run by
Natera, Inc.
See details and how to joinNCT07763197
Phase 1/2Taking people
A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors
Where
Bethesda, Boston, Celebration, Columbus, Detroit, Houston, Kansas City, Madison, Miami, Nashville, Sacramento, San Antonio, Seattle
Age
18 years and over
People
366 worldwide
Run by
Marengo Therapeutics, Inc.
See details and how to joinNCT05592626 · EU 2023-505334-10-01
No phaseTaking people
Exploration of HRQOL and Urinary Outcomes Following Partial Cystectomy
Where
Rochester
Age
18 years and over
People
300
Run by
Mayo Clinic
See details and how to joinNCT06891209
Phase 1/2Taking people
LEGEND Study: EG-70 in NMIBC Patients BCG-Unresponsive and High-Risk NMIBC Incompletely Treated With BCG or BCG-Naïve
Where
Albany, Atlanta, Augusta, Austin, Baltimore, Birmingham, Boston, Buffalo, Chapel Hill, Charlottesville, Cincinnati, Dallas, Detroit, Durham, Gahanna, Grand Rapids, Greenwood, Hanover, Houston, Irvine, Jacksonville, Kansas City, La Jolla, Lakewood, Little Rock, Los Angeles, Miami, Middleburg Heights, Milwaukee, Minneapolis, Myrtle Beach, Nashville, New Brunswick, New Haven, New York, Philadelphia, Portland, Raleigh, Rochester, Salt Lake City, San Diego, Scottsdale, Syracuse, Tucson, Voorhees Township, Washington D.C.
Age
18 years and over
People
350 worldwide
Run by
enGene, Inc.
See details and how to joinNCT04752722 · EU 2024-512900-20-00
No phaseTaking people
Collecting and Studying Blood and Tissue Samples From Patients With Locally Recurrent or Metastatic Prostate or Bladder/Urothelial Cancer
Where
Seattle
Age
18 years and over
People
1,500
Run by
University of Washington
See details and how to joinNCT01050504
Phase 2Taking people
Bladder Preservation for Patients With Muscle Invasive Bladder Cancer (MIBC) With Variant Histology
Where
Los Angeles
Age
18 years and over
People
20
Run by
Leslie Ballas
See details and how to joinNCT06417190
Phase 2Taking people
Enfortumab Vedotin Plus Pembrolizumab With Selective Bladder Sparing for Treatment of Muscle-invasive Bladder Cancer
Where
Duarte, Indianapolis, New York, Philadelphia
Age
18 years and over
People
75
Run by
Matthew Galsky
See details and how to joinNCT06809140
Phase 1Taking people
IDOV-Immune for Advanced Solid Tumors
Where
Houston, San Antonio, St Louis
Age
18 years and over
People
78 worldwide
Run by
ViroMissile, Inc.
See details and how to joinNCT06910657
Phase 2Taking people
Enfortumab Vedotin Plus Pembrolizumab for the Treatment of Locally Advanced or Metastatic Bladder Cancer of Variant Histology
Where
Atlanta
Age
18 years and over
People
25
Run by
Emory University
See details and how to joinNCT05756569
Phase 2/3Taking people
Phase 2/3 Trial of Izalontamab Brengitecan vs Platinum-based Chemotherapy for Metastatic Urothelial Cancer With Disease Progression on or After Immunotherapy
Where
Abilene, Austin, Baltimore, Boston, Buffalo, Charlottesville, Cleveland, Columbus, Denver, Detroit, Dillon, Edwards, Fullerton, Gilbert, Lexington, Mayfield Heights, Miami, Murray, Nashville, New York, Norfolk, Palo Alto, Portland, Sacramento, San Francisco, Santa Rosa, Seattle, St. George, Washington D.C.
Age
18 years and over
People
470 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT07106762
No phaseNot yet taking people in United States
Analysis of Breath Volatile Organic Compounds Using Mass Spectrometry
Where
Oklahoma City
Age
18 years and over
People
2,000
Run by
University of Oklahoma
See details and how to joinNCT07732686
Phase 2Taking people
A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations
Where
Baltimore, Beverly Hills, Boston, Colombus, Columbus, Dallas, Duluth, Houston, Maumee, Miami, Morgantown, Nashville, New York, Norwalk, Omaha, Philadelphia, Providence, Rockville, Saint Joseph, San Francisco, Seattle, Summit, Temple, Toledo, Westwood, Los Angeles, Winston-Salem
Age
8 years and over
People
254 worldwide
Run by
Fore Biotherapeutics
See details and how to joinNCT05503797 · EU 2024-513578-23-00
Early phase 1Not yet taking people in United States
The Effects of Cannabis on Post Operative Recovery After Radical Cystectomy
Where
Palo Alto
Age
18 years and over
People
20
Run by
Stanford University
See details and how to joinNCT07577999
Phase 2Taking people
A Study of Disitamab Vedotin Alone or With Pembrolizumab in Urothelial Cancer That Expresses HER2
Where
Anaheim, Arcadia, Baldwin Park, Basking Ridge, Bellflower, Beverly Hills, Big Rapids, Bonita Springs, Bradenton, Burbank, Cape Coral, Carrollton, Cartersville, Chapel Hill, Charlotte, Chicago, Cleveland, Columbus, Commack, Concord, Dallas, Daytona Beach, Deerfield, Detroit, Douglasville, Duarte, Encino, Fairfax, Farmington Hills, Fleming Island, Flossmoor, Fontana, Fort Myers, Gastonia, Gilbert, Glendora, Grand Rapids, Harbor City, Harrison, Harvey, Hiram, Holland, Houston, Irvine, Knoxville, Lake Success, Lansing, Long Island City, Los Angeles, Marietta, Middletown, Milwaukee, Monroe, Montecito, Montvale, Naples, New Lenox, Newport Beach, New York, Norton Shores, N. Venice, Oklahoma City, Ontario, Orange, Orland Park, Panorama City, Pasadena, Port Charlotte, Porter Ranch, Riverside, San Diego, San Francisco, San Gabriel, San Luis Obispo, San Marcos, Santa Monica, Sarasota, Seattle, Simi Valley, Stuart, Syracuse, Tallahassee, Tampa, Temple, Templeton, Thousand Oaks, Tinley Park, Torrance, Uniondale, Valencia, Venice, Ventura, Vero Beach, Washington D.C., Wellington, Westlake Village, West Palm Beach, Woodland Hills, Worcester
Age
18 years and over
People
372 worldwide
Run by
Seagen, a wholly owned subsidiary of Pfizer
See details and how to joinNCT04879329 · EU 2022-500030-28-01
Phase 3Taking people
An Open-label Study to Investigate the Efficacy and Safety of Dato-DXd + Rilvegostomig vs SoC in Adult Participants With High-risk MIUC
Where
Albany, Boston, Chicago, Cleveland, Dallas, Falls Church, Hot Springs, Kansas City, Lincoln, Little Rock, Milwaukee, Myrtle Beach, Nashville, New York, Omaha, San Francisco, Seattle, Tacoma
Age
18 years and over
People
915 worldwide
Run by
AstraZeneca
See details and how to joinNCT07720284
Phase 1Taking people
Adaptive RADiation Therapy With Concurrent Sacituzumab Govitecan (SG) for Muscle Invasive Bladder Cancer
Where
Cleveland
Age
18 years and over
People
20
Run by
Shilpa Gupta, MD
See details and how to joinNCT05833867
Phase 2Taking people
Pembrolizumab and Enfortumab Vedotin With Pembrolizumab Prior to and After Radical Nephroureterectomy for High-Risk Upper Tract Urothelial Cancer
Where
Los Angeles
Age
18 years and over
People
21
Run by
Jonsson Comprehensive Cancer Center
See details and how to joinNCT05775471
Phase 2Taking people
Study of Neoadjuvant Enfortumab Vedotin and Pembrolizumab in Upper Tract Urothelial Cancer
Where
Ann Arbor, Philadelphia
Age
18 years and over
People
32
Run by
University of Michigan Rogel Cancer Center
See details and how to joinNCT06356155