Chronic lymphocytic leukaemia: open trials in France

49 open trials have a site in France. Registry data; only the trial team decides who can take part.

2026-525234-39-00
A Phase 1 Study of JNJ-95804306 for Relapsed or Refractory Hematological Malignancies
Trial Treatment · Phase 1 · Janssen Cilag International
Institut Paoli-Calmettes, Marseille · Hospices Civils de Lyon, Pierre-Bénite · Oncopole Claudius Regaud, Toulouse · Centre Hospitalier Régional Universitaire de Tours, Tours
Registry updated 2026-11-06
NCT05947851
A Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line (2L) + Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (MK-1026-010/BELLWAVE-010).
Trial Treatment · Phase 3 · Merck Sharp & Dohme LLC
Centre Hospitalier Universitaire Estaing (Site 2105), Clermont-Ferrand · CHD Vendee (Site 2100), La Roche-sur-Yon · Hopital Claude Huriez - CHU de Lille (Site 2107), Lille
Registry updated 2026-11-06
NCT05091424
A Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Mosunetuzumab and a Combined Regimen of Mosunetuzumab and Venetoclax in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia
Trial Treatment · Phase 1 · Hoffmann-La Roche
CHU de Clermont-Ferrand, Clermont-Ferrand · IUCT Oncopôle, Toulouse
Registry updated 2026-11-05
NCT06588478
A Study Evaluating the Efficacy and Safety of Pirtobrutinib in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Trial Treatment · Phase 2 · Loxo Oncology, Inc.
Centre Hospitalier d'Argenteuil Victor Dupouy, Argenteuil · Centre Hospitalier Universitaire de Caen - Hôpital Côte de Nacre, Caen · Centre Hospitalier du Mans, Le Mans · Groupe Hospitalier de la Region de Mulhouse et Sud Alsace Hôpital Emile Muller, Mulhouse · Centre Antoine Lacassagne, Nice · Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau, Tours
Registry updated 2026-11-04
NCT06788509
A Rollover Study for Continued Study Treatment and Ongoing Safety Monitoring
Trial Treatment · Phase 1 · Janssen Research & Development, LLC
Centre Hospitalier Universitaire de Lille, Lille · Institut Paoli-Calmettes, Marseille · Centre Hospitalier Universitaire de Nantes, Nantes · Institut Curie, Paris · Oncopole Claudius Regaud, Toulouse · Institut Gustave Roussy, Villejuif
Registry updated 2026-11-04
NCT07218341
A Study of Pirtobrutinib (LY3527727) in Participants With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Trial Treatment · Phase 4 · Eli Lilly and Company
Centre Henri Becquerel, Rouen
Registry updated 2026-11-04
NCT06299540
Benefits of Individual Physical Activity Intervention on Health-related Quality of Life in Participants With Chronic Lymphocytic Leukemia
Research · Janssen Cilag S.A.S.
Institut Universitaire du Cancer Toulouse - Oncopole, Toulouse
Registry updated 2026-11-03
NCT07221500
A Study of NX-5948 in Adults With CLL/SLL Previously Treated With a Bruton's Tyrosine Kinase Inhibitor and a B-cell Lymphoma-2 Inhibitor (DAYBreak CLL-201)
Trial Treatment · Phase 2 · Nurix Therapeutics, Inc.
CHU de Nantes, Nantes
Registry updated 2026-11-03
NCT06564038
A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies
Trial Treatment · Phase 1/2 · AstraZeneca
University Hospital Of Clermont-Ferrand, Clermont-Ferrand · Centre Hospitalier Universitaire De Montpellier, Montpellier Cedex 5 · Hopital Saint Louis, Paris · Institut Curie, Saint-Cloud · Institut Gustave Roussy, Villejuif
Registry updated 2026-10-28
NCT04728893
Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)
Trial Treatment · Phase 2 · Merck Sharp & Dohme LLC
Centre Hospitalier de Versailles (Site 0809), Le Chesnay · Institut Paoli-Calmettes (Site 0803), Marseille · Centre Hospitalier Universitaire de Nice - Hôpital l'Archet (Site 0810), Nice · Hopital Saint Louis (Site 0805), Paris · Centre Hospitalier Lyon-Sud (Site 0804), Pierre-Bénite
Registry updated 2026-10-27
NCT06548152
AQUALIS:QoL of CLL Patients Treated With Acalabrutinib in France, Retrospective Study Based on Data From PLATON Database
Research · AstraZeneca
Saint-Affrique
Registry updated 2026-10-27
NCT06697184
A Study to Investigate the Safety of Novel Dose Ramp-up Schedule(s) When Initiating Sonrotoclax in Participants Treated for Blood Cancers.
Trial Treatment · Phase 1/2 · BeOne Medicines
Centre Hospitalier Universitaire de Dijon, Dijon · Centre Hospitalier Universitaire De Montpellier, Montpellier Cedex 5 · Oncopole Claudius Regaud, Toulouse Cedex 9
Registry updated 2026-10-26
NCT06943872
A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)
Trial Treatment · Phase 3 · BeOne Medicines
University Hospital Of Clermont-Ferrand, Clermont-Ferrand · Centre Hospitalier Universitaire de Nantes, Nantes · Assistance Publique Hopitaux De Paris, Paris Cedex 13 · Hospices Civils de Lyon, Pierre-Bénite · Centre Hospitalier Universitaire Reims, Reims Cedex · Centre Hospitalier Universitaire De Rennes, Rennes Cedex 9 · Centre Henri Becquerel, Rouen · Centre Hospitalier Universitaire De Toulouse, Toulouse Cedex 9 · CHRU De Nancy, Vandoeuvre Les Nancy
Registry updated 2026-10-23
NCT07648264
Single-arm Study of IgPro20 in Adults With Secondary Immune Deficiencies Due to Hematologic Malignancies Treated With B-cell Targeting Chimeric Antigen Receptor T-cell and T-cell Redirecting Therapies
Trial Treatment · Phase 3 · CSL Behring
CHU Angers - Hôpital Hôtel Dieu#, Angers · Centre Hospitalier Départemental Les Oudairies, La Roche-sur-Yon · CHU de Nantes - Hôtel Dieu, Nantes · CHU Rennes - Hopital Pontchaillou, Rennes · Centre Henri Becquerel, Rouen
Registry updated 2026-10-14
NCT07691047
Reassessment of the Risk of Hemolytic Syndrome in Patients With Chronic Lymphocytic Leukemia Treated With a Regimen Containing Venetoclax
Trial Treatment · Private Hospital of Confluent, France
Clinique de l'Europe, Amiens · Hôpital Privé du Confluent, Nantes
Registry updated 2026-10-13
NCT03934372
Safety and Efficacy of Ponatinib for Treatment of Pediatric Recurrent or Refractory Leukemias, Lymphomas or Solid Tumors
Trial Treatment · Phase 1/2 · Incyte Biosciences International Sàrl
Armand Trousseau Hospital, Paris · Hopital Robert Debre, Paris · Centre Hospitalier Universitaire de Poitiers, Poitiers · Chu de Rennes - Hospital Sud, Rennes
Registry updated 2026-10-09
NCT05006716
A Dose-Escalation and Expansion Study of Tacabrutideg (BGB-16673) in Participants With B-Cell Malignancies
Trial Treatment · Phase 1/2 · BeOne Medicines
Centre de Lutte Contre Le Cancer Institut Bergonie, Bordeaux · Hopital Estaing, ClermontFerrand · CHU Henri Mondor, Créteil · Hopital Claude Huriez - Chu Lille, Lille · Centre Leon Berard, Lyon · Institut Paoli-Calmettes, Marseille · CHU Montpellier - Hôpital Saint Eloi, Montpellier · Hôpital de la Pitié-Salpêtrière, Paris · Centre Henri Becquerel, Rouen
Registry updated 2026-10-05
2023-510294-34-00
A phase 3 multicenter, randomised, prospective, open-label trial of fixed-duration (12 cycles) venetoclax/ obinutuzumab vs. fixed-duration (15 cycles) venetoclax/ pirtobrutinib vs. MRD-guided venetoclax/ pirtobrutinib in patients with previously untreated chronic lymphocytic leukaemia (CLL)/ small lymphocytic lymphoma (SLL) aiming to establish measurement of individual residual disease for adjustment of treatment duration to improve outcomes (CLL18/ MOIRAI)
Trial Treatment · Phase 3 · University Of Cologne
Centre Hospitalier Universitaire D'Angers, Angers · University Hospital Of Clermont-Ferrand, Clermont-Ferrand · Centre Hospitalier Universitaire Grenoble Alpes, Grenoble Cedex 9 · Centre Hospitalier Universitaire De Lille, Lille Cedex · Groupement Des Hopitaux De L'Institut Catholique De Lille, Lille Cedex · Centre Leon Berard, Lyon · Institut Paoli-Calmettes, Marseille · Centre Hospitalier Universitaire De Montpellier, Montpellier Cedex 5 · Centre Hospitalier Universitaire de Nantes, Nantes · Assistance Publique Hopitaux de Paris, Paris · Hopitaux Universitaires Pitie Salpetriere, Paris · University Hospital Of Bordeaux, Pessac Cedex · Hospices Civils de Lyon, Pierre-Bénite · Centre Hospitalier Universitaire de Poitiers, Poitiers · Centre Hospitalier Universitaire Reims, Reims Cedex · Centre Hospitalier Universitaire de Rennes, Rennes · Centre Henri Becquerel, Rouen Cedex · Oncopole Claudius Regaud, Toulouse Cedex 9 · Centre Hospitalier Regional Universitaire De Tours, Tours Cedex 9 · CHRU De Nancy, Vandoeuvre Les Nancy
Registry updated 2026-10-01
2024-512503-39-00
Registry and clinical trial comparing standard intensity and reduced intensity treatment in patients with AML or CLL who do not have residual disease.
Trial Treatment · Phase 4 · Medizinische Hochschule Hannover
CHU Angers, ANGERS Cedex 09 · Centre Hospitalier Universitaire Grenoble Alpes, Grenoble Cedex 09 · Centre Hospitalier Universitaire de Nantes, Nantes · Centre Hospitalier Universitaire de Bordeaux, Pessac · Centre Hospitalier Universitaire De Rennes, Rennes Cedex 9 · Oncopole Claudius Regaud, Toulouse Cedex 9
Registry updated 2026-10-01
NCT07582432
A Clinical Trial to Evaluate Efficacy, Safety, and Pharmacokinetics of Gamunex in Participants With Secondary Antibody Deficiency Associated With Chronic Lymphocytic Leukemia, Multiple Myeloma, or Non-Hodgkin Lymphoma
Trial Treatment · Phase 3 · Grifols Biologicals, LLC
Hôpital Cavale Blanche CHU de Brest, Brest · L'Hopital Prive Du Confluent, Nantes Cedex 2 · CHU de Tours -Hôpital Bretonneau, Tours
Registry updated 2026-10-01
NCT06542250
A Study to Evaluate Safety, PK, PD and Efficacy of AZD5492, a T Cell-engaging Antibody Targeting CD20 in Subjects With R/R B-Cell Malignancies.
Trial Treatment · Phase 1/2 · AstraZeneca
Pessac · Villejuif
Registry updated 2026-09-30
NCT06973187
A Study to Evaluate the Safety and Efficacy of Tacabrutideg (BGB-16673) Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Trial Treatment · Phase 3 · BeOne Medicines
Institut Bergonie, Bordeaux · University Hospital Of Clermont-Ferrand, Clermont-Ferrand · Centre Hospitalier Universitaire de Nantes, Nantes · Hopital Saint Louis, Paris · Centre Henri Becquerel, Rouen · Centre Hospitalier Universitaire De Toulouse, Toulouse Cedex 9 · Centre Hospitalier Regional Universitaire De Tours, Tours Cedex 9 · CHRU De Nancy, Vandoeuvre Les Nancy Cedex
Registry updated 2026-09-28
NCT07277231
A Study to Investigate Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Acalabrutinib in Adults With Previously Untreated Chronic Lymphocytic Leukemia
Trial Treatment · Phase 3 · BeOne Medicines
Institut Bergonie, Bordeaux · University Hospital Of Clermont-Ferrand, Clermont-Ferrand · Centre Hospitalier Le Mans, Le Mans Cedex 9 · Centre Hospitalier Universitaire De Lille, Lille Cedex · Centre Leon Berard, Lyon · Centre Hospitalier Universitaire De Montpellier, Montpellier Cedex 5 · Centre Hospitalier Universitaire De Toulouse, Toulouse Cedex 9
Registry updated 2026-09-28
2026-525763-40-00
FILOCLL017 - NEVOTAL : Nemtabrutinib in addition to Venetoclax-Obinutuzumab in chronic lymphocytic leukemia (CLL) / small lymphocytic leukemia (SLL) patients with TP53 ALterations
Trial Treatment · Phase 2 · French Innovative Leukemia Organization (F.I.L.O.).
Centre Hospitalier Universitaire Amiens Picardie, Amiens Cedex 1 · Centre Hospitalier Victor Dupouy, Argenteuil Cedex · Centre Hospitalier d'Avignon, Avignon · Centre Hospitalier de la Cote Basque, Bayonne · CHU Besançon, Besançon · Institut Bergonie, Bordeaux · University Hospital Of Clermont-Ferrand, Clermont-Ferrand · Centre Hospitalier Sud Francilien, Corbeil-Essonnes · CHU Henri Mondor, Créteil Cedex · Centre Hospitalier Annecy Genevois, Epagny Metz-tessy · Centre Hospitalier Universitaire Grenoble Alpes, Grenoble Cedex 9 · Centre Hospitalier De Versailles, Le Chesnay Rocquencourt · Chorale Du Centre Hospitalier De Lens, Lens · Centre Hospitalier De Libourne Robert Boulin, Libourne · Groupement Des Hopitaux De L'Institut Catholique De Lille, Lille Cedex · Centre Hospitalier Et Universitaire de Limoges, Limoges · Centre De Recherche En Cancerologie De Lyon, Lyon · Groupe Hospitalier de la Région de Mulhouse et Sud Alsace, Mulhouse · Centre Hospitalier Universitaire De Nimes, Nimes Cedex 9 · Centre Hospitalier Universitaire d'Orléans, ORLEANS · APHP - Hôpital Universitaire Pitié-Salpêtrière, PARIS · Centre Hospitalier De Perpignan, Perpignan Cedex · Centre Hospitalier Universitaire Reims, Reims Cedex · Centre Henri Becquerel, Rouen · Centre Hospitalier De Saint-Brieuc, Saint-Brieuc · Centre Hospitalier Universitaire De Toulouse, Toulouse Cedex 9 · Centre Hospitalier Régional Universitaire de Tours, Tours · Centre Hospitalier Valence, Valence · CHRU De Nancy, Vandoeuvre Les Nancy · Centre Hospitalier Bretagne Atlantique, Vannes
Registry updated 2026-09-25
NCT04935684
Faecal Microbiota Transplantation After Allogeneic Stem Cell Transplantation
Trial Treatment · Phase 2 · University Hospital, Clermont-Ferrand
Service d'Hématologie Clinique et Thérapie Cellulaire CHU Amiens Picardie - Site Sud, Amiens · Service Maladies du sang CHU Angers, Angers · Hématologie clinique CHU Besançon, Besançon · Plateforme d'Investigation Clinique / Centre d'Investigation Clinique - Inserm 1405, CHU Gabriel Montpied Clermont-Ferrand, Clermont-Ferrand · Service de thérapie Cellulaire et d'Hématologie Clinique Adulte CHU Estaing - Clermont-Ferrand, Clermont-Ferrand · Service hématologie CHU Grenoble, Grenoble · Service des Maladies du sang Hôpital HURIEZ, CHRU de Lille, Lille · Service de thérapie cellulaire et l'hématologie clinique adulte CHU Limoges, Limoges · Service d'Hématologie Centre Hospitalier Lyon Sud, Lyon · Service d'Hématologie et de Médecine interne Hôpital Brabois CHRU Nancy, Nancy · Service d'Hématologie Clinique CHU Nantes, Nantes · Service d'hématologie clinique, département de greffe de moelle CHU Nice, Nice · Service d'hématologie greffe Hôpital St Louis, Paris · Service d'Hématologie clinique Hôpital Pitié-Salpêtrière, Paris · Service d'Hématologie Adultes Hôpital Necker, Paris · Hématologie clinique et thérapie cellulaire Hôpital Haut-Lévèque, Pessac · Service d'hématologie greffe Hôpital St Louis, Poitiers · Département d'hématologie CAC Rouen, Rouen · Hématologie clinique Institut de Cancérologie de la Loire, Saint-Etienne · IUC T - Oncopôle, Toulouse
Registry updated 2026-09-21

All Chronic lymphocytic leukaemia trials and the map

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