Chronic lymphocytic leukaemia trials in United States

In United States 186 Also abroad 309

186 trials · From ClinicalTrials.gov, checked 14 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
A Registry for People With T-cell Lymphoma
Where
Atlanta, Aurora, Basking Ridge, Boston, Chicago, Columbus, Commack, Duarte, Harrison, Houston, Miami, Middletown, New Haven, New York, Omaha, Philadelphia, Rochester, San Diego, San Francisco, Stanford, St Louis, Tampa, Uniondale
People
1,000
Run by
Memorial Sloan Kettering Cancer Center
See details and how to joinNCT05978141
Phase 1Taking people
HA-1 T TCR T Cell Immunotherapy for the Treatment of Patients With Relapsed or Refractory Acute Leukemia After Donor Stem Cell Transplant
Where
Seattle
Age
Up to 80 years
People
24
Run by
Fred Hutchinson Cancer Center
See details and how to joinNCT03326921
No phaseTaking people
MCW Alpha/Beta T-Cell and B-Cell Depletion With Targeted ATG Dosing
Where
Milwaukee
Age
0 years to 25 years
People
40
Run by
Medical College of Wisconsin
See details and how to joinNCT05794880
No phaseTaking people
Study of MGUS, Smoldering Myeloma, Early MDS and CLL to Assess Molecular Events of Progression and Clinical Outcome
Where
Boston, Brighton, Kalamazoo, Londonderry, Methuen, Milford, Weymouth
Age
18 years and over
People
10,000
Run by
Dana-Farber Cancer Institute
See details and how to joinNCT02269592
Phase 1Taking people
Study of Oral Administration of LP-118 in Patients With Relapsed or Refractory CLL, SLL, MDS, MDS/MPN, AML, CMML-2, MPN-BP, ALL, MF, NHL, RT, MM or T-PLL.
Where
Boston, Chapel Hill, Chicago, Cincinnati, Columbus, Houston, Salt Lake City
Age
13 years and over
People
100
Run by
Newave Pharmaceutical Inc
See details and how to joinNCT04771572
Phase 2Taking people
Time-limited Triplet Combination of Pirtobrutinib, Venetoclax, and Obinutuzumab for Patients With Treatment-naïve Chronic Lymphocytic Leukemia (CLL) or Richter Transformation (RT)
Where
Houston
Age
18 years and over
People
60
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT05536349
Phase 1Taking people
Zanubrutinib in Combination With Sonrotoclax for the Treatment of Underrepresented Ethnic and Racial Minorities With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma
Where
Duarte
Age
18 years and over
People
37
Run by
City of Hope Medical Center
See details and how to joinNCT06859008
Phase 1/2Taking people
The OPAL Study: AVM0703 for Treatment of Lymphoid Malignancies
Where
Canton, Chicago, Dallas, Duarte, Los Angeles, Louisville, Memphis, Omaha, Weeki Wachee, Whittier
Age
12 years to 95 years
People
144
Run by
AVM Biotechnology Inc
See details and how to joinNCT04329728
No phaseTaking people
The Prospective Collection, Storage and Reporting of Data on Patients Undergoing Hematopoietic Stem Cell Transplantation Utilizing a Standard Preparative Regimen
Where
Winston-Salem
Age
18 years to 120 years
People
2,000
Run by
Wake Forest University Health Sciences
See details and how to joinNCT01890486
Phase 2Taking people
Pneumococcal Pneumonia Vaccine Series (PCV20 and PPSV23) in Patients With Chronic Lymphocytic Leukemia Associated Immunodeficiency, PROTECT CLL Trial
Where
Salt Lake City
Age
18 years and over
People
61
Run by
University of Utah
See details and how to joinNCT05183854
No phaseTaking people
The Effects of Exercise on Immune Phenotype of Indolent Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia Patients
Where
Rochester, Scottsdale
Age
18 years to 80 years
People
70
Run by
Mayo Clinic
See details and how to joinNCT05876923
Phase 3Taking people
A Study to Evaluate the Risk of Tumor Lysis Syndrome (TLS) in Adult Participants Receiving Oral Venetoclax in Combination With Intravenously Infused Obinutuzumab or Oral Acalabrutinib for Previously Untreated Chronic Lymphocytic Leukemia (CLL)
Where
Aurora, Austin, Bethesda, Charlotte, Cleveland, Clovis, Dallas, Des Moines, Detroit, Dyer, Eugene, Fairfax, Gainesville, Jacksonville, Kansas City, Los Angeles, Morgantown, New Haven, New York, Olympia, Orange City, Providence, Shreveport, Silver Spring, Springfield, St. Petersburg, Tacoma, Tucson, Tulsa, Winston-Salem, Worcester
Age
18 years and over
People
170 worldwide
Run by
AbbVie
See details and how to joinNCT06428019 · EU 2024-512147-23-00
No phaseTaking people
Predictors of Health-Related QOL in Adults With CLL or Small Lymphocytic Lymphoma
Where
Tampa
Age
18 years and over
People
100
Run by
H. Lee Moffitt Cancer Center and Research Institute
See details and how to joinNCT07030400
No phaseTaking people
Hematopoiesis in MBL and CLL Versus Healthy Age-Matched Control Subjects
Where
Rochester
Age
40 years and over
People
50
Run by
Mayo Clinic
See details and how to joinNCT06536452
No phaseTaking people
Survivors Uniting for Remote Guided Exercise
Where
Fort Collins
Age
18 years and over
People
300
Run by
Colorado State University
See details and how to joinNCT07290309
Phase 1/2Taking people
Metabolically Fit CD19 CAR T-cell Therapy With CD34 Selection in Patients With CD19+ Relapsed/Refractory NHL, CLL/SLL
Where
Charleston
Age
18 years and over
People
27
Run by
Medical University of South Carolina
See details and how to joinNCT05702853
Phase 1Taking people
Expanded/Activated Gamma Delta T-cell Infusion Following Hematopoietic Stem Cell Transplantation and Post-transplant Cyclophosphamide
Where
Columbus, Westwood
Age
18 years to 65 years
People
38
Run by
University of Kansas Medical Center
See details and how to joinNCT03533816
Phase 1Taking people
A Study of NX-2127 in Adults With Relapsed/Refractory B-cell Malignancies
Where
Bethesda, Chicago, Cincinnati, Columbus, Dallas, Denver, Duarte, Houston, Miami Beach, Nashville, New York, Orange, Salt Lake City, San Francisco, Sarasota, Seattle
Age
18 years and over
People
248
Run by
Nurix Therapeutics, Inc.
See details and how to joinNCT04830137
Phase 2Taking people
A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation
Where
Birmingham, Boston, Chapel Hill, Charlottesville, Detroit, Duarte, Houston, Miami, New York, Palo Alto, Portland, Seattle, Westwood
Age
18 years to 66 years
People
358
Run by
Center for International Blood and Marrow Transplant Research
See details and how to joinNCT06859424
Phase 2Taking people
Venetoclax and Obinutuzumab Followed by Epcoritamab for the Treatment of Untreated Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma, LonGEVity Trial
Where
Duarte, Irvine, Long Beach, Miami, Milwaukee, Newnan, New York
Age
18 years and over
People
33
Run by
City of Hope Medical Center
See details and how to joinNCT07218510
Phase 2Taking people
Zanubrutinib and Lisocabtagene Maraleucel for the Treatment of Richter's Syndrome
Where
Columbus, New York, Salt Lake City
Age
18 years and over
People
24
Run by
Aseel Alsouqi
See details and how to joinNCT05873712
Phase 4Taking people
A Master Protocol to Evaluate the Long-Term Safety of (LY3527727) Pirtobrutinib
Where
Atlanta, Boston, Chicago, Columbus, Durham, Houston, Ithaca, Jacksonville, Lake Success, Miami, Milwaukee, Nashville, New York, Omaha, Philadelphia, Rochester, Sarasota, Seattle
Age
18 years and over
People
787 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT06876649
Phase 4Taking people
A Study of (LY3527727) Pirtobrutinib in Participants With Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Non-Hodgkin Lymphoma
Where
Atlanta, Boston, Chicago, Columbus, Durham, Houston, Ithaca, Lake Success, Miami, Milwaukee, Nashville, New York, Omaha, Philadelphia, Rochester, Sarasota, Seattle
Age
18 years and over
People
279 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT06876662
No phaseTaking people
Evaluation of Hypertension Management and Cardiovascular Adverse Event Prevention in Patients With B-cell Malignancies Undergoing Treatment With Bruton Tyrosine Kinase Inhibitors, the HALT Study
Where
Rochester
People
100
Run by
Mayo Clinic
See details and how to joinNCT06151730
Phase 1/2Taking people
CAR-20/19-T Cells in Patients With Relapsed Refractory B Cell Malignancies
Where
Milwaukee
Age
18 years to 80 years
People
100
Run by
Medical College of Wisconsin
See details and how to joinNCT04186520