Chronic lymphocytic leukaemia trials in United States

In United States 186 Also abroad 309

186 trials · From ClinicalTrials.gov, checked 14 November 2026. Ask the study team whether a trial fits you.

Phase 2Taking people
Acalabrutinib in Combination With Venetoclax or Obinutuzumab for the Treatment of Treatment-naive Chronic Lymphocytic Leukemia
Where
Columbus
Age
18 years and over
People
52
Run by
Ohio State University Comprehensive Cancer Center
See details and how to joinNCT05336812
Phase 2Taking people
Pirtobrutinib (LOXO-305) and Venetoclax for the Treatment of Patients With CLL or SLL Resistant to Covalent BTKi
Where
Columbus
Age
18 years and over
People
30
Run by
Kerry Rogers
See details and how to joinNCT06466122
Phase 1Taking people
Study of SGR-1505 in Mature B-Cell Neoplasms
Where
Boston, Buffalo, Canton, Columbus, Dallas, Durham, Gilbert, Hackensack, Milwaukee, Newark, New York, Pompano Beach, Portland, Providence, Seattle, The Bronx
Age
18 years and over
People
98 worldwide
Run by
Schrödinger, Inc.
See details and how to joinNCT05544019 · EU 2023-505204-34-00
Phase 1Taking people
B-Cell Activating Factor Receptor (BAFFR)-Based Chimeric Antigen Receptor T-Cells With Fludarabine and Cyclophosphamide Lymphodepletion for the Treatment of Relapsed or Refractory B-cell Hematologic Malignancies
Where
Jacksonville
Age
18 years and over
People
27
Run by
Mayo Clinic
See details and how to joinNCT06191887
Phase 1/2Taking people
Roginolisib (IOA-244) With Venetoclax and Rituximab for Refractory/Relapsed Chronic Lymphocytic Leukemia (CLL)
Where
Boston
Age
18 years and over
People
64
Run by
Jennifer R. Brown, MD, PhD
See details and how to joinNCT06644183
Phase 2Taking people
Study to Assess Change in Disease Activity and Adverse Events of Oral Venetoclax With Intravenous (IV) Obinutuzumab in Adult Participants With Recurring Chronic Lymphocytic Leukemia (CLL)
Where
Atlanta, Boston, Chapel Hill, Charlotte, Columbus, Des Moines, Detroit, Duluth, Florham Park, Hackensack, Hattiesburg, La Jolla, Madison, Philadelphia, Winston-Salem
Age
18 years and over
People
75 worldwide
Run by
AbbVie
See details and how to joinNCT04895436 · EU 2023-504599-10-00
No phaseTaking people
Transgene Assay Testing Service of Tumor Samples From Patients Who Received a Bristol-Myers Squibb Manufactured Gene Modified Cell Therapy and Have a Qualifying Second Primary Malignancy
Where
Dallas, Madison, Portland, Salt Lake City
People
50 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT06357754
Phase 2Taking people
Fixed Duration Pirtobrutinib and Obinutuzumab in Chronic Lymphocytic Leukemia
Where
Boston, Scarborough
Age
18 years and over
People
60
Run by
Inhye Ahn
See details and how to joinNCT06333262
Phase 1Taking people
Study of Kappa Chimeric Antigen Receptor (CAR) T Lymphocytes Co-Expressing the Kappa and CD28 CARs for Relapsed/Refractory Kappa+ Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma.
Where
Chapel Hill
Age
18 years and over
People
20
Run by
UNC Lineberger Comprehensive Cancer Center
See details and how to joinNCT04223765
Phase 2Taking people
Anti-pneumococcal Vaccine Strategy in Patients With Chronic Lymphocytic Leukemia
Where
Columbus
Age
18 years and over
People
80
Run by
Seema Bhat
See details and how to joinNCT05417165
Phase 2Taking people
Intermittent Versus Continuous Venetoclax With Acalabrutinib for CLL/SLL
Where
Cincinnati
Age
18 years and over
People
62
Run by
Zulfa Omer
See details and how to joinNCT07014917
Phase 2Taking people
Study of Epcoritamab as a Consolidation Therapy in CLL/SLL
Where
Cincinnati
Age
18 years and over
People
22
Run by
Zulfa Omer
See details and how to joinNCT07108998
Phase 2Taking people
Acalabrutinib for the Treatment of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Where
Columbus
Age
18 years and over
People
61
Run by
Seema Bhat
See details and how to joinNCT06757647
Phase 1/2Taking people
Mosunetuzumab for CLL MRD Clearance
Where
Boston
Age
18 years and over
People
40
Run by
Inhye Ahn
See details and how to joinNCT07052695
Phase 1Taking people
AS-1763 in Patients With Previously Treated CLL/SLL or Non-Hodgkin Lymphoma
Where
Baltimore, Chicago, Durham, Fort Wayne, Houston, Maumee, Miami Beach, Milwaukee, Orange, Tampa, Westbury, Worcester
Age
18 years and over
People
120
Run by
Carna Biosciences, Inc.
See details and how to joinNCT05602363
Phase 2Taking people
Zanubrutinib and Venetoclax in CLL (ZANU-VEN)
Where
Boston, Scarborough, South Weymouth
Age
18 years and over
People
45
Run by
Dana-Farber Cancer Institute
See details and how to joinNCT05168930
No phaseTaking people
In Vivo Metabolic Profiling of CLL (Chronic Lymphocytic Leukemia)
Where
Madison
Age
18 years and over
People
16
Run by
University of Wisconsin, Madison
See details and how to joinNCT04785989
No phaseTaking people
Fitness and Lung Function Among Survivors of Heart Transplant, Leukemia and Infant BPD Through Exercise
Where
Minneapolis
Age
8 years to 25 years
People
90
Run by
Masonic Cancer Center, University of Minnesota
See details and how to joinNCT05025774
Phase 1/2Taking people
A Safety and Efficacy Study Evaluating CTX112 in Subjects With Relapsed or Refractory B-Cell Malignancies
Where
Salt Lake City, San Antonio, St Louis, Westwood
Age
18 years and over
People
120 worldwide
Run by
CRISPR Therapeutics AG
See details and how to joinNCT05643742
No phaseTaking people
Long-term Follow-up Study of Patients Receiving CAR-T Cells
Where
Milwaukee
Age
18 years to 80 years
People
500
Run by
Medical College of Wisconsin
See details and how to joinNCT03375619
Phase 1Taking people
Phase 1 Study of BAFF CAR-T Cells (LMY-920) for Treatment of Relapsed or Refractory Chronic Lymphocytic Leukemia / Small Lymphocytic Lymphoma
Where
Cleveland
Age
18 years and over
People
18
Run by
Paolo Caimi, MD
See details and how to joinNCT06916767
Phase 1Taking people
Tafasitamab, Acalabrutinib, and Obinutuzumab for the Treatment of Previously Untreated Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma
Where
Portland
Age
18 years and over
People
27
Run by
OHSU Knight Cancer Institute
See details and how to joinNCT05943496
Phase 1Taking people
Study of HQP1351 in Subjects With Refractory CML and Ph+ ALL
Where
Atlanta, Augusta, Baltimore, Birmingham, Cleveland, Duarte, Houston, Seattle
Age
18 years and over
People
242 worldwide
Run by
Ascentage Pharma Group Inc.
See details and how to joinNCT04260022
Phase 1Taking people
ABL001 + Dasatinib + Prednisone + Blinatumomab in BCR-ABL+ B-ALL or CML
Where
Boston, Buffalo, Chicago
Age
18 years and over
People
40
Run by
Marlise Luskin, MD
See details and how to joinNCT03595917
Phase 2Taking people
Two Step Haplo With Radiation Conditioning
Where
Philadephia
Age
18 years and over
People
63
Run by
Thomas Jefferson University
See details and how to joinNCT05031897