Chronic lymphocytic leukaemia trials in United States

In United States 185 Also abroad 308

185 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 2Taking people
Sonrotoclax, Rituximab, and Zanubrutinib in Treating Participants With Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, and Mantle Cell Lymphoma
Where
Seattle
Age
18 years and over
People
30
Run by
Fred Hutchinson Cancer Center
See details and how to joinNCT06839053
No phaseTaking people
Collection of Human Samples to Study Hairy Cell and Other Leukemias, and to Develop Recombinant Immunotoxins for Cancer Treatment
Where
Bethesda
Age
18 years and over
People
1,263
Run by
National Cancer Institute (NCI)
See details and how to joinNCT01087333
No phaseTaking people
Cancer Experience Registry (CER) for Cancer Patients and Caregivers
Where
Washington D.C.
Age
18 years and over
People
15,000
Run by
Cancer Support Community, Research and Training Institute, Philadelphia
See details and how to joinNCT02333604
Phase 1Taking people
Testing the Addition of an Anti-cancer Drug, Lenalidomide, to the Usual Combination Chemotherapy Treatment ("EPOCH") for Adult T-Cell Leukemia-Lymphoma (ATLL)
Where
Atlanta, Basking Ridge, City of Saint Peters, Columbus, Commack, Creve Coeur, Harrison, Middletown, Mineola, Montvale, New York, Richmond, St Louis, Uniondale
Age
18 years and over
People
30
Run by
National Cancer Institute (NCI)
See details and how to joinNCT04301076
No phaseTaking people
Observational Study of Cardiac Arrhythmias During Treatment With BTK Inhibitors or Venetoclax
Where
Bethesda
Age
18 years to 110 years
People
135
Run by
National Heart, Lung, and Blood Institute (NHLBI)
See details and how to joinNCT05724121
No phaseTaking people
Pharmacokinetic Study of Venetoclax Tablets Crushed and Dissolved Into a Solution
Where
Atlanta, Aurora, Cincinnati, Houston, Milwaukee, Philadelphia
Age
0 years to 38 years
People
30
Run by
Children's Hospital Medical Center, Cincinnati
See details and how to joinNCT06131801
Phase 2Taking people
Nemtabrutinib and Lisocabtagene Maraleucel for the Treatment of Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Where
Seattle
Age
18 years and over
People
20
Run by
Fred Hutchinson Cancer Center
See details and how to joinNCT07194980
Phase 1Taking people
Prophylactic DLI-X for Leukemia Relapse After HCT
Where
Tucson
Age
Up to 65 years
People
180
Run by
University of Arizona
See details and how to joinNCT07254793
Phase 2Taking people
A Phase 2 Trial Of The Bruton Tyrosine Kinase Degrader BGB-16673 In Combination With BCL-2 Inhibitor Sonrotoclax For Patients With Treatment-Naive Chronic Lymphocytic Leukemia (CLL)
Where
Houston
Age
18 years and over
People
40
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT07508995
No phaseTaking people
Tissue, Blood, and Body Fluid Sample Collection From Patients With Hematologic Cancer
Where
Chapel Hill
Age
18 years to 120 years
People
15,000
Run by
UNC Lineberger Comprehensive Cancer Center
See details and how to joinNCT01137643
Phase 1/2Taking people
A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies
Where
Boston, Charlotte, Columbus, Hackensack, Houston, New Brunswick, New York, Philadelphia, Pittsburgh, Portland, Providence, Winston-Salem
Age
18 years and over
People
408 worldwide
Run by
AstraZeneca
See details and how to joinNCT06564038 · EU 2024-515034-33-00
No phaseTaking people
A Multi-site Study to Evaluate the Persistence of Protective Immunity to Routine Childhood Vaccinations in Participants With B-ALL/Ly Who Have Received Blinatumomab
Where
Little Rock, Springdale
Age
1 year to 23 years
People
300
Run by
Arkansas Children's Hospital Research Institute
See details and how to joinNCT07422337
Phase 2Taking people
Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)
Where
Dallas, Denver, East Brunswick, Fargo, Hackensack, La Jolla, Louisville, Rochester, Spokane, Springdale, Torrance
Age
18 years and over
People
490 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT04728893 · EU 2023-504931-42-00
Phase 2Taking people
Acalabrutinib With or Without Obinutuzumab in Treating Patients With Early-Stage Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Where
Jacksonville, Rochester, Scottsdale
Age
18 years and over
People
120
Run by
Mayo Clinic
See details and how to joinNCT03516617
Phase 1/2Taking people
CD19/CD22 Bicistronic Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults With Recurrent or Refractory B Cell Malignancies
Where
Bethesda
Age
3 years to 39 years
People
130
Run by
National Cancer Institute (NCI)
See details and how to joinNCT05442515
Phase 2Taking people
Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in Treating Patients With High-Risk Hematologic Diseases
Where
Seattle
Age
6 months to 65 years
People
54
Run by
Fred Hutchinson Cancer Center
See details and how to joinNCT06013423
Phase 1/2Taking people
Gene Therapy for CD19-Positive Hematologic Malignancies (SENTRY-CD19)
Where
Chapel Hill, Columbus, Denver, Duarte, Houston, Jacksonville, Los Angeles, Nashville, Portland, Rochester, Valhalla
Age
13 years to 90 years
People
32
Run by
Vironexis Biotherapeutics Inc.
See details and how to joinNCT06533579
Phase 1/2Taking people
A Study to Investigate the Safety of Novel Dose Ramp-up Schedule(s) When Initiating Sonrotoclax in Participants Treated for Blood Cancers.
Where
Boston, Fort Wayne, Seattle, St Louis, Tampa, Westwood
Age
18 years and over
People
258 worldwide
Run by
BeOne Medicines
See details and how to joinNCT06697184 · EU 2024-518829-15-00
Phase 2Taking people
Acalabrutinib in Combination With Venetoclax for the Treatment of Refractory or Recurrent Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma, The AVENUE-2 Trial
Where
Seattle
Age
18 years and over
People
20
Run by
Fred Hutchinson Cancer Center
See details and how to joinNCT04941716
Phase 2Taking people
CMV-MVA Triplex Vaccination in HLA-Matched Related Stem Cell Donors for the Prevention of CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplant
Where
Atlanta, Boston, Duarte
Age
18 years to 75 years
People
216
Run by
City of Hope Medical Center
See details and how to joinNCT06059391
Phase 3Taking people
A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)
Where
Aurora, Baltimore, Baton Rouge, Boston, Chapel Hill, Charlotte, Chattanooga, Chicago, Cincinnati, Dallas, Eugene, Grand Rapids, Hershey, Iowa City, Laguna Hills, Louisville, Nashville, New Haven, New York, Niles, Norwich, Omaha, Orange, Palo Alto, Philadelphia, Pittsburgh, Rochester, San Antonio, San Diego, Santa Fe, Seattle, Sewell, Tyler, Vancouver, Waukee, Westbury, Weston, Winston-Salem
Age
18 years and over
People
630 worldwide
Run by
BeOne Medicines
See details and how to joinNCT06943872 · EU 2024-517131-52-00
Phase 1Taking people
A Vaccine (CMV-MVA Triplex Vaccine) for the Enhancement of CMV-Specific Immunity and the Prevention of CMV Viremia in Patients Undergoing Haploidentical Hematopoietic Stem Cell Transplant
Where
Atlanta, Boston, Duarte
Age
18 years to 75 years
People
46
Run by
City of Hope Medical Center
See details and how to joinNCT07020533
Phase 2Taking people
MAVRiC Studies 2L Treatment With AV in Patients With CLL/SLL Who Have Relapsed After a Course of BTKi + BCL2i Combination, With or Without Obinutuzumab
Where
Boston, Charlotte, Durham, Winston-Salem
Age
18 years to 130 years
People
80 worldwide
Run by
AstraZeneca
See details and how to joinNCT07024706 · EU 2024-518858-17-00
Early phase 1Taking people
Immune Profiling of CLL/SLL Treated With First-Line Pirtobrutinib
Where
Bethesda
Age
18 years to 100 years
People
30
Run by
National Heart, Lung, and Blood Institute (NHLBI)
See details and how to joinNCT07428707
Phase 2Taking people
Phase 2 Study of Glofitamab Monotherapy & With Polatuzumab Vedotin, Pirtobrutinib, or Atezolizumab in Richter's Transformation
Where
Atlanta, Boston, Chapel Hill, Columbus
Age
18 years and over
People
70
Run by
Christine Ryan
See details and how to joinNCT06043674