Colorectal cancer trials in Germany

In Germany 104 Also abroad 1941

104 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 14 November 2026. Ask the study team whether a trial fits you.

No phaseNot yet taking people in Germany
Modulated Mid-frequency Whole-body Electromyostimulation and Nutritional Therapy in Gastrointestinal Cancer Patients
Where
Cologne
Age
18 years and over
People
88
Run by
University of Cologne
See details and how to joinNCT06414122
No phaseTaking people
Colorectal Resections in Patients With Retroperitoneal Sarcoma
Where
Berlin, Cologne, Dresden, Erlangen, Göttingen, Greifswald, Halle, Hamburg, Hanover, Heidelberg, Magdeburg, Mannheim, München, Tübingen, Ulm
Age
18 years and over
People
120 worldwide
Run by
Heidelberg University
See details and how to joinNCT06943612
Phase 3Taking people
A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer
Where
Amberg, Berlin, Chemnitz, Dresden, Frankfurt am Main, Hamburg, Hanover, Leipzig, Moenchengladbach, Munich, Ulm
Age
18 years and over
People
400 worldwide
Run by
Seagen, a wholly owned subsidiary of Pfizer
See details and how to joinNCT05253651 · EU 2024-514180-25-00
Phase 2Taking people
Randomized Study to Evaluate Melphalan/HDS Treatment Followed by Trifluridine–tipiracil plus Bevacizumab Versus Trifluridine–tipiracil plus Bevacizumab Alone in Metastatic Colorectal Cancer Patients
Where
Hamburg, Hanover, Leipzig
Age
18 years and over
People
35 worldwide
Run by
Delcath Systems Inc.
See details and how to join2024-520356-24-00
No phaseTaking people
Efficacy and Safety of the CG-100 Intraluminal Bypass Device
Where
Hamburg
Age
22 years to 70 years
People
250 worldwide
Run by
Colospan Ltd.
See details and how to joinNCT04184973
Phase 1/2Taking people
A Clinical Study to Test if an Investigational Treatment Called BNT314 When Used in Combination With Another Investigational Treatment Pumitamig (BNT327) and Chemotherapy, is Beneficial and Safe for Patients With Advanced Colorectal Cancer
Where
Hamburg
Age
18 years and over
People
482 worldwide
Run by
BioNTech SE
See details and how to joinNCT07079631 · EU 2025-521768-36-00
Phase 1/2Taking people
A Clinical Study of Arfolitixorin in Patients With mCRC
Where
Berlin, Dresden, Essen, Hamburg, Mannheim, Munich
Age
18 years and over
People
90
Run by
Isofol Medical AB
See details and how to joinNCT06922383 · EU 2024-516802-43-00
Phase 1/2Taking people
A FIH, Phase I/IIa, Trial Assessing Feasibility of Administrations of TIL-based Immunotherapy in Patients With Metastatic CRC and PC
Where
Frankfurt am Main
Age
18 years and over
People
12
Run by
CuraCell TX AB
See details and how to joinNCT07255664 · EU 2025-521227-70-00
Phase 2/3Not yet taking people in Germany
68Ga-FAPI-46 PET for imaging of gastrointestinal cancers: A prospective interventional single-arm clinical trial (FAPI-PET-GI)
Where
Essen, Muenster
Age
18 years and over
People
150
Run by
Universitaetsklinikum Essen AöR
See details and how to join2023-506030-70-00
No phaseTaking people
Leakage Rate of Ileo-COlic Sutured Anastomosis After Right Hemicolectomy
Where
Darmstadt, Göppingen, Lüneburg, Schwäbisch Hall
Age
18 years and over
People
249
Run by
Aesculap AG
See details and how to joinNCT07132970
Phase 2Taking people
– IKF/AIO-QUINTIS – A Randomized Phase II Trial Evaluating Fruquintinib in Combination with Tislelizumab in Microsatellite Stable / Proficient Mismatch Repair (MSS/pMMR) Metastatic Colorectal Cancer without Active Liver Metastases
Where
Amberg, Augsburg, Bad Saarow, Berlin, Bochum, Chemnitz, Duesseldorf, Essen, Esslingen am Neckar, Frankfurt am Main, Frankfurt Am Main, Halle, Hamburg, Hanover, Herne, Karlsruhe, Leipzig, Munich, Ravensburg, Schweinfurt, Trier, Ulm, Wiesbaden
Age
18 years and over
People
140 worldwide
Run by
Frankfurter Institut Fuer Klinische Krebsforschung IKF GmbH
See details and how to join2024-519929-38-00
Phase 1/2Taking people
A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements
Where
Dresden, Heidelberg
Age
12 years and over
People
500 worldwide
Run by
Turning Point Therapeutics, Inc.
See details and how to joinNCT03093116 · EU 2024-512606-25-00
Phase 1/2Taking people
Beamion BCGC-1: A study to find a suitable dose of zongertinib used alone and in combination with other treatments to test whether it helps people with different types of HER2+ cancer that has spread
Where
Dresden, Erlangen, Essen, Hamburg, Mannheim, Ulm
Age
18 years and over
People
181 worldwide
Run by
Boehringer Ingelheim International GmbH
See details and how to join2023-509566-38-00
Phase 1Taking people
Phase I open-label, multi-center study to evaluate the safety, tolerability, dosimetry, and preliminary activity of [177Lu]Lu-NNS309 in patients with pancreatic, lung, breast and colorectal cancers.
Where
Cologne, Essen, Munich, Rostock
Age
18 years and over
People
76 worldwide
Run by
Novartis Pharma AG
See details and how to join2023-510356-23-00
No phaseTaking people
GUIDE.MRD-01-CRC: Clinical Validation and Benchmarking of Top Performing ctDNA Diagnostics - Colorectal Cancer
Where
Hamburg
Age
18 years and over
People
590 worldwide
Run by
Claus Lindbjerg Andersen
See details and how to joinNCT06111105
No phaseNot yet taking people in Germany
External Beam Radiotherapy Combined With Endorectal High-dose-rate Brachytherapy in Elderly and Frail Patients With Rectal Cancer
Where
Cologne, Frankfurt am Main, Kempten, Leipzig
Age
70 years and over
People
80
Run by
University Hospital of Cologne
See details and how to joinNCT06729645
No phaseTaking people
Exogenous and Endogenous Risk Factors for Early-onset Colorectal Cancer
Where
Munich, Wuppertal
Age
18 years to 49 years
People
2,300 worldwide
Run by
San Raffaele University
See details and how to joinNCT05732623
No phaseTaking people
KIA-Korekt: Staged Unimodal-to-Multimodal AI Evaluation for Perioperative Risk Prediction in Colorectal Cancer
Where
Brandenburg an der Havel
Age
18 years and over
People
910
Run by
Rene Mantke
See details and how to joinNCT07537491
No phaseTaking people
The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study
Where
Tübingen
Age
18 years and over
People
8,000 worldwide
Run by
UMC Utrecht
See details and how to joinNCT04075305
Phase 2Taking people
Organ Preservation in Rectal Cancer by Dose Escalated MR Guided Adaptive Radiotherapy
Where
Tübingen
Age
18 years and over
People
100
Run by
University Hospital Tuebingen
See details and how to joinNCT07337876
Phase 2Taking people
Upfront Trastuzumab-Deruxtecan Plus Capecitabine and Bevacizumab for Patients With HER-2 Positive Metastatic Colorectal Cancer.
Where
Berlin, Frankfurt am Main, Hamburg
Age
18 years and over
People
42 worldwide
Run by
Gruppo Oncologico del Nord-Ovest
See details and how to joinNCT07407465 · EU 2024-519479-24-00
Phase 3Taking people
Study of Perioperative Dostarlimab in Participants With Untreated T4N0 or Stage III dMMR/MSI-H Resectable Colon Cancer
Where
Berlin, Duesseldorf, Frankfurt am Main, Luebeck, Mannheim, Munich
Age
18 years and over
People
892 worldwide
Run by
GlaxoSmithKline
See details and how to joinNCT05855200 · EU 2023-503265-27-00
Phase 4Taking people
Effect on Body Movement and Mental Skills in Patients Who Received Gadolinium-based Contrast Media for Magnetic Resonance Examination Multiple Times Within 5 Years
Where
Berlin, Tübingen
Age
18 years to 64 years
People
2,076 worldwide
Run by
Guerbet
See details and how to joinNCT04373564
No phaseTaking people
Risk Factors for Neuroendocrine Neoplasms
Where
Nuremberg
People
14,250
Run by
Bavarian Cancer Registry
See details and how to joinNCT06282016
Phase 2Taking people
Futibatinib in Combination With (Chemo)Immunotherapy in Colorectal Cancer and Other Solid Tumor Entities
Where
Amberg, Berlin, Duesseldorf, Essen, Frankfurt am Main, Hamburg, Mainz, Munich, Ravensburg, Schweinfurt
Age
18 years and over
People
33
Run by
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
See details and how to joinNCT06722183 · EU 2024-517573-24-00