Colorectal cancer trials in Spain

In Spain 148 Also abroad 1929

148 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 12 November 2026. Ask the study team whether a trial fits you.

Phase 2Taking people
Neoadjuvant Pembrolizumab and Porustobart in Resectable pMMR/MSS Colon Cancer
Where
Barcelona, L'Hospitalet de Llobregat, Madrid
Age
18 years and over
People
100 worldwide
Run by
Solstice Oncology, Inc.
See details and how to joinNCT07808151 · EU 2026-527233-58-00
Phase 3Not yet taking people in Spain
Study of Petosemtamab Plus Chemotherapy Versus Cetuximab Plus Chemotherapy in RAS and BRAF Wild-type, Unresectable or Metastatic, Left-sided Colorectal Cancer.
Where
Badalona, Barcelona, Elche, L'Hospitalet de Llobregat, Lleida, Madrid, Majadahonda, Málaga, Pamplona, Pozuelo de Alarcón, Torrejón de Ardoz, Valencia, Zaragoza
Age
18 years and over
People
450 worldwide
Run by
Genmab A/S
See details and how to join2026-525883-17-00 · EU 2026-525883-17-00
Phase 1/2Taking people
A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)
Where
Barcelona, L'Hospitalet de Llobregat, Madrid, Sevilla
Age
18 years and over
People
680 worldwide
Run by
Daiichi Sankyo
See details and how to joinNCT06330064 · EU 2023-509632-26-00
Phase 2/3Taking people
A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer
Where
Badalona, Barcelona, Elche, Madrid, Málaga, Pamplona, Salamanca, Santiago de Compostela, Sevilla
Age
18 years and over
People
990 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT07221357 · EU 2025-523224-45-00
Phase 1/2Taking people
A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors
Where
A Coruña, Badalona, Barcelona, Córdoba, Elche, El Palmar, Girona, Lleida, Madrid, Málaga, Pamplona, Pozuelo de Alarcón, Rioja, Sabadell, Santander, Seville, Valencia, Zaragoza
Age
18 years and over
People
542 worldwide
Run by
Artios Pharma Ltd
See details and how to joinNCT04657068
Phase 1Taking people
A Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of VVD-133214 as Monotherapy and in Combination in Participants With Advanced Solid Tumors
Where
Barcelona, Madrid, Pamplona, Valencia
Age
18 years and over
People
280 worldwide
Run by
Vividion Therapeutics, Inc.
See details and how to joinNCT06004245 · EU 2023-503170-20-01
Phase 2Taking people
A Study to Evaluate the Efficacy of VVD-133214 in Combination With Pembrolizumab Compared With Pembrolizumab Alone in Participants With Advanced Cancer of the Colon or Rectum
Where
Barcelona, Madrid, Málaga, Santiago de Compostela, Valencia
Age
18 years and over
People
140 worldwide
Run by
Vividion Therapeutics, Inc.
See details and how to joinNCT07811193 · EU 2026-525507-26-00
Phase 2Taking people
Evaluation of the Safety and Efficacy of Treatment w/High Dose Melphalan Given Directly Into the Liver Followed by Treatment w/Approved Cancer Treatment or Approved Cancer Treatment Alone in Patients w/ Metastatic Colorectal Cancer w/Liver Dominant Disease
Where
Barcelona
Age
18 years and over
People
90 worldwide
Run by
Delcath Systems Inc.
See details and how to joinNCT06607458
Phase 2Taking people
Study of Denikitug (GS-1811) Given Alone or With Nivolumab or With Chemotherapy in Adults With Advanced Colorectal Cancer
Where
Madrid
Age
18 years and over
People
170 worldwide
Run by
Gilead Sciences
See details and how to joinNCT07527858
Phase 1/2Taking people
A Study to Test the Safety and Effectiveness of GSK5764227, Alone or With Other Treatments, in Participants With Advanced Gastrointestinal Cancers That Cannot be Surgically Removed (EMBOLD PanGI-201)
Where
Barcelona, Madrid, Pamplona, Santander, Zaragoza
Age
18 years and over
People
346 worldwide
Run by
GlaxoSmithKline
See details and how to joinNCT06885034
Phase 3Taking people
A Study to Access Intravenous (IV) Telisotuzumab Adizutecan in Combination With IV Bevacizumab Compared to Standard of Care IV Bevacizumabin Combination With Oral Trifluridine and Tipiracil in Adult Participants With Refractory Metastatic Colorectal Cancer
Where
Barcelona, Córdoba, Madrid, Valencia, Zaragoza
Age
18 years and over
People
990 worldwide
Run by
AbbVie
See details and how to joinNCT07525206 · EU 2025-521712-19-00
Phase 3Taking people
A Randomized, Active-Controlled, Double-blind, Multicenter, Phase 3 Clinical Study of Ivonescimab in Combination with FOLFOX versus Bevacizumab in Combination with FOLFOX for the First-line Treatment of Metastatic Colorectal Cancer (HARMONi-GI3)
Where
A Coruña, Badalona, Barcelona, Córdoba, Donostia, Granada, L'Hospitalet de Llobregat, Madrid, Majadahonda, Málaga, Palma, Santander, Sevilla, Valencia
Age
18 years and over
People
230 worldwide
Run by
Summit Therapeutics Inc.
See details and how to join2025-521587-35-00 · EU 2025-521587-35-00
Phase 1/2Taking people
A Clinical Trial to Test if the Investigational Drug BNT329 is Safe and Potentially Beneficial for People With Advanced Solid Tumors Known to Express the Tumor Marker CA19-9
Where
Barcelona, Logroño, Madrid, Pozuelo de Alarcón
Age
18 years and over
People
245 worldwide
Run by
BioNTech SE
See details and how to joinNCT07186842 · EU 2025-522613-26-00
Phase 2Not yet taking people in Spain
A Study of Olomorasib (LY3537982) in Participants With Advanced Colorectal Cancer and a KRAS G12C Mutation
Where
Barcelona, Jaén, Madrid, Santa Cruz de Tenerife, Santander, Santiago de Compostela
Age
18 years and over
People
50 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07814417 · EU 2026-526138-23-00
Phase 1/2Taking people
Phase 1b/2 dose-escalation trial of OMTX705, an anti-fibroblast activation protein antibody-drug conjugate, in combination with regorafenib and tislelizumab in patients with advanced/metastatic colorectal cancer
Where
Donostia, L'Hospitalet de Llobregat, Madrid, Pamplona, Santiago de Compostela
Age
18 years to 64 years
People
69
Run by
Oncomatryx Biopharma S.A.
See details and how to join2025-520743-33-00 · EU 2025-520743-33-00
Phase 4Taking people
A biomarker enrichment trial of anti-EGFR agents in patients with advanced colorectal cancer (aCRC) with wild-type RAS and right primary tumour location (right-PTL) - ARIEL-ENGIC 04 EU trial
Where
Badalona, Barcelona, Córdoba, Granada, L'hospitalet De Llobregat, Madrid, Málaga, Ourense, Pamplona, Salamanca, Santander, Valencia, Zaragoza
Age
18 years and over
People
120 worldwide
Run by
Fondazione GONO G.I.
See details and how to join2025-521209-42-00 · EU 2025-521209-42-00
Phase 1Taking people
KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors
Where
Barcelona, Madrid, Sevilla
Age
18 years and over
People
300 worldwide
Run by
Kura Oncology, Inc.
See details and how to joinNCT06026410 · EU 2024-513285-19-00
Phase 1/2Taking people
Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies
Where
Barcelona, Madrid, Pamplona, Valencia
Age
18 years and over
People
554 worldwide
Run by
Institut de Recherches Internationales Servier
See details and how to joinNCT05786924 · EU 2025-523474-16-00
Phase 2Taking people
A Study to Assess Adverse Events and Change in Disease Activity in Adult Participants Receiving Intravenously Infused Telisotuzumab Adizutecan Alone or With Standard of Care in Participants With Post Adjuvant Circulating Tumor DNA Positive Colorectal Cancer and No Radiographic Evidence of Disease
Where
Madrid, Salamanca, Sevilla
Age
18 years and over
People
140 worldwide
Run by
AbbVie
See details and how to joinNCT07023289 · EU 2024-518015-19-00
No phaseTaking people
Performance and Safety of MiWEndo-assisted Colonoscopy (MiWEndo II)
Where
Barcelona
Age
18 years and over
People
50
Run by
MiWEndo Solutions S.L.
See details and how to joinNCT05988645
Phase 3Taking people
Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer
Where
Barcelona, Córdoba, Jerez de la Frontera, L'Hospitalet de Llobregat, Madrid, Málaga, Santiago de Compostela, Valencia, Zaragoza
Age
18 years and over
People
800 worldwide
Run by
Pfizer
See details and how to joinNCT07222800 · EU 2025-523521-18-00
Phase 1Taking people
A Study to Learn More About How Safe BAY 3771249 is and How Well it Works in People With Advanced or Metastatic Colorectal Cancer That Has a KRAS G12D Mutation
Where
Barcelona, Madrid
Age
18 years and over
People
130 worldwide
Run by
Bayer
See details and how to joinNCT07535112 · EU 2025-523648-11-00
Phase 1/2Taking people
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
Where
Barcelona, Madrid, Rioja, Valencia
Age
12 years and over
People
300 worldwide
Run by
PMV Pharmaceuticals, Inc
See details and how to joinNCT04585750
Phase 1Taking people
A Phase 1 Study of PLN-101095 in Adults With Advanced or Metastatic Solid Tumors
Where
Barcelona, Logroño, Madrid
Age
18 years and over
People
124 worldwide
Run by
Pliant Therapeutics, Inc.
See details and how to joinNCT06270706
Phase 1Taking people
Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
Where
Badajoz, Barcelona, Madrid, Pamplona, Santander, Sevilla, Valencia
Age
18 years and over
People
1,394 worldwide
Run by
Exelixis
See details and how to joinNCT05176483 · EU 2023-510061-10-00