Colorectal cancer trials in France

In France 184 Also abroad 1930

184 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 1/2Taking people
A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors
Where
Lyon, Marseille, Paris
Age
18 years and over
People
616 worldwide
Run by
Verastem, Inc.
See details and how to joinNCT07020221
No phaseTaking people
Analysis of Circulating Tumor Markers in Blood
Where
Montpellier
Age
18 years and over
People
992
Run by
Institut du Cancer de Montpellier - Val d'Aurelle
See details and how to joinNCT04025541
No phaseNot yet taking people in France
Multidimensional Study Designed to Develop a Methodological Framework Based on MRI Data to Predict Pathological Complete Response (pCR) in Patients With Locally Advanced Rectal Cancer After Neoadjuvant Treatment
Where
Montpellier
Age
18 years and over
People
115
Run by
Institut du Cancer de Montpellier - Val d'Aurelle
See details and how to joinNCT07404228
Phase 1/2Taking people
Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread
Where
Bordeaux, Caen, Lyon, Marseille, Paris, Rennes, Saint-Herblain, Strasbourg, Toulouse, Villejuif
Age
18 years and over
People
910 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT06324357
Phase 3Taking people
Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer
Where
Bordeaux, Lille, Lyon, Marseille, Montpellier, Nancy, Nantes, Nice, Paris, Pierre-Bénite, Poitiers, Reims, Strasbourg, Villejuif
Age
18 years and over
People
900 worldwide
Run by
Summit Therapeutics
See details and how to joinNCT07228832
Phase 1Taking people
A Study to Learn About the Study Medicine Called PF-08032562 in People With Advanced or Metastatic Solid Tumors
Where
Poitiers, Villejuif Cedex
Age
18 years and over
People
260 worldwide
Run by
Pfizer
See details and how to joinNCT07318805 · EU 2025-524387-38-00
Phase 3Taking people
A Study of Precemtabart Tocentecan With or Without Bevacizumab Compared to Trifluridine/Tipiracil Plus Bevacizumab in Participants With Previously Treated Metastatic Colorectal Cancer (PROCEADE-CRC-03)
Where
Bordeaux, Caen Cedex 5, Lille Cedex, Lyon, Marseille, Paris, Saint-Priest-en-Jarez, Villejuif
Age
18 years and over
People
1,020 worldwide
Run by
EMD Serono Research & Development Institute, Inc.
See details and how to joinNCT07549412 · EU 2025-524648-37-00
Phase 1Taking people
A Study of Sofe-M in Participants With Selected Advanced Solid Tumors
Where
Lyon, Saint-Herblain Cedex, Toulouse Cedex 9
Age
18 years and over
People
575 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT06400472 · EU 2024-511238-11-00
Phase 2Taking people
Regorafenib in Combination With Multimodal Metronomic Chemotherapy for Chemo-resistant Metastatic Colorectal Cancers
Where
Auxerre, Besançon, Chalon-sur-Saône, Colmar, Dijon, Lyon, Metz, Montbéliard, Montpellier, Nancy, Reims, Strasbourg
Age
18 years and over
People
174
Run by
Centre Hospitalier Universitaire de Besancon
See details and how to joinNCT06425133
Phase 2Taking people
A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)
Where
Bordeaux, Brest, Lille, Montpellier, Pierre-Bénite, Villejuif
Age
18 years and over
People
111 worldwide
Run by
Bayer
See details and how to joinNCT06760819 · EU 2024-517419-62-00
Phase 3Taking people
A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)
Where
Angers, Avignon, Caen Cedex 5, Limoges, Nice, Paris, Reims, Rouen, Toulouse Cedex 9, Vandoeuvre Les Nancy Cedex
Age
18 years and over
People
477 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT06997497 · EU 2024-517232-22-00
Phase 1Taking people
A Study of LY4257496 in Participants With Cancer (OMNIRAY)
Where
Paris, Saint-Herblain
Age
18 years and over
People
421 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07114601 · EU 2025-522367-15-00
Phase 3Taking people
A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer
Where
Avignon Cedex 9, Lille, Lyon, Montpellier Cedex 5, Nantes, Paris, Pessac, Poitiers, Villejuif
Age
18 years and over
People
1,000 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT06662786 · EU 2024-513852-13-00
Phase 3Taking people
A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy
Where
Avignon Cedex 9, Pessac, Poitiers
Age
18 years and over
People
700 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT06750094 · EU 2024-513853-66-00
Phase 1/2Taking people
A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors
Where
Bordeaux, Lyon, Marseille, Montpellier Cedex 5, Nice Cedex 2, Paris, Rouen Cedex, Villejuif
Age
18 years and over
People
560 worldwide
Run by
Genmab
See details and how to joinNCT03526835 · EU 2024-513627-16-01
Phase 1/2Taking people
EIK1005-002: A Clinical Research Study Evaluating EIK1005, a Werner Helicase Inhibitor, as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors Including Microsatellite Instability High (MSI-H) Tumors
Where
Pierre-Bénite
Age
18 years and over
People
160 worldwide
Run by
Eikon Therapeutics
See details and how to joinNCT07262619 · EU 2026-525248-13-00
Phase 3Taking people
A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer
Where
Marseille, Paris, Paris Cedex 15, Pessac, Poitiers, Reims Cedex, Saint-Priest-en-Jarez, Toulouse Cedex 9, Villejuif
Age
18 years and over
People
700 worldwide
Run by
Incyte Corporation
See details and how to joinNCT07284849 · EU 2025-523735-19-00
No phaseTaking people
The French Gut-colo
Where
Bobigny
Age
50 years to 75 years
People
2,500
Run by
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
See details and how to joinNCT06174233
Phase 1Taking people
A Study to Find a Suitable Dose of ASP5834 in Adults With Solid Tumors
Where
Bordeaux, Lyon, Pierre-Bénite, Villejuif
Age
18 years and over
People
404 worldwide
Run by
Astellas Pharma Inc
See details and how to joinNCT07094204 · EU 2025-522082-29-00
Phase 2Taking people
A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer
Where
Lille, Lyon, Nantes, Paris, Poitiers
Age
18 years and over
People
390 worldwide
Run by
AbbVie
See details and how to joinNCT06820463 · EU 2024-512981-33-00
Phase 3Not yet taking people in France
Study of Petosemtamab Plus Chemotherapy Versus Cetuximab Plus Chemotherapy in RAS and BRAF Wild-type, Unresectable or Metastatic, Left-sided Colorectal Cancer.
Where
Avignon Cedex 9, Brest, Caen Cedex 5, Dijon, La Chaussee St Victor, Lyon, Marseille, Montpellier Cedex 5, Nantes, Paris, Pierre-Bénite, Reims, Rennes, Saint-Herblain Cedex, Strasbourg, Tours
Age
18 years and over
People
450 worldwide
Run by
Genmab A/S
See details and how to join2026-525883-17-00 · EU 2026-525883-17-00
Phase 1/2Taking people
A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)
Where
Besancon Cedex, Bordeaux, Bordeaux Cedex, Dijon, Lyon, Montpellier Cedex 5, Paris, Rennes Cedex, Saint-Herblain Cedex, Toulouse Cedex 9, Villejuif
Age
18 years and over
People
680 worldwide
Run by
Daiichi Sankyo
See details and how to joinNCT06330064 · EU 2023-509632-26-00
No phaseTaking people
Impact of a Multidisciplinary Approach in the Perioperative Geriatrics Unit on Functional Status of Patients Aged 70 and Over Operated on for Colorectal Cancer
Where
Nîmes
Age
70 years and over
People
90
Run by
Centre Hospitalier Universitaire de Nīmes
See details and how to joinNCT05993923
Phase 2/3Taking people
A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer
Where
Besancon Cedex, Dijon, Lille, Limoges Cedex 1, Lorient, Marseille, Nantes, Paris, Pessac, Rouen, Saint-Herblain Cedex, Suresnes, Toulouse, Villejuif
Age
18 years and over
People
990 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT07221357 · EU 2025-523224-45-00
Phase 1/2Taking people
A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors
Where
Bordeau, Marseille, Paris, Poitiers, Villejuif
Age
18 years and over
People
542 worldwide
Run by
Artios Pharma Ltd
See details and how to joinNCT04657068