Colorectal cancer trials in Italy

In Italy 157 Also abroad 1929

157 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 12 November 2026. Ask the study team whether a trial fits you.

Phase 2Taking people
Evaluation of the Safety and Efficacy of Treatment w/High Dose Melphalan Given Directly Into the Liver Followed by Treatment w/Approved Cancer Treatment or Approved Cancer Treatment Alone in Patients w/ Metastatic Colorectal Cancer w/Liver Dominant Disease
Where
Milan
Age
18 years and over
People
90 worldwide
Run by
Delcath Systems Inc.
See details and how to joinNCT06607458
Phase 1/2Taking people
A Study to Test the Safety and Effectiveness of GSK5764227, Alone or With Other Treatments, in Participants With Advanced Gastrointestinal Cancers That Cannot be Surgically Removed (EMBOLD PanGI-201)
Where
Milan, Pisa, Roma
Age
18 years and over
People
346 worldwide
Run by
GlaxoSmithKline
See details and how to joinNCT06885034
Phase 3Taking people
A Randomized, Active-Controlled, Double-blind, Multicenter, Phase 3 Clinical Study of Ivonescimab in Combination with FOLFOX versus Bevacizumab in Combination with FOLFOX for the First-line Treatment of Metastatic Colorectal Cancer (HARMONi-GI3)
Where
Aviano, Bologna, Brescia, Cagliari, Candiolo, Catania, Florence, Genoa, Meldola, Milan, Naples, Orbassano, Padova, Pisa, Rome, Rozzano, San Giovanni Rotondo, Verona
Age
18 years and over
People
230 worldwide
Run by
Summit Therapeutics Inc.
See details and how to join2025-521587-35-00 · EU 2025-521587-35-00
Phase 4Taking people
A biomarker enrichment trial of anti-EGFR agents in patients with advanced colorectal cancer (aCRC) with wild-type RAS and right primary tumour location (right-PTL) - ARIEL-ENGIC 04 EU trial
Where
Aviano, Catania, Florence, Livorno, Meldola, Milan, Modena, Monserrato, Padova, Pisa, Ravenna, Rome, San Giovanni Rotondo, Tricase, Ospedale di Prato Santo Stefano
Age
18 years and over
People
120 worldwide
Run by
Fondazione GONO G.I.
See details and how to join2025-521209-42-00 · EU 2025-521209-42-00
Phase 1Taking people
KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors
Where
Bologna, Candiolo, Naples, Rozzano, Verona
Age
18 years and over
People
300 worldwide
Run by
Kura Oncology, Inc.
See details and how to joinNCT06026410 · EU 2024-513285-19-00
No phaseTaking people
Stigma and Psychological profilE in REctal-anal caNcer pAtients
Where
Roma
Age
18 years to 75 years
People
148
Run by
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
See details and how to joinNCT06366841
Phase 1/2Taking people
Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies
Where
Milan, Rome, Rozzano
Age
18 years and over
People
554 worldwide
Run by
Institut de Recherches Internationales Servier
See details and how to joinNCT05786924 · EU 2025-523474-16-00
Phase 2Taking people
STREAM-2: Second-line Treatment With REgorafenib in Advanced RAS-Mutant Colorectal Cancer
Where
Avellino, Caserta, Località la Schiana, Pozzuoli (NA), Naples, Napoli, Potenza, San Giovanni Rotondo, Tricase
Age
18 years and over
People
60
Run by
National Cancer Institute, Naples
See details and how to joinNCT07213570 · EU 2024-519669-23-00
Phase 2Taking people
A Study to Assess Adverse Events and Change in Disease Activity in Adult Participants Receiving Intravenously Infused Telisotuzumab Adizutecan Alone or With Standard of Care in Participants With Post Adjuvant Circulating Tumor DNA Positive Colorectal Cancer and No Radiographic Evidence of Disease
Where
Florence, Naples, Rozzano
Age
18 years and over
People
140 worldwide
Run by
AbbVie
See details and how to joinNCT07023289 · EU 2024-518015-19-00
Phase 3Taking people
Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer
Where
Florence, Milan, Naples, Padova, Pisa, Rome, Tricase, Udine
Age
18 years and over
People
800 worldwide
Run by
Pfizer
See details and how to joinNCT07222800 · EU 2025-523521-18-00
Phase 2Taking people
Temozolomide and irinotecan consolidation in patients with MGMT silenced, microsatellite stable colorectal cancer with persistence of minimal residual disease in liquid biopsy after standard adjuvant chemotherapy: the ERASE-TMZ study
Where
Ancona, Aviano, Brescia, Candiolo, Catania, Cremona, Cuneo, Faenza, Florence, Genoa, Meldola, Milan, Modena, Monserrato, Monza, Naples, Padova, Pisa, Prato, Reggio Emilia, Rome, Tricase, Turin, Udine, Vicenza
Age
18 years and over
People
25
Run by
Fondazione IRCCS Istituto Nazionale Dei Tumori
See details and how to join2024-515681-14-00 · EU 2024-515681-14-00
Phase 1Taking people
A Study to Learn More About How Safe BAY 3771249 is and How Well it Works in People With Advanced or Metastatic Colorectal Cancer That Has a KRAS G12D Mutation
Where
Roma
Age
18 years and over
People
130 worldwide
Run by
Bayer
See details and how to joinNCT07535112 · EU 2025-523648-11-00
Phase 1/2Taking people
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
Where
Candiolo, Milan, Naples, Rome, Rozzano
Age
12 years and over
People
300 worldwide
Run by
PMV Pharmaceuticals, Inc
See details and how to joinNCT04585750
Phase 1Taking people
Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
Where
Ancona, Bologna, Florence, Milan, Naples, Ravenna
Age
18 years and over
People
1,394 worldwide
Run by
Exelixis
See details and how to joinNCT05176483 · EU 2023-510061-10-00
Phase 2Taking people
Phase II study of adjuvant pressurized intraperitoneal aerosol chemotherapy (PIPAC) for the prevention of peritoneal metastases after curative-intent surgery for high-risk colorectal cancer.
Where
Milan
Age
18 years and over
People
30
Run by
Fondazione IRCCS Istituto Nazionale Dei Tumori
See details and how to join2024-513376-17-00 · EU 2024-513376-17-00
Phase 2Taking people
Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)
Where
Milan, Naples
Age
18 years to 130 years
People
454 worldwide
Run by
AstraZeneca
See details and how to joinNCT05489211 · EU 2023-509436-26-00
Phase 1/2Taking people
Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors
Where
Ancona, Aviano, Meldola, Milan, Naples, Orbassano, Ravenna, Verona
Age
18 years and over
People
534 worldwide
Run by
Revolution Medicines, Inc.
See details and how to joinNCT06128551
Phase 2/3Taking people
NeoAspMet - Neoadjuvant Aspirin and/or Metformin during preoperative induction chemotherapy and chemoradiotherapy for locally-advanced rectal cancer. A multi-arm, multi-stage, intergroup (STAR-04/SICO-CR01/GISCAD/AIRO-GI) randomised clinical trial. The NeoAspMet trial
Where
Aviano, Bari, La Spezia, Milan, Modena, Monserrato, Monza, Naples, Novara, Orbassano, Padova, Palermo, Pinerolo, Ponderano, Potenza, Ragusa, Reggio Emilia, Rome, Sondrio, Statte, Taormina (Italy), Treviglio, Turin, Udine
Age
18 years and over
People
340
Run by
IRCCS Istituto Nazionale Tumori Fondazione Pascale
See details and how to join2024-519007-10-00 · EU 2024-519007-10-00
Phase 1/2Taking people
A Study to Investigate the Safety and Preliminary Efficacy of GSK5460025 Alone or in Combination With Other Anti-cancer Agents in Participants With Solid Tumors
Where
Milan
Age
18 years and over
People
47 worldwide
Run by
GlaxoSmithKline
See details and how to joinNCT07213609
Phase 2Taking people
[68Ga]BED003 PET Imaging of Fibroblast Activation Protein in Selected Oncology Indications
Where
Bergamo, Milan, Monza, Rome
Age
18 years to 79 years
People
71 worldwide
Run by
Blue Earth Diagnostics
See details and how to joinNCT07702292 · EU 2025-521983-36-00
No phaseTaking people
ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation
Where
Meldola, Reggio Emilia, Roma
Age
18 years and over
People
2,285 worldwide
Run by
Guardant Health, Inc.
See details and how to joinNCT05059444
Phase 2Taking people
Pre-operative Targeted Treatments in Molecularly Selected Resectable Colorectal Cancer (UNICORN)
Where
Milan
Age
18 years and over
People
197
Run by
Gruppo Oncologico del Nord-Ovest
See details and how to joinNCT05845450
Phase 2Taking people
ROMANCE: "Irinotecan Plus Cetuximab Rechallenge Versus Trifluridine/Tipiracil Plus Bevacizumab in Molecularly Selected Metastatic Colorectal Cancer"
Where
Alexandria, Ancona, Avellino, Aviano, Brescia, Caserta, Castellana Grotte, Catania, Catanzaro, Florence, Meldola, Milan, Milano, Mirabella Eclano, Modena, Naples, Padova, Palermo, Pavia, Pisa, Rome, Rozzano, San Giovanni Rotondo, Sassari, Statte, Tricase, Varese
Age
18 years and over
People
150
Run by
Gruppo Oncologico Italia Meridionale
See details and how to joinNCT07381764 · EU 2025-521319-38-00
Phase 2Taking people
A study to evaluate the safety and efficacy of two dose levels of ONO-4578 with Opdivo®, in combination with mFOLFOX6 and bevacizumab versus standard of care in participants with non MSI-H/dMMR, PD-L1 positive advanced colorectal cancer.
Where
Milan, Naples, Padova, Rozzano
Age
18 years and over
People
76 worldwide
Run by
Ono Pharmaceutical Co. Ltd.
See details and how to join2024-519590-19-00 · EU 2024-519590-19-00
Phase 1Taking people
A Phase 1/1b Study of IAM1363 in HER2 Cancers
Where
Florence, Milan, Naples
Age
18 years and over
People
383 worldwide
Run by
Iambic Therapeutics, Inc
See details and how to joinNCT06253871