Colorectal cancer trials in Japan

In Japan 47 Also abroad 1941

47 trials · From ClinicalTrials.gov, checked 15 November 2026. Ask the study team whether a trial fits you.

Phase 1/2Taking people
A Study to Investigate the Safety and Preliminary Efficacy of GSK5460025 Alone or in Combination With Other Anti-cancer Agents in Participants With Solid Tumors
Where
Chiba, Osaka, Tokyo
Age
18 years and over
People
47 worldwide
Run by
GlaxoSmithKline
See details and how to joinNCT07213609
Phase 3Taking people
Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation
Where
Akashi-shi, Bunkyo-ku, Bunkyo Ku, Chiba, Chuo Ku, Fukuoka, Hirakata-shi, Kashiwa-shi, Kawasaki-shi, Kitaadachi-gun, Koto-ku, Matsuyama, Nagoya, Niigata, Osaka, Sapporo, Suita-shi, Sunto-gun, Tokushima, Yokohama
Age
18 years and over
People
450 worldwide
Run by
Amgen
See details and how to joinNCT06252649
Phase 1Taking people
Phase I Study of JFI447 [68Ga]Ga-DFC413 and Comparison to FFG233 [68Ga]Ga-NNS309 in Patients With Solid Tumors
Where
Chuo Ku
Age
18 years and over
People
66 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT07630961
Phase 1/2Taking people
A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With Advanced Solid Tumors
Where
Kashiwa
Age
18 years and over
People
1,109 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT04895709
Phase 1Taking people
AB122 Platform Study
Where
Aichi, Chiba, Ehime, Hokkaido, Kanagawa, Osaka, Shizuoka, Tokyo, Wakayama
Age
18 years and over
People
917
Run by
Taiho Pharmaceutical Co., Ltd.
See details and how to joinNCT04999761
Phase 1Taking people
AMG 410 Alone and in Combination With Other Agents in Participants With KRAS Altered Advanced or Metastatic Solid Tumors
Where
Chuo Ku, Kashiwa-shi, Nagoya
Age
18 years and over
People
434 worldwide
Run by
Amgen
See details and how to joinNCT07094113
Phase 3Taking people
A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer
Where
Chiba, Chuo Ku, Fukuoka, Kashiwa-shi, Kawasaki-shi, Kitaadachi-gun, Kita-gun, Kobe, Koto-Ku, Matsuyama, Osaka, Osakasayama-Shi, Sakai, Sapporo, Suita, Takatsuki-shi, Yokohama
Age
18 years and over
People
400 worldwide
Run by
Seagen, a wholly owned subsidiary of Pfizer
See details and how to joinNCT05253651 · EU 2024-514180-25-00
Phase 1Taking people
A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors
Where
Kashiwa
Age
18 years and over
People
914 worldwide
Run by
Seagen, a wholly owned subsidiary of Pfizer
See details and how to joinNCT06131840 · EU 2023-505858-18-00
Phase 1Taking people
A Study to Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation
Where
Chiba, Tokyo
Age
18 years and over
People
710 worldwide
Run by
Incyte Corporation
See details and how to joinNCT06179160 · EU 2023-507091-47-00
Phase 2Taking people
A Study to Evaluate the Safety and Efficacy of Two Dose Levels of ONO-4578 With Opdivo®, in Combination With mFOLFOX6 and Bevacizumab Versus Standard of Care in Participants With Non-MSI-H/dMMR, PD-L1 Positive Advanced Colorectal Cancer
Where
Hyōgo, Osaka
Age
18 years and over
People
144 worldwide
Run by
Ono Pharmaceutical Co., Ltd.
See details and how to joinNCT06948448
No phaseTaking people
Early Onset Colorectal Cancer Detection
Where
Kawasaki, Mie, Tokyo, Yamagata
Age
18 years to 50 years
People
400 worldwide
Run by
City of Hope Medical Center
See details and how to joinNCT06342401
No phaseTaking people
Early Detection of Advanced Adenomas and Colorectal Cancer
Where
Mie
Age
18 years and over
People
2,000 worldwide
Run by
City of Hope Medical Center
See details and how to joinNCT06342440
Phase 1/2Taking people
A Clinical Study to Test if an Investigational Treatment Called BNT314 When Used in Combination With Another Investigational Treatment Pumitamig (BNT327) and Chemotherapy, is Beneficial and Safe for Patients With Advanced Colorectal Cancer
Where
Chūōku, Kashiwa
Age
18 years and over
People
482 worldwide
Run by
BioNTech SE
See details and how to joinNCT07079631 · EU 2025-521768-36-00
Phase 1Taking people
Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma and Other Solid Tumors, Receiving Intravenous Infusion of Azirkitug Alone or in Combination(s) With Budigalimab, Bevacizumab, or Telisotuzumab Adizutecan
Where
Chuo-ku, Hirakata-shi, Kashiwa-shi, Kobe, Nagoya, Sunto-gun, Wakayama
Age
18 years and over
People
694 worldwide
Run by
AbbVie
See details and how to joinNCT05005403
Phase 1/2Taking people
A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements
Where
Chuo Ku, Kashiwa, Nagoya, Osaka, Sapporo, Tōon, Yokohama, Yonago
Age
12 years and over
People
500 worldwide
Run by
Turning Point Therapeutics, Inc.
See details and how to joinNCT03093116 · EU 2024-512606-25-00
Phase 2Taking people
A Study of Neoadjuvant Dostarlimab Plus Capecitabine Plus Oxaliplatin (CAPEOX) Vs CAPEOX With Previously Untreated T4N0 or Stage III Mismatch Repair Proficient (MMRp)/Microsatellite Stable (MSS) Colon Cancer
Where
Osaka, Tokyo
Age
18 years and over
People
120 worldwide
Run by
GlaxoSmithKline
See details and how to joinNCT06567782
Phase 3Taking people
Study of Perioperative Dostarlimab in Participants With Untreated T4N0 or Stage III dMMR/MSI-H Resectable Colon Cancer
Where
Aichi, Chiba, Fukuoka, Hokkaido, Hyōgo, Ibaraki, Kanagawa, Kyoto, Okayama, Osaka, Shizuoka, Tokyo
Age
18 years and over
People
892 worldwide
Run by
GlaxoSmithKline
See details and how to joinNCT05855200 · EU 2023-503265-27-00
Phase 1Taking people
Study of a Tankyrase Inhibitor RK-582 for Patients With Unresectable Metastatic Colorectal Cancer
Where
Koto-Ku
Age
18 years and over
People
48
Run by
Eiji Shinozaki
See details and how to joinNCT06853496
Phase 3Taking people
TNT of SCRT+CAPOX vs SCRT+CAPOXIRI for Locally Advanced Rectal Cancer
Where
Chiba, Ehime, Fukuoka, Gifu, Hirosaki, Hiroshima, Kawasaki, Kitakyushu, Kochi, Kumamoto, Kyoto, Nagoya, Okayama, Osaka, Sagamihara, Sapporo, Tokyo, Yokohama, Yokosuka
Age
18 years and over
People
608
Run by
National Cancer Center Hospital East
See details and how to joinNCT05646511
Phase 2/3Not yet taking people in Japan
A Clinical Study to Evaluate Efficacy and Safety of Serplulimab（HLX10） Combined With Bevacizumab（HLX04) and Chemotherapy (XELOX) in Patients With Metastatic Colorectal Cancer (mCRC)
Where
Kashiwa
Age
18 years to 75 years
People
568 worldwide
Run by
Shanghai Henlius Biotech
See details and how to joinNCT04547166
Phase 2Taking people
A Multicenter Single-arm P2 to Evaluate Safety and Efficacy of the Total Neoadjuvant Therapy for cT2 Rectal Cancer
Where
Osaka
Age
18 years and over
People
45
Run by
Osaka University
See details and how to joinNCT05939661
Phase 3Taking people
Surgery Plus Chemo Versus Chemoradiotherapy Followed by Surgery Plus Chemo for Locally Recurrent Rectal Cancer
Where
Chiba, Gifu, Hidaka, Hirakata, Hiroshima, Izumo, Kanazawa, Kashiwa, Kawagoe, Kochi, Kumamoto, Kurashiki, Kurume, Matsuyama, Mitaka, Morioka, Nagoya, Niigata, Nishinomiya, Ōgaki, Okayama, Osaka, Ōta-ku, Saitama, Sapporo, Sendai, Shizuoka, Suita, Takatsuki, Tokorozawa, Tokyo, Utsunomiya, Yamagata, Yokohama, Yufu
Age
20 years to 80 years
People
110
Run by
National Cancer Center Hospital East
See details and how to joinNCT04288999