Depression: open trials in Germany

34 open trials have a site in Germany. Registry data; only the trial team decides who can take part.

NCT07775300
A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder
Trial Treatment · Phase 3 · Eli Lilly and Company
Charite Universitaetsmedizin Berlin KöR, Berlin · FutureMeds GmbH, Berlin · Pharmakologisches Studienzentrum Chemnitz GmbH, Chemnitz · Klinische Forschung Hamburg GmbH, Hamburg · Universitaet Leipzig, Leipzig · Somni bene Institut fuer medizinische Forschung und Schlafmedizin Schwerin GmbH, Schwerin
Registry updated 2026-11-03
NCT06793397
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
Trial Treatment · Phase 3 · Cybin IRL Limited
Charite Universitaetsmedizin Berlin KöR, Berlin · Goethe University Frankfurt, Frankfurt Am Main · Universitaet Des Saarlandes, Homburg · Zentralinstitut Fuer Seelische Gesundheit, Mannheim
Registry updated 2026-11-02
NCT07823218
Longitudinal Effects of Brain Stimulation on Decision-Making and Reward Learning
Research · University of Bonn
Section of Medical Psychology, Department of Psychiatry & Psychotherapy, Faculty of Medicine, University of Bonn, Bonn
Registry updated 2026-10-26
NCT07889739
Sensation Seeking and TMS Response in TRD
Research · Technical University of Munich
Technical University of Munich, TUM School of Medicine and Health, Department of Psychiatry and Psychotherapy,, München
Registry updated 2026-10-22
NCT06396312
Deep Phenotyping for Clinical Inferring Response in Treatment Resistant Depression
Research · Max-Planck-Institute of Psychiatry
Max Planck Insitute of Psychiatry, Munich
Registry updated 2026-10-09
NCT07197138
IMPACT-D+: Immune-Modulating and Psychometric Effects of Accelerated TMS in Depression Plus Comorbid Post-COVID-19 Condition
Trial Treatment · Max-Planck-Institute of Psychiatry
Max-Planck-Institute of Psychiatry, Munich
Registry updated 2026-10-07
NCT07065240
A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)
Trial Treatment · Phase 2 · Seaport Therapeutics
Zentrum fuer klinische Forschung Dr. I. Schoell GmbH, Bad Homburg · FutureMeds GmbH, Berlin · Pharmakologisches Studienzentrum Chemnitz GmbH, Chemnitz · Somni bene Institut fuer medizinische Forschung und Schlafmedizin Schwerin GmbH, Schwerin
Registry updated 2026-10-06
NCT07161700
An Open-Label Extension Study to Evaluate the Safety and Tolerability of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 OLE Study)
Trial Treatment · Phase 2 · Seaport Therapeutics
Zentrum fuer klinische Forschung Dr. I. Schoell GmbH, Bad Homburg · FutureMeds GmbH, Berlin · Pharmakologisches Studienzentrum Chemnitz GmbH, Chemnitz · Somni bene Institut fuer medizinische Forschung und Schlafmedizin Schwerin GmbH, Schwerin
Registry updated 2026-10-06
NCT07412756
A Study of Brenipatide in Adult Participants With Major Depressive Disorder
Trial Treatment · Phase 3 · Eli Lilly and Company
Universitätsklinikum Aachen, Aachen · FutureMeds Berlin, Berlin · Neurozentrum Bielefeld, Bielefeld · Pharmakologisches Studienzentrum Chemnitz, Chemnitz · Universitätsmedizin Johannes Gutenberg Universität Mainz, Mainz · ISPG - Institut für Studien zur Psychischen Gesundheit, Mannheim · Somni bene, Schwerin · ZNS Siegen, Siegen
Registry updated 2026-10-05
NCT07843927
Dehydroepiandrosterone (DHEA) as Augmentation of Standard Antidepressants in Treatment-resistant Depression.
Trial Treatment · Phase 3 · Charite University, Berlin, Germany
Bezirkskliniken Schwaben KU Anstalt des offentlichen Rechts des Bezirks Schwaben, Augsburg · Charite Universitaetsmedizin Berlin KöR, Berlin · Goethe University Frankfurt, Frankfurt Am Main · Medical Center- University of Freiburg, Freiburg im Breisgau · University Medical Center Hamburg-Eppendorf, Hamburg · Universitaet Leipzig, Leipzig · Ludwig-Maximilians-Universitaet Muenchen, Munich · HELIOS Hanseklinikum Stralsund GmbH, Stralsund
Registry updated 2026-09-28
NCT06605105
Phase III Long-term Extension Trial to Assess Safety and Efficacy of CYB003 in MDD (EXTEND)
Trial Treatment · Phase 3 · Cybin IRL Limited
Charite Universitaetsmedizin Berlin KöR, Berlin · Goethe University Frankfurt, Frankfurt Am Main · Universitaetsklinikum des Saarlandes AöR, Homburg · Zentralinstitut Fuer Seelische Gesundheit, Mannheim
Registry updated 2026-09-25
NCT06967857
Clinical Trial to Investigate the Safety and Efficacy of Two Dexamfetamine Sulfate Formulations in Adults With ADHD and Moderate to Severe Depression
Trial Treatment · Phase 2 · Prof. Dr. Frank Behrens
Charité - Universitätsmedizin Berlin Klinik für Psychiatrie und Psychotherapie, Campus Benjamin Franklin, Berlin · Universitätsklinikum Bonn AöR, Klinik und Poliklinik für Psychiatrie und Psychotherapie, Bonn · Department of Psychiatry, Psychosomatics and Psychotherapy University Hospital Frankfurt am Main - Goethe University, Frankfurt · University Leipzig, Department of Psychiatry and Psychotherapy, Leipzig · LMU Klinikum München Klinik für Psychiatrie und Psychotherapie, München
Registry updated 2026-09-25
2024-515395-12-00
Randomized, placebo-controlled clinical trial to investigate the safety and efficacy of two dexamfetamine sulfate formulations in adults with ADHD and moderate to severe depression (DEXAD)
Trial Treatment · Phase 2 · Fraunhofer Institute For Translational Medicine And Pharmacology ITMP
Charite Universitaetsmedizin Berlin KöR, Berlin · Universitaetsklinikum Bonn AöR, Bonn · Goethe University Frankfurt, Frankfurt Am Main · Universitaet Leipzig, Leipzig · Klinikum der Universitaet Muenchen AöR, Munich
Registry updated 2026-08-28
NCT03320304
A Study to Assess Effectiveness and Efficiency of VNS Therapy in Patients With Difficult to Treat Depression.
Research · LivaNova
Sozialstiftung Bamberg Klinikum am Bruderwald, Bamberg · Universitätsklinikum Bonn, Bonn · Universitätsklinikum Köln, Cologne · LVR-Hospital Essen, Essen · Universitätsklinikum Frankfurt, Frankfurt · Universitätsklinikum Freiburg, Freiburg im Breisgau · Universitätsmedizin Göttingen, Göttingen · Medizinische Hochschule Hannover, Hanover · Universitätsklinikum Jena, Jena · Universitätsklinik Leipzig, Leipzig · University Hospital Munster, Münster · Klinikum Wilhelmshaven, Wilhelmshaven
Registry updated 2026-08-27
NCT07444242
Accelerated Treatment of Depressive Patients With tDCS
Trial Treatment · University of Regensburg
Psychiatry and Psychotherapy, Center of Neuromodulation / TMS, University Regensburg, Regensburg
Registry updated 2026-06-15
NCT04996433
A Comparison of Two Psychotherapy Programs in Persistently Depressed Treatment-Resistant Inpatients
Trial Treatment · University of Greifswald
Charité - University Medicine Berlin, Berlin · Universitätsklinikum Bonn, Bonn · Medizinische Hochschule Hannover, Hanover · Universitätsklinikum Jena, Jena · Universität zu Lübeck, Lübeck · Universitätsklinikum Marburg, Marburg · Klinikum der Universität München, München · Universitätsklinikum Tübingen, Tübingen
Registry updated 2026-05-26
NCT07586150
Personalized Pharmaco-Lifestyle Interventions for Severe Mental Illnesses (LIFETRAIN)
Trial Treatment · Ludwig-Maximilians - University of Munich
Central Institute of Mental Health, Mannheim · Department of Psychiatry and Psychotherapy, LMU Klinikum, München
Registry updated 2026-05-14
NCT06130371
Stress, Inflammation and Neuroimaging in Major Depressive Disorder as Compared to Premenstrual Dysphoric Disorder
Research · University Hospital Tuebingen
University Hospital Tübingen, Klinik für Psychiatrie und Psychotherapie, Tübingen
Registry updated 2026-04-07
NCT07488910
Dynamic Networks in Depression Treatment: Mechanisms of Change in Pharmacological, Psychological and Combined Treatment of Depression
Trial Treatment · Phase 4 · Goethe University
Clinical Psychology and Psychotherapy, Frankfurt · Department of Psychiatry, Psychosomatics and Psychotherapy, Frankfurt · Department of Psychiatry and Psychotherapy, Marburg
Registry updated 2026-03-23
NCT05909267
Dopamine Modulation of Motivation and Motor Function in Major Depression & Inflammation
Trial Treatment · Charite University, Berlin, Germany
Klinik für Psychiatrie und Psychotherapie, Steglitz
Registry updated 2026-03-18
NCT07402356
VR Pupillometry in Cognitive Impairment
Research · Max-Planck-Institute of Psychiatry
Max Planck Institute of Psychiatry, München
Registry updated 2026-02-17
NCT07388004
Group Therapy for Major Depression: Comparing Expectation-Focused and Reward-Focused Psychotherapy Approaches
Trial Treatment · Philipps University Marburg
Philipps University Marburg, Marburg
Registry updated 2026-02-10
NCT06919133
The Effect of Digital Markers in the Self-management of Depressive Symptoms
Trial Treatment · Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Frankfurt University Hospital, Frankfurt
Registry updated 2026-01-14
NCT07198100
tVNS, Motivation, and Insulin Sensitivity
Trial Treatment · University of Bonn
Section of Medical Psychology, Department of Psychiatry & Psychotherapy, Faculty of Medicine, University of Bonn, Bonn
Registry updated 2025-12-24
NCT05570110
Enoxolone in Major Depression - Biomarker-outcome Relationship
Trial Treatment · Phase 1/2 · Philipps University Marburg
Clinic for Psychiatry and Psychotherapy, Marburg
Registry updated 2025-12-08

All Depression trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

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