Depression trials in United Kingdom

In United Kingdom 26 Also abroad 666

26 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 2Not yet taking people in United Kingdom
A Study of Brenipatide in Participants With Major Depressive Disorder
Where
Doncaster, Exeter, London
Age
18 years to 75 years
People
330 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07928245 · EU 2026-527689-65-00
No phaseTaking people
PROMOTE: Effects of 5-HT4 Agonism on Cognition and Sleep in Peopl With Low Mood
Where
Oxford
Age
18 years to 65 years
People
60
Run by
University of Oxford
See details and how to joinNCT07848477
Phase 3Taking people
A Study of Brenipatide in Adult Participants With Major Depressive Disorder
Where
Edinburgh, Exeter, Glasgow, London, Nottingham, Oxford, Penzance, Rotherham
Age
18 years to 75 years
People
1,000 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07412756 · EU 2025-522308-25-00
No phaseTaking people
Mechanisms of Repeated Real-time Biofeedback With 7-Tesla MRI in Depression
Where
Oxford
Age
18 years to 65 years
People
60
Run by
University of Oxford
See details and how to joinNCT07694076
Phase 3Taking people
A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder
Where
Bodmin, Edinburgh, Exeter, Glasgow, Liverpool, Motherwell, Oxford, Penzance, Reading, Rotherham
Age
18 years to 75 years
People
1,000 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07775300 · EU 2025-522310-24-00
Phase 3Taking people
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
Where
Cambridge, Doncaster, Edinburgh, Glasgow, Liverpool, London, Newcastle upon Tyne, Reading, Sheffield
Age
18 years to 85 years
People
330 worldwide
Run by
Cybin IRL Limited
See details and how to joinNCT06793397 · EU 2024-519270-40-00
Phase 3Taking people
Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
Where
London, Manchester, Sheffield, Southampton
Age
18 years and over
People
850 worldwide
Run by
Neurocrine Biosciences
See details and how to joinNCT06966401 · EU 2024-519423-24-00
Phase 2Taking people
ALTO-207 in Adults With Treatment-resistant Depression (TRD)
Where
Antrim, Birmingham, Bristol, Cardiff, Exeter, London, Nottingham, Oxford, Prescot, Sheffield
Age
18 years to 75 years
People
178 worldwide
Run by
Alto Neuroscience
See details and how to joinNCT07553637
No phaseNot yet taking people in United Kingdom
Dual Neuromodulation for Depression: Boosting TMS With tES
Where
Liverpool
Age
18 years to 59 years
People
60
Run by
Mersey Care NHS Trust
See details and how to joinNCT07879924
No phaseNot yet taking people in United Kingdom
Prescribing the Right Agent for Depression in Adults
Where
Oxford
Age
18 years to 74 years
People
2,142 worldwide
Run by
University of Oxford
See details and how to joinNCT07796295
Phase 2Taking people
A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression
Where
Chester, Eastbourne, Glasgow, London, Nottingham, Oxford
Age
18 years to 75 years
People
300 worldwide
Run by
Draig Therapeutics Ltd
See details and how to joinNCT07300969
No phaseNot yet taking people in United Kingdom
Individual Narratives of Stimulation (ECT and TMS)
Where
Liverpool, Nottingham
Age
18 years and over
People
12
Run by
University of Nottingham
See details and how to joinNCT07807930
Phase 3Enrolling by invitation
Phase III Long-term Extension Trial to Assess Safety and Efficacy of CYB003 in MDD (EXTEND)
Where
Reading
Age
18 years to 85 years
People
468 worldwide
Run by
Cybin IRL Limited
See details and how to joinNCT06605105 · EU 2024-516805-22-00
No phaseTaking people
A Study to Assess Effectiveness and Efficiency of VNS Therapy in Patients With Difficult to Treat Depression.
Where
Leicester, London, Newcastle upon Tyne, Wells
Age
18 years and over
People
500 worldwide
Run by
LivaNova
See details and how to joinNCT03320304
Phase 3Taking people
NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
Where
London, Salford, Sheffield, Southampton
Age
18 years and over
People
200 worldwide
Run by
Neurocrine Biosciences
See details and how to joinNCT06963021 · EU 2024-519421-37-00
Phase 2Taking people
An Open-Label Study to Evaluate the Safety, Tolerability and Pharmacodynamics of BPL-003 in Patients With Treatment Resistant Depression
Where
Liverpool, London
Age
18 years to 75 years
People
72
Run by
Beckley Psytech Limited
See details and how to joinNCT05660642
No phaseNot yet taking people in United Kingdom
Using Fenfluramine to Test the Serotonin Deficiency Theory of Depression
Where
London
Age
21 years and over
People
46
Run by
Imperial College Healthcare NHS Trust
See details and how to joinNCT07651293
Phase 4Taking people
Clinical Study Evaluating Pharmacogenomics-informed Pharmacotherapy Versus Dosing as Usual in Psychiatric Disorders
Where
London
Age
16 years to 70 years
People
2,500 worldwide
Run by
Parnassia Groep
See details and how to joinNCT05656469 · EU 2023-509680-25-00
No phaseTaking people
Home-Based Transcranial Direct Current Stimulation In Major Depressive Disorder (HOME)
Where
Cardiff, London, Newcastle, Northampton, Nottingham, Southampton
Age
18 years and over
People
438
Run by
King's College London
See details and how to joinNCT07228468
No phaseTaking people
Comorbid Obesity and Depression With an Anti-inflammatory Medication
Where
London
Age
18 years to 65 years
People
35
Run by
King's College London
See details and how to joinNCT06537921
No phaseNot yet taking people in United Kingdom
Mental Health Mission Mood Disorder Cohort Study
Where
Oxford
Age
18 years and over
People
2,000
Run by
University of Oxford
See details and how to joinNCT07189689
Phase 3Taking people
The Effect of a Six Week Intensified Pharmacological Treatment for Bipolar Depression Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.
Where
London
Age
18 years and over
People
418 worldwide
Run by
Dr. Inge Winter
See details and how to joinNCT05973786 · EU 2023-506605-19-00
Phase 3Taking people
The Effect of a Six Week Intensified Pharmacological Treatment for Major Depressive Disorder Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.
Where
London
Age
18 years to 65 years
People
418 worldwide
Run by
Dr. Inge Winter
See details and how to joinNCT05973851 · EU 2023-506617-21-00
No phaseTaking people
Investigating the Impacts of Early Life Experience on the Brain & Behaviour
Where
Manchester
Age
18 years to 25 years
People
120
Run by
University of Manchester
See details and how to joinNCT06823492
No phaseEnrolling by invitation
Evaluating the Effectiveness and Acceptability of a GPT-4o and RAG-Based Voice Chatbot for Depression Screening Using PHQ-9
Where
London
Age
18 years to 65 years
People
100
Run by
University College, London
See details and how to joinNCT06801925