Depression: open trials in United States

219 open trials have a site in United States. Registry data; only the trial team decides who can take part.

NCT06462196
Natural History of Depression, Bipolar Disorder and Suicide Risk
Research · National Institute of Mental Health (NIMH)
National Institutes of Health Clinical Center, Bethesda
Registry updated 2026-11-03
NCT06559306
Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms
Trial Treatment · Phase 3 · Janssen Research & Development, LLC
PAMOJA Clinical Institute LLC, Anaheim · Agile Clinical Research Trials, LLC, Atlanta · Advanced Discovery Research, Atlanta · BioBehavioral Research of Austin PC, Austin · The University of Texas at Austin, Austin · Haidar Almhana Nieding, Avon Lake · Houston Clinical Trials, LLC, Bellaire · University of Alabama at Birmingham, Birmingham · Boston Clinical Trials, Boston · Clinical Research of Brandon, Brandon · SPRI Clinical Trials, LLC, Brooklyn · Integrative Clinical Trials, LLC, Brooklyn · SanRo Clinical Research Group LLC WCG Clinical Network, Bryant · University at Buffalo Psychiatry, Buffalo · Chandler Clinical Trials, Chandler · Medical University of South Carolina, Charleston · Clinical Trials of South Carolina, Charleston · MetroMed Clinical Research, Chicago · Northwestern University, Chicago · University of Chicago Medical Center, Chicago · University of Cincinnati College of Medicine, Cincinnati · Patient Priority Clinical Sites LLC, Cincinnati · Axiom Research, Colton · The Ohio State University, Columbus · Relaro Medical Trials, Dallas · iResearch Atlanta, LLC, Decatur · Mountain View Clinical Research, Denver · Cedar Clinical Research, Draper · Peachford Hospital-Atlanta Behavorial Research, Dunwoody · Conrad Clinical Research, Edmond · Revive Research Institute, Elgin · Elite Research Network 6, Encino · Core Clinical Research, Everett · UConn Health Center, Farmington · North Texas Clinical Trials, Fort Worth · VAST Clinical Research, Garland · Behavioral Research Specialists, LLC, Glendale · AGA Clinical Trials, Hialeah · Reliable Clinical Research, Hialeah · IMA Clinical Research PC 3, Hickory · Advanced Research Institute of Miami, Homestead · Baylor College of Medicine, Houston · DM Clinical Research, Houston · Clinical NeuroScience Solutions Inc, Jacksonville · Multi-Specialty Research Associates, Inc., Lake City · Alcanza Clinical Research, Largo · Redbird Research, Las Vegas · Oasis Clinical Research LLC, Las Vegas · Preferred Research Partners, Little Rock · WR PRI Los Alamitos, Los Alamitos · Mankato Clinic, Mankato · Nuovida Research Center, Miami · Miami Dade Medical Research Institute, Miami · Pharmax Research Clinic Inc, Miami · North Star Medical Research, Middleburg Heights · Bioscience Research LLC, Mount Kisco · Baber Research Group, Naperville · Aqualane Clinical Research, Naples · Fieve Clinical Research, Inc, New York · Hapworth Psychiatric Medical PLLC, New York · Bravo Health Care Center, North Bay Village · Excell Research, Inc., Oceanside · Nova Psychiatry Inc., Orlando · University of Pennsylvania, Philadelphia · ActivMed Practices and Research, Portsmouth · Prospective Research Innovations Inc, Rancho Cucamonga · Anderson Clinical Research, Redlands · Florida Center for TMS, Saint Augustine · Lumos Clinical Research Center LLC, San Jose · Syrentis Clinical Research, Santa Ana · iResearch Savannah, Savannah · California Neuroscience Research, Sherman Oaks · Renew Health Clinical Research, Snellville · Accelerated Clinical Research Group LLC, Snellville · R and H Clinical Research, Stafford · University of South Florida, Tampa · Interventional Psychiatry of Tampa Bay, Tampa · Psych Me Medical Research Inc, Tampa · University of Arizona, Tucson · Adams Clinical LLC, Watertown · Health Synergy Clinical Research, West Palm Beach · Grayline Research Center, Wichita Falls · Conquest Research, Winter Park · Lucian Miron Manu MD Psychiatry PC, Woodbury
Registry updated 2026-11-03
NCT07503002
Shortened LSD Intervention for Major Depressive Disorder
Trial Treatment · Phase 1 · Johns Hopkins University
Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore
Registry updated 2026-11-03
NCT07716098
A Study of Esketamine Nasal Spray Versus Placebo Spray in Adult Participants With Treatment-resistant Depression
Trial Treatment · Phase 3 · Janssen Research & Development, LLC
Northwest Clinical Research Center, Bellevue · American Family Research Group, Cape Coral · Neurobehavioral Research, Inc., Cedarhurst · Ohio State University, Columbus · University of Connecticut Health Center, Farmington · Psych Atlanta, P.C., Marietta · Pharmax Research Clinic Inc, Miami · The Medical Research Network, LLC, New York · Charter Research - Orlando, Orlando · Anderson Clinical Research, Redlands · Midwest Research Group, Saint Maries · Artemis Institute for Clinical Research, San Diego · Psychiatric Medicine Associates, LLC, Skokie · Accelerated Clinical Research Group LLC, Snellville · Adams Clinical Watertown, Watertown
Registry updated 2026-11-03
NCT07775300
A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder
Trial Treatment · Phase 3 · Eli Lilly and Company
JEM Research Institute, Atlantis · FutureSearch Trials of Neurology, Austin · Pharmasite Research, Inc., Baltimore · Gadolin Research, Beaumont · Northwest Clinical Research Center, Bellevue · University of Alabama at Birmingham School of Medicine, Birmingham · Adams Clinical Boston, Boston · Bradenton Research Center, Inc., Bradenton · Key Clinical Research, Bradenton · Charter Research Chicago, Chicago · CenExel iResearch, LLC, Decatur · Adams Clinical Dallas, DeSoto · The University of Texas Rio Grande Valley, Harlingen · NextPhase Research Florida - Hollywood, Hollywood · Irvine Clinical Research, Irvine · Olympus Clinical Research, Katy · Healthy Brain Clinic, Long Beach · Diverse Clinical Research, Miami · Miami Jewish Health, Miami · Quantix Research - Miami - Southwest 72nd Street, Miami · CLA Research, Naples · Oakland Clinical, Oakland · Be Well Clinical Studies - Omaha, Omaha · Adams Clinical Philadelphia, Philadelphia · Penn Medicine: University of Pennsylvania Health System, Philadelphia · NoesisPharma, LLC, Phoenix · Boeson Research - Provo, Provo · AGILE Clinical Research Trials, LLC, Sandy Springs · Adams Clinical Bronx, The Bronx · Arcturus Healthcare , PLC, Troy Internal Medicine Research Division, Troy · Concierge Clinical Trials, Valley Village · Adams Clinical Watertown, Watertown · Suburban Research Associates, West Chester · Health Synergy Clinical Research, West Palm Beach
Registry updated 2026-11-03
NCT07862205
EEG-Guided Transcranial Magnetic Stimulation for Adults With Depression
Trial Treatment · Mayo Clinic
Mayo Clinic, Rochester
Registry updated 2026-11-03
NCT06793397
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
Trial Treatment · Phase 3 · Cybin IRL Limited
Emory University Dept of Psychiatry and Behavioral Studies, Atlanta · Austin Clinical Trial Partners, Austin · Johns Hopkins Medicine, Baltimore · UAB, Psychiatry and Behavioral Neurology, Birmingham · Adams Clinical Boston, Boston · RUSH University, Chicago · Adams Clinical Dallas, DeSoto · Institute for Integrative Therapies, Eden Prairie · Core Clinical Research, Everett · North Texas Clinical Trials, Fort Worth · Lighthouse Psychiatry, Gilbert · Behavioral Research Specialists, LLC, Glendale · The Remedy Mental Health, Golden Valley · Brain Health Consultants and TMS Center, Houston · Sun Valley Research Center, Imperial · CNS Healthcare, Jacksonville · Redbird Research, LLC, Las Vegas · Pillar Clinical Research - Little Rock, Little Rock · Lipov Medical Group, Los Angeles · CalNeuro Research Group, Los Angeles · Accel Research Sites - Maitland, Maitland · Psych Atlanta, Marietta · Tandem Clinical Research, Marrero · Aqualane Clinical Research, Naples · Yale School of Medicine - Yale Program for Psychedelic Science, New Haven · Atlas Psychiatry, New Orleans · Adams Clinical Harlem, New York · New York State Psychiatric Institute, New York · SP Research PLLC, Oklahoma City · ATP Clinical Research, Orange · NRC Research Institute, Orange · Flourish Research - Philadelphia, Philadelphia · Adams Clinical Philadelphia, Philadelphia · Sunstone Medical, PC, Rockville · Flourish Research San Antonio, San Antonio · Inland Psychiatric Medical Group Inc (IPMG Research), San Juan Capistrano · Psychedelic Science Institute, Santa Monica · Seattle Neuropsychiatric Treatment Center, Seattle · Stanford University, Stanford · K2 Medical Research - Tampa, Tampa · Adams Clinical Bronx, The Bronx · Bio Behavioral Health, Toms River · Adams Clinical Watertown, Watertown
Registry updated 2026-11-02
NCT06966401
Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
Trial Treatment · Phase 3 · Neurocrine Biosciences
Neurocrine Clinical Site, Atlanta · Neurocrine Clinical Site, Avon Lake · Neurocrine Clinical Site, Bellaire · Neurocrine Clinical Site, Boston · Neurocrine Clinical Site, Bryant · Neurocrine Clinical Site, Cedarhurst · Neurocrine Clinical Site, Chino · Neurocrine Clinical Site, Cromwell · Neurocrine Clinical Site, Dallas · Neurocrine Clinical Site, DeSoto · Neurocrine Clinical Site, Draper · Neurocrine Clinical Site, Edmond · Neurocrine Clinical Site, Farmington · Neurocrine Clinical Site, Gaithersburg · Neurocrine Clinical Site, Glendale · Neurocrine Clinical Site, Hollywood · Neurocrine Clinical Site, Houston · Neurocrine Clinical Site, Huntsville · Neurocrine Clinical Site, Irvine · Neurocrine Clinical Site, Little Rock · Neurocrine Clinical Site, Los Angeles · Neurocrine Clinical Site, Maitland · Neurocrine Clinical Site, Miami · Neurocrine Clinical Site, Miami Gardens · Neurocrine Clinical Site, Mount Kisco · Neurocrine Clinical Site, New York · Neurocrine Clinical Site, Oceanside · Neurocrine Clinical Site, O'Fallon · Neurocrine Clinical Site, Oklahoma City · Neurocrine Clinical Site, Orange · Neurocrine Clinical Site, Orlando · Neurocrine Clinical Site, Palm Bay · Neurocrine Clinical Site, Philadelphia · Neurocrine Clinical Site, Pico Rivera · Neurocrine Clinical Site, Richmond · Neurocrine Clinical Site, Saint Charles · Neurocrine Clinical Site, San Diego · Neurocrine Clinical Site, San Francisco · Neurocrine Clinical Site, San Jose · Neurocrine Clinical Site, Stafford · Neurocrine Clinical Site, Tampa · Neurocrine Clinical Site, The Bronx · Neurocrine Clinical Site, The Woodlands · Neurocrine Clinical Site, Upland · Neurocrine Clinical Site, Watertown
Registry updated 2026-11-02
NCT07310381
Vagus Nerve Stimulation (VNS) Electroencephalogram (EEG) Protocol Supplement
Trial Treatment · Stanford University
Department of Psychiatry and Behavioral Sciences, Stanford School of Medicine, Stanford
Registry updated 2026-11-02
NCT07594483
Regulated Stimulation for Optimized Network Activity and Therapeutic Equilibrium
Trial Treatment · Motif Neurotech, Inc.
Emory Healthcare, Atlanta · UTHealth Houston, Houston · Brain Health Consultants and TMS Center, Houston · University of Iowa, Iowa City
Registry updated 2026-11-02
NCT03973268
Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression
Trial Treatment · Phase 1 · National Institute of Mental Health (NIMH)
National Institutes of Health Clinical Center, Bethesda
Registry updated 2026-10-30
NCT06442423
Open-Label Psilocybin Study in Transdiagnostic Population
Trial Treatment · Phase 1 · Yale University
Connecticut Mental Health Center - Yale School of Medicine, New Haven
Registry updated 2026-10-30
NCT07593222
Synaptic Mechanisms of Intermittent Theta Burst Stimulation for Major Depressive Disorder
Trial Treatment · Phase 1/2 · Mclean Hospital
McLean Hospital, Belmont
Registry updated 2026-10-30
NCT07621237
A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)
Trial Treatment · Phase 2 · Tonix Pharmaceuticals, Inc.
Clinical Research Site, Austin · Clinical Research Site, Buena Park · Clinical Research Site, Chicago · Clinical Research Site, Chino · Clinical Research Site, Dallas · Clinical Research Site, Jacksonville · Clinical Research Site, Las Vegas · Clinical Research Site, Lemon Grove · Clinical Research Site, Maitland · Clinical Research Site, McKinney · Clinical Research Site, Mephis · Clinical Research Site, Methuen · Clinical Research Site, Miami · Clinical Research Site, New Orleans · Clinical Research Site, New York · Clinical Research Site, Norcross · Clinical Research Site, North Charleston · Clinical Research Site, Orange · Clinical Research Site, Orange City · Clinical Research Site, Orlando · Clinical Research Site, Phoenix · Clinical Research Site, Plano · Clinical Research Site, Provo · Clinical Research Site, Rockville · Clinical Research Site, San Diego · Clinical Research Site, Tampa · Clinical Research Site, Walnut Creek
Registry updated 2026-10-30
NCT07785102
Single Day of Ultra-accelerated TMS With a Single Dose of NRX-101
Trial Treatment · Early phase 1 · Mclean Hospital
McLean Hospital, Belmont
Registry updated 2026-10-30
NCT03065335
Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder
Trial Treatment · Phase 1 · National Institute of Mental Health (NIMH)
National Institutes of Health Clinical Center, Bethesda
Registry updated 2026-10-29
NCT06511544
rTMS to Target Neural Connectivity and Rumination in Treatment-Resistant Depression
Trial Treatment · Indiana University
Goodman Hall Neuroscience Center, Indianapolis
Registry updated 2026-10-28
NCT07130734
Digital Intervention for Physical Activity
Trial Treatment · Auburn University
Kinesiology Building, Auburn
Registry updated 2026-10-28
NCT07876908
SAINT® Therapy for Memory Problems in Older Adults With Treatment-Resistant Depression
Trial Treatment · BrainHealth Solutions, Inc.
BrainHealth Solutions Inc., Costa Mesa
Registry updated 2026-10-28
NCT06136546
Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via Infliximab
Trial Treatment · Phase 2 · Massachusetts General Hospital
Massachusetts General Hospital, Boston
Registry updated 2026-10-27
NCT07896343
Understanding the Neural Underpinnings of Risk-Taking Behavior in Psychiatric Disease
Trial Treatment · University of California, San Francisco
UCSF, San Francisco
Registry updated 2026-10-27
NCT03388606
Characterization and Treatment of Adolescent Depression
Research · National Institute of Mental Health (NIMH)
National Institutes of Health Clinical Center, Bethesda · University of Colorado, Denver · University of Southern California, Los Angeles
Registry updated 2026-10-26
NCT05922878
Study of ALTO-300 in MDD
Trial Treatment · Phase 2 · Alto Neuroscience
Site 114, Albuquerque · Site 216, Allentown · Site 316, Austin · Site 218, Bellflower · Site 317, Blackfoot · Site 119, Boise · Site 236, Boise · Site 318, Carlsbad · Site 310, Chicago · Site 202, Cincinnati · Site 159, Clermont · Site 207, Clinton · Site 203, Colorado Springs · Site 239, Conroe · Site 229, Creve Couer · Site 102, Dallas · Site 343, Denver · Site 345, Evergreen · Site 349, Evergreen · Site 277, Fairfax · Site 238, Fayetteville · Site 347, Fort Worth · Site 148, Fort Worth · Site 217, Glendale · Site 279, Hattiesburg · Site 199, Hickory · Site 275, Houston · Site 320, Houston · Site 215, Jackson · Site 335, Lafayette · Site 344, Las Vegas · Site 209, Los Angeles · Site 240, Mankato · Site 201, Marrero · Site 219, Mather · Site 350, Media · Site 225, Miami Gardens · Site 190, Miami Lakes · Site 265, Minneapolis · Site 194, Mission Viejo · Site 206, Missouri City · Site 198, Monroe · Site 267, Moorpark · Site 352, Moosic · Site 283, New York · Site 319, New York · Site 214, Norwalk · Site 161, Okeechobee · Site 303, Oklahoma City · Site 195, Oklahoma City · Site 231, Omaha · Site 189, Phoenix · Site 200, Phoenix · Site 353, Plano · Site 315, Provo · Site 196, Richmond · Site 211, Roanoke · Site 191, Rochester · Site 193, Rogers · Site 287, Rose Hill · Site 234, San Marcos · Site 224, Savannah · Site 208, Snellville · Site 192, Staten Island · Site 235, Stephenville · Site 264, St Louis · Site 293, Stone Mountain · Site 221, Tampa · Site 197, Temecula · Site 220, West Palm Beach · Site 314, Wichita · Site 268, Winston-Salem · Site 288, Worcester · Site 187, Yuma
Registry updated 2026-10-26
NCT07553637
ALTO-207 in Adults With Treatment-resistant Depression (TRD)
Trial Treatment · Phase 2 · Alto Neuroscience
Site 7148, Albany · Site 7170, Amherst · Site 7151, Annapolis · Site 7155, Ann Arbor · Site 7199, Austin · Site 7185, Baltimore · Site 7154, Bloomfield Hills · Site 7190, Bryan · Site 7127, Cary · Site 7055, Cedarhurst · Site 7143, Charlotte · Site 7153, Chino · Site 7029, Cincinnati · Site 7176, Dallas · Site 7194, Dayton · Site 7173, Dothan · Site 7172, East Providence · Site 7177, Fairfax · Site 7160, Fort Worth · Site 7150, Galveston · Site 7158, Garfield Heights · Site 7178, Grand Rapids · Site 7145, Houston · Site 7175, Houston · Site 7169, Indianapolis · Site 7161, Irving · Site 7195, La Jolla · Site 7162, Lewiston · Site 7069, Los Angeles · Site 7146, Marietta · Site 7192, Naperville · Site 7191, North Myrtle Beach · Site 7156, Oakland · Site 7082, Oceanside · Site 7159, Palo Alto · Site 7000, Phoenix · Site 7054, Pikesville · Site 7186, Plano · Site 7180, Rockville · Site 7016, Sacramento · Site 7152, Saint Augustine · Site 7144, San Diego · Site 7120, San Jose · Site 7141, Savannah · Site 7128, Seattle · Site 7064, Snellville · Site 7163, South Charleston · Site 7189, St Louis · Site 7157, Syracuse · Site 7066, Toms River · Site 7171, Valley Village · Site 7200, Wilton · Site 7166, Worcester
Registry updated 2026-10-26
NCT07895134
Psilocybin for Depression in Veterans
Trial Treatment · Phase 2 · VA Office of Research and Development
Minneapolis VA Health Care System, Minneapolis, MN, Minneapolis · VA Salt Lake City Health Care System, Salt Lake City, UT, Salt Lake City · VA San Diego Healthcare System, San Diego, CA, San Diego · San Francisco VA Medical Center, San Francisco, CA, San Francisco
Registry updated 2026-10-26

All Depression trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

Report an error