Depression: open trials in United States

• NCT07908563

  Dupilumab in Major Depressive Disorder

  Trial Treatment · Phase 2 · Icahn School of Medicine at Mount Sinai

  The Dennis S. Charney, MD, Depression and Anxiety Discovery Center, New York

  Registry updated 2026-11-02

• NCT03973268

  Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression

  Trial Treatment · Phase 1 · National Institute of Mental Health (NIMH)

  National Institutes of Health Clinical Center, Bethesda

  Registry updated 2026-10-30

• NCT06442423

  Open-Label Psilocybin Study in Transdiagnostic Population

  Trial Treatment · Phase 1 · Yale University

  Connecticut Mental Health Center - Yale School of Medicine, New Haven

  Registry updated 2026-10-30

• NCT07593222

  Synaptic Mechanisms of Intermittent Theta Burst Stimulation for Major Depressive Disorder

  Trial Treatment · Phase 1/2 · Mclean Hospital

  McLean Hospital, Belmont

  Registry updated 2026-10-30

• NCT07621237

  A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)

  Trial Treatment · Phase 2 · Tonix Pharmaceuticals, Inc.

  Austin · Buena Park · Chicago · Chino · Dallas · Jacksonville · Las Vegas · Lemon Grove · Maitland · McKinney · Mephis · Methuen · Miami · New Orleans · New York · Norcross · North Charleston · Orange · Orange City · Orlando · Phoenix · Plano · Provo · Rockville · San Diego · Tampa · Walnut Creek

  Registry updated 2026-10-30

• NCT07785102

  Single Day of Ultra-accelerated TMS With a Single Dose of NRX-101

  Trial Treatment · Early phase 1 · Mclean Hospital

  McLean Hospital, Belmont

  Registry updated 2026-10-30

• NCT03065335

  Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder

  Trial Treatment · Phase 1 · National Institute of Mental Health (NIMH)

  National Institutes of Health Clinical Center, Bethesda

  Registry updated 2026-10-29

• NCT07130734

  Digital Intervention for Physical Activity

  Trial Treatment · Auburn University

  Kinesiology Building, Auburn

  Registry updated 2026-10-28

• NCT07226661

  Double-blind, Placebo-controlled Study in Adults With Major Depressive Disorder

  Trial Treatment · Phase 2 · Supernus Pharmaceuticals, Inc.

  Cenexel Atlanta (ACMR), Atlanta · Houston Clinical Trials, Bellaire · University of Alabama, Birmingham · SPRI Clinical Trials, Brooklyn · New Hope Clinical Research, Charlotte · Inland Psychiatric Medical Group., Chino · Alpine Research Organization, Clinton · CT Clinical Research, Cromwell · CenExel - iResearch Atlanta, Decatur · Mountain View Clinical Research, Denver · Leading Edge Research (Eximia Network), Encino · Core Clinical Research, Everett · Precise Clinical Research, Flowood · Cenexel Collaborative Neuroscience Network, Garden Grove · DM Clinical, Houston · Baylor College of Medicine, Houston · CNS Healthcare - Jacksonville, Jacksonville · Vector Clinical Trials, Las Vegas · Synergy Research (ERG Network), Lemon Grove · Cenexel Marlton (HRI), Marlton · Avantis Clinical Research, Miami · Catalina Research Institute (Elixia), Montclair · Manhattan Behavioral Medicine, New York · Psychiatric Care and Research Center, O'Fallon · Paradigm Research Professionals, Oklahoma City · ATP Clinical Research, Orange · NRC Research Institute, Orange · CNS Healthcare of Orlando, Orlando · Space Coast Neuropsychiatric Research Institute, Palm Bay · IMA Clinical Research Phoenix, Phoenix · Summit Headlands (Headlands Research), Portland · Woodland Research Northwest (ERG), Rogers · Midwest Research Group, Saint Charles · Aura Wellness, Salt Lake City · Lumos Clinical Research Center, San Jose · Cenexel Tampa, Tampa · Interventional Psychiatry of Tampa Bay, Tampa · Inland Psychiatric Medical Group, Temecula · AMR Conventions Research, Warrenville · Grayline Research Center, Wichita Falls

  Registry updated 2026-10-28

• NCT07876908

  SAINT® Therapy for Memory Problems in Older Adults With Treatment-Resistant Depression

  Trial Treatment · BrainHealth Solutions, Inc.

  BrainHealth Solutions Inc., Costa Mesa

  Registry updated 2026-10-28

• NCT07901179

  A Study to Evaluate the Safety and Efficacy of ALKS 7290 as an Adjunctive Therapy to Antidepressants in Adult Participants With Major Depressive Disorder

  Trial Treatment · Phase 2 · Alkermes, Inc.

  Jacksonville

  Registry updated 2026-10-28

• NCT04748276

  Tracking Response to Antidepressants in Advance of Investigational Trials

  Research · Adams Clinical

  Adams Clinical, Watertown

  Registry updated 2026-10-27

• NCT06136546

  Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via Infliximab

  Trial Treatment · Phase 2 · Massachusetts General Hospital

  Massachusetts General Hospital, Boston

  Registry updated 2026-10-27

• NCT07896343

  Understanding the Neural Underpinnings of Risk-Taking Behavior in Psychiatric Disease

  Trial Treatment · University of California, San Francisco

  UCSF, San Francisco

  Registry updated 2026-10-27

• NCT03388606

  Characterization and Treatment of Adolescent Depression

  Research · National Institute of Mental Health (NIMH)

  National Institutes of Health Clinical Center, Bethesda · University of Colorado, Denver · University of Southern California, Los Angeles

  Registry updated 2026-10-26

• NCT05922878

  Study of ALTO-300 in MDD

  Trial Treatment · Phase 2 · Alto Neuroscience

  Albuquerque · Allentown · Austin · Bellflower · Blackfoot · Boise · Boise · Carlsbad · Chicago · Cincinnati · Clermont · Clinton · Colorado Springs · Conroe · Creve Couer · Dallas · Denver · Evergreen · Evergreen · Fairfax · Fayetteville · Fort Worth · Fort Worth · Glendale · Hattiesburg · Hickory · Houston · Houston · Jackson · Lafayette · Las Vegas · Los Angeles · Mankato · Marrero · Mather · Media · Miami Gardens · Miami Lakes · Minneapolis · Mission Viejo · Missouri City · Monroe · Moorpark · Moosic · New York · New York · Norwalk · Okeechobee · Oklahoma City · Oklahoma City · Omaha · Phoenix · Phoenix · Plano · Provo · Richmond · Roanoke · Rochester · Rogers · Rose Hill · San Marcos · Savannah · Snellville · Staten Island · Stephenville · St Louis · Stone Mountain · Tampa · Temecula · West Palm Beach · Wichita · Winston-Salem · Worcester · Yuma

  Registry updated 2026-10-26

• NCT07553637

  ALTO-207 in Adults With Treatment-resistant Depression (TRD)

  Trial Treatment · Phase 2 · Alto Neuroscience

  Albany · Amherst · Annapolis · Ann Arbor · Austin · Baltimore · Bloomfield Hills · Bryan · Cary · Cedarhurst · Charlotte · Chino · Cincinnati · Dallas · Dayton · Dothan · East Providence · Fairfax · Fort Worth · Galveston · Garfield Heights · Grand Rapids · Houston · Houston · Indianapolis · Irving · La Jolla · Lewiston · Los Angeles · Marietta · Naperville · North Myrtle Beach · Oakland · Oceanside · Palo Alto · Phoenix · Pikesville · Plano · Rockville · Sacramento · Saint Augustine · San Diego · San Jose · Savannah · Seattle · Snellville · South Charleston · St Louis · Syracuse · Toms River · Valley Village · Wilton · Worcester

  Registry updated 2026-10-26

• NCT07895134

  Psilocybin for Depression in Veterans

  Trial Treatment · Phase 2 · VA Office of Research and Development

  Minneapolis VA Health Care System, Minneapolis, MN, Minneapolis · VA Salt Lake City Health Care System, Salt Lake City, UT, Salt Lake City · VA San Diego Healthcare System, San Diego, CA, San Diego · San Francisco VA Medical Center, San Francisco, CA, San Francisco

  Registry updated 2026-10-26

• NCT07226232

  Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression

  Trial Treatment · Phase 3 · VA Office of Research and Development

  Birmingham VA Medical Center, Birmingham, AL, Birmingham · Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, Philadelphia · VA Portland Health Care System, Portland, OR, Portland · VA Puget Sound Health Care System Seattle Division, Seattle, WA, Seattle · Tuscaloosa VA Medical Center, Tuscaloosa, AL, Tuscaloosa

  Registry updated 2026-10-23

• NCT07499583

  Psilocybin Assisted Psychotherapy for Treatment Resistant Depression and Co-occurring Substance Use Disorder

  Trial Treatment · Phase 1/2 · Indiana University

  Goodman Hall, Dept of Psychiatry, Indiana University, Indianapolis · The Stark Neuroscience Building (Goodman Hall), Indianapolis

  Registry updated 2026-10-23

• NCT07592689

  A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)

  Trial Treatment · Phase 3 · Definium Therapeutics US, Inc.

  CenExel - Atlanta Center for Medical Research, Atlanta · Austin Clinical Trial Partners, Austin · Memory Clinic, Inc., Bennington · Adams Clinical Watertown, Boston · Adams Clinical Boston, Boston · Uptown Research Institute, Chicago · Cleveland Clinic, Cleveland · CenExel - iResearch Atlanta, Decatur · Mountain View Clinical Research, Inc, Denver · Cedar Clinical Research, Draper · Clinical Neuroscience Solutions, LLC (Jacksonville), Jacksonville · Redbird Research, Las Vegas · Preferred Research Partners, Inc, Little Rock · K2 Medical Research - Maitland, Maitland · Adams Clinical Harlem, New York · Coastal Carolina Research, North Charleston · ATP Clinical Research Orange County, Orange · Inner Space Research, Orem · Charter Research, Orlando · Clinical Neuroscience Solutions, LLC (Orlando), Orlando · Adams Clinical Philadelphia, Philadelphia · Kadima Neuropsychiatry Institute, San Diego · UCSF Department of Neurology, San Francisco · Psychedelic Science Institute, Santa Monica · Cenexel Iresearch - Savannah, Savannah · Seattle Neuropsychiatric Treatment Center, Seattle · Arch Clinical Trials, LLC, St Louis · K2 Medical Research - Tampa, Tampa · VA Portland Healthcare System, Vancouver · Vitalix Clinical, Worcester

  Registry updated 2026-10-23

• NCT07891624

  Neural Mechanisms of Real-world Emotions and Internalizing

  Trial Treatment · University of Miami

  University of Miami, Coral Gables

  Registry updated 2026-10-23

• NCT07196501

  A Study to Evaluate the Maintenance Effect of Osavampator as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

  Trial Treatment · Phase 3 · Neurocrine Biosciences

  Albuquerque · Austin · Bellaire · Charlotte · Draper · Edmond · Friendswood · Glen Oaks · Iowa City · Marrero · Miami Gardens · New Haven · Oceanside · O'Fallon · Oklahoma City · Orange · Orlando · Palm Bay · Philadelphia · Roanoke · San Jose · Stafford · Tampa · Wichita Falls

  Registry updated 2026-10-22

• NCT07889908

  Testing a Non-Deceptive Placebo Intervention for Subclinical Depressive Symptoms

  Trial Treatment · Miami University

  Miami University, Department of Psychology, Oxford

  Registry updated 2026-10-22

• NCT07227103

  A Randomized, Double-Blind Controlled Comparison of NRX-101 vs. Placebo for Adults Being Treated With Robotic Transcranial Magnetic Stimulation for Treatment Resistant Depression: The SPARC-TMS Trial

  Trial Treatment · Phase 2/3 · NeuroRx, Inc.

  Harvard Mclean Hospital, Belmont · Sarasota · HOPE Accelerated Care, West Palm Beach

  Registry updated 2026-10-21

All Depression trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

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