Depression: open trials in United States

270 open trials have a site in United States. Registry data; only the trial team decides who can take part.

NCT05573074
Transcranial Near Infrared Radiation and Cerebral Blood Flow in Depression - R33
Trial Treatment · NYU Langone Health
Harvard Medical School, Boston · NYU Langone Health, New York · Nathan Kline Institute for Psychiatric Research, Orangeburg
Registry updated 2026-02-05
NCT04509102
Psychostimulant Augmentation of Repetitive TMS for the Treatment of Major Depressive Disorder
Trial Treatment · Early phase 1 · University of California, Los Angeles
UCLA Semel, Los Angeles
Registry updated 2026-02-03
NCT06805851
Impact of Depression on Thermoregulation
Research · Penn State University
Noll Laboratory, University Park
Registry updated 2026-02-03
NCT00762866
Psychiatric Genotype/Phenotype Project Repository
Research · Vanderbilt University
Vanderbilt University Medical Center, Nashville
Registry updated 2026-01-27
NCT07369115
Neurocircuitry Mechanisms and Efficacy of Lumateperone as Adjunctive Therapy for Major Depressive Disorder and History of Early Life Abuse
Trial Treatment · Phase 4 · University of Texas at Austin
Health Discovery Building, Austin
Registry updated 2026-01-27
NCT06633016
Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder (AMPLIFY)
Trial Treatment · Phase 2 · Autobahn Therapeutics, Inc.
Anaheim · Atlanta · Beachwood · Beaumont · Bellevue · Berlin · Birmingham · Boston · Brandon · Brooklyn · Brooklyn · Chandler · Cromwell · Decatur · Elgin · Encino · Encino · Fairfax · Glendale · Hialeah · Jacksonville · Lake City · Las Vegas · Long Beach · Los Alamitos · Miami · Miami · Miami Gardens · Newport Beach · New York · North Charleston · Oceanside · Oklahoma City · Orange · Orem · Orlando · Peachtree Corners · Phoenix · Rancho Cucamonga · Saint Charles · San Antonio · San Jose · Savannah · Sherman · Staten Island · Tampa · Tucson · Walnut Creek · Watertown · West Covina
Registry updated 2026-01-20
NCT07329153
Neuronavigated aiTBS for TRD
Trial Treatment · University of Texas Southwestern Medical Center
University of Texas Southwestern Medical Center, Dallas · Cornell University, New York · University of California at San Diego (UCSD), San Diego
Registry updated 2026-01-09
NCT07195721
The Effect of PROSE or Scleral Lenses on Mental Health
Research · Boston Sight
BostonSight, Needham
Registry updated 2026-01-05
NCT06700902
Taking Action for College Students
Trial Treatment · Temple University
Temple University, Philadelphia
Registry updated 2025-12-29
NCT03736538
Nitrous Oxide- Suicidal Ideation
Trial Treatment · Phase 1 · Washington University School of Medicine
Washington University School of Medicine, St Louis
Registry updated 2025-12-22
NCT05450432
Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With Depression
Trial Treatment · Phase 4 · Massachusetts General Hospital
Massachusetts General Hospital, Boston
Registry updated 2025-12-12
NCT06002100
Prediction of REsponse to Depression Interventions Using Clinical and TD-fNIRS Measurements
Research · Kernel
Seattle Neuropsychiatric Treatment Center, Bellevue · Metro Psychiatry Inc., Columbus · BrainHealth Solutions, Costa Mesa · Kadima Neuropsychiatry Institute, La Jolla · Kaizen Brain Center, LLC, La Jolla · Bespoke Treatment, Los Angeles · UCLA TMS, Los Angeles · Seattle Neuropsychiatric Treatment Center, Seattle · Acacia Clinics, Sunnyvale
Registry updated 2025-12-12
NCT07159061
Neurofeedback to Treat Depression - 2
Trial Treatment · University of Pennsylvania
Center for Neuromodulation in Depression and Stress, Philadelphia
Registry updated 2025-12-04
NCT04080778
Magnetic Seizure Therapy in Bipolar Depression (MST-BpD) and Treatment Resistant Depression (MST-TRD)
Trial Treatment · Joao L. DeQuevedo
The University of Texas Health Science Center at Houston, Houston
Registry updated 2025-12-03
NCT06132178
Psilocybin rTMS for Treatment Resistant Depression
Trial Treatment · Phase 2 · University of Texas at Austin
Health Discovery Building (HDB), 1601 Trinity St., Bldg B., Z0600, Austin
Registry updated 2025-11-26
NCT02434393
Characterizing Cognitive Decline in Late Life Depression: The ADNI Depression Project
Research · University of Southern California
University of Pittsburgh, Pittsburgh · University of California San Francisco, San Francisco
Registry updated 2025-11-25
NCT06091527
Treating Major Depression With Yoga Mono-therapy
Trial Treatment · University of California, San Francisco
Zuckerberg San Francisco General Hospital, San Francisco
Registry updated 2025-11-06
NCT05377177
Cortical Inhibition as a Biomarker of Response in a Comparison of Bilateral Versus Unilateral Accelerated Theta Burst Stimulation for Suicidal Ideation in Treatment-Resistant Depression -COMBAT-SI
Trial Treatment · University of California, San Diego
UCSD Interventional Psychiatry, San Diego
Registry updated 2025-11-05
NCT06610305
Ovarian Hormone Withdrawal, Anhedonia, and Reward Sensitivity in Women With Premenstrual Exacerbations of Depression
Trial Treatment · Phase 4 · University of North Carolina, Chapel Hill
University of North Carolina, Chapel Hill, Chapel Hill
Registry updated 2025-10-29
NCT06786624
Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
Trial Treatment · Phase 3 · Neurocrine Biosciences
Avon Lake · Boston · Dallas · Everett · Garden Grove · Hollywood · Houston · Little Rock · Maitland · Mount Kisco · Orange · Pico Rivera · Richmond · San Diego · The Woodlands · Upland · Watertown · Westlake
Registry updated 2025-10-29
NCT05418894
Mapping and Modulating the Spatiotemporal Dynamics of Socio-Affective Processing
Trial Treatment · Baylor College of Medicine
Baylor College of Medicine, Houston
Registry updated 2025-10-27
NCT06816329
Stress Dynamics and Familial Risk for Depression in Female Adolescents
Trial Treatment · Mclean Hospital
McLean Hospital, Belmont
Registry updated 2025-10-23
NCT05630963
Beyond Monoamines: The Role of the Nociceptin/Orphanin FQ Receptor in Major Depression
Research · Mclean Hospital
McLean Hospital, Belmont
Registry updated 2025-10-21
NCT06854224
Orexin Antagonism for Suicide Risk: A Proof-of-Concept Clinical Trial
Trial Treatment · Phase 2 · Marianne Goodman
James J. Peters Veterans Affairs Medical Center, The Bronx
Registry updated 2025-09-25
NCT06860724
Linking Affective Dynamics in Response to Daily Stress to Peripheral Vascular Function in Working Age Adults
Trial Treatment · University of Delaware
University of Delaware, Newark
Registry updated 2025-09-17

All Depression trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

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