Depression: open trials in United States

270 open trials have a site in United States. Registry data; only the trial team decides who can take part.

NCT06523439
Accelerated Intermittent Theta Burst in Treatment-Naive Adolescents
Trial Treatment · University of Texas at Austin
Dell Medical School at University of Texas at Austin, Austin
Registry updated 2026-08-19
NCT06898879
Enhancing Veteran-Clinical Collaboration in VA PRRCs
Trial Treatment · VA Office of Research and Development
New Mexico VA Health Care System, Albuquerque, NM, Albuquerque · VA San Diego Healthcare System, San Diego, CA, San Diego · VA Greater Los Angeles Healthcare System, West Los Angeles, CA, West Los Angeles
Registry updated 2026-08-19
NCT04582916
PET Imaging of Cyclooxygenase in Participants With Major Depressive Disorder (MDD)
Trial Treatment · Phase 1 · National Institute of Mental Health (NIMH)
National Institutes of Health Clinical Center, Bethesda
Registry updated 2026-08-18
NCT06976697
Home-Based tDCS Treatment Of Major Depressive Disorder
Trial Treatment · Sooma Medical Inc
Curavit Clinical Research (virtual study site), Boston
Registry updated 2026-08-14
NCT06247839
The Effects of Psilocybin on Self-Focus and Self-Related Processing in Major Depressive Disorder
Trial Treatment · Phase 3 · Sharmin Ghaznavi
Athinoula A. Martinos Center for Biomedical Imaging, Charlestown
Registry updated 2026-08-13
NCT05725239
taVNS or TMS or Both for Depression
Trial Treatment · Medical University of South Carolina
Medical University of South Carolina Institute of Psychiatry, Charleston
Registry updated 2026-08-12
NCT04556890
Pain and Major Depressive Disorder
Trial Treatment · University of California, Los Angeles
UCLA Semel Institute, Los Angeles
Registry updated 2026-08-11
NCT06911112
NBI-1065845-MDD3025: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
Trial Treatment · Phase 3 · Neurocrine Biosciences
Atlanta · Boston · Bryant · Charlottesville · DeSoto · Glendale · Hollywood · Huntsville · Irvine · Mason · Miami · New York · Redlands · Saint Charles · San Francisco · Tampa · The Bronx
Registry updated 2026-08-11
NCT07174557
Remote Evaluation and Alerting for Collaborative Health (REACH) in Depression
Trial Treatment · Dartmouth-Hitchcock Medical Center
Dartmouth College, Hanover · Dartmouth-Hitchcock Clinics, Lebanon
Registry updated 2026-08-11
NCT06400121
Apimostinel + Automated Neurocognitive Training for Depression
Trial Treatment · Phase 2 · Rebecca Price
Western Psychiatric Institute and Clinic, Pittsburgh
Registry updated 2026-08-10
NCT06963021
NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
Trial Treatment · Phase 3 · Neurocrine Biosciences
Aurora · Cedarhurst · Charlotte · Chino · Cromwell · Farmington · Gaithersburg · Los Angeles · Maitland · Miami · New York · Philadelphia · Stanford · Tampa
Registry updated 2026-08-10
NCT07251491
Psilocybin to Treat Depression in Spinal Cord Injury
Trial Treatment · Phase 1/2 · James J. Peters Veterans Affairs Medical Center
James J. Peters Department of Veterans Affairs Medical Center, The Bronx
Registry updated 2026-08-10
NCT05400382
Maternal Mindfulness: Depression and Postpartum Pain
Trial Treatment · University of Illinois at Urbana-Champaign
University of Illinois Urbana-Champaign, Champaign
Registry updated 2026-08-06
NCT07050355
Combining rTMS & Aerobic Exercise to Treat Depression and Improve Post-Stroke Walking
Trial Treatment · Medical University of South Carolina
Medical University of South Carolina, Charleston · Duke University School of Medicine, Durham
Registry updated 2026-08-04
NCT04004169
Closed-Loop Deep Brain Stimulation for Major Depression
Trial Treatment · Andrew Krystal
University of California San Francisco, San Francisco
Registry updated 2026-08-03
NCT06547489
Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder
Trial Treatment · Phase 2 · Syndeio Biosciences, Inc
Lehigh Center for Clinical Research, Allentown · Austin Clinical Trial Partners, Austin · Northwest Clinical Research Center, Bellevue · University of Alabama at Birmingham, Birmingham · Boston Clinical Trials, Boston · Neurobehavioral Research, Inc., Cedarhurst · MCB Clinical Research Centers, Inc., Colorado Springs · Mountain View Clinical Research, Denver · InSite Clinical Research, LLC, DeSoto · Revive Research Institute, Elgin · Wr- Pri, Llc, Encino · University of Connecticut School of Medicine Psychiatry Department, Farmington · Baylor College of Medicine, Psychiatry and Behavioral Sciences, Houston · University of Alabama at Birmingham-Huntsville, Huntsville · Insight Clinical Trials LLC, Independence · Irvine Clinical Research, Irvine · Clinical NeuroScience Solutions Inc, Jacksonville · Vector Clinical Trials, Las Vegas · CalNeuro Research Group, Los Angeles · Quantum Research Associates Corp., Louisville · D&H Pompano Research Center, LLC, Margate · Clinical Neuroscience Solutions, Inc., Memphis · Premier Clinical Research Institute Inc, Miami · Miami Dade Medical Research Institute, Miami · Sooner Clinical Research, Inc., Oklahoma City · Andes Clinical Research, Orem · Clinical Neuroscience Solutions, Inc., Orlando · Mayflower Clinical, Russells Mills · Clinical Trials of Texas LLC, San Antonio · CenExel iRS (iResearch Savannah), Savannah · Pacific Clinical Research Management Group LLC, Upland · Sunwise Clinical Research, Llc, Walnut Creek · KUMC-Wichita, Wichita · Grayline Research Center, Wichita Falls
Registry updated 2026-08-03
NCT06795451
Modulating Spinal Interoceptive Pathways to Evaluate Their Role and Therapeutic Potential in MDD Symptomatic Domains
Trial Treatment · Phase 1/2 · University of Cincinnati
Lindner Center of Hope, Mason
Registry updated 2026-08-03
NCT07139106
Understanding the Role of the Kappa Opioid Receptor in Ketamine's Attenuation of Suicidal Thoughts
Trial Treatment · Phase 4 · New York State Psychiatric Institute
New York State Psychiatric Institute, New York
Registry updated 2026-08-03
NCT05671419
Mindful Self-Compassion for Anxiety Disorders and Depression
Trial Treatment · Georgetown University
Georgetown University Medical Center, Washington D.C.
Registry updated 2026-07-29
NCT07115329
A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder
Trial Treatment · Phase 2 · Syndeio Biosciences, Inc
Lehigh Center for Clinical Research, Allentown · Synapsis Bio, Atascocita · Elevate Synapsis, LLC, Atascocita · Neurobehavioral Research, Inc., Cedarhurst · EmVenio Research, Chicago · Adams Clinical Dallas, DeSoto · Psychiatric Consultants, PC, Franklin · Insight Clinical Trials LLC, Independence · Clinical NeuroScience Solutions Inc, Jacksonville · Tandem Clinical Research, Metairie · Premier Clinical Research Institute Inc, Miami · Catalina Research Institute, LLC, Montclair · Scranton Medical Institute, LLC, Moosic · Aqualane Clinical Research, Naples · IMA Clinical Research - NYC Midtown, New York · IMA Clinical Research - NYC Uptown, New York · Excell Research, Inc., Oceanside · Adams Clinical, Philadelphia · NoesisPharma, LLC, Phoenix · UNC Health Rex, Raleigh · Anderson Clinical Research, Redlands · Equipath Health and Research Tampa Bay, Llc, Riverview · Rochester Center for Behavioral Medicine, Rochester Hills · Sunstone Therapies, Rockville · Studyops Inc, San Francisco · Lumos Clinical Research Center, San Jose · Denali Health Atlanta, LLC, Stone Mountain · Continental Clinical Solutions, Towson · Del Sol Research Management, Tucson · Sunwise Clinical Research, Walnut Creek · Neuroscience Research Institute, West Palm Beach · Vitalix Clinical, Worcester
Registry updated 2026-07-27
NCT07494305
Multicenter Study to Assess the Efficacy and Safety of LB-102 in the Treatment of Adult Patients With BP1MDE.
Trial Treatment · Phase 2 · LB Pharmaceuticals Inc.
Trialmed, Atlanta · Northwest Clinical Research Center, Bellevue · CenExel, Bellflower · Pillar Clinical Research, Bentonville · Neuro-Behavioral Clinical Research, Canton · Pillar Clinical Research, Chicago · ProScience Research Group, Culver City · Cenexel Decatur GA, Decatur · Adams Clinical, DeSoto · NSRT, Detroit · St. Jude Clinical Research, Doral · CenExel, Garden Grove · Cenexel Hollywood Florida, Hollywood · Redbird Research, Las Vegas · Synergy San Diego, Lemon Grove · Pillar Clinical Research, Little Rock · NRC Research Institute, Los Angeles · Innovative Clinical Research, Miami Lakes · Manhattan Behavioral Medicine, New York · NRC Research Institute, Orange · Adams Clinical, Philadelphia · Pillar Clinical Research, Richardson · Cenexel, Riverside · Arch Clinical Trials, St Louis · CenExel, Torrance · Health Synergy Clinical Research, West Palm Beach
Registry updated 2026-07-27
NCT07263022
Cognitive Strategies in Early Psychosis 2
Trial Treatment · Phase 3 · University of Minnesota
University of Minnesota, Minneapolis
Registry updated 2026-07-23
NCT07563868
Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant Depression
Trial Treatment · Massachusetts General Hospital
Massachusetts General Hospital's Depression and Clinical Research program, Boston · Massachusetts General Hospital, Boston
Registry updated 2026-07-23
NCT05977439
RECOVERS - Realigning Emotion and COgnition Via prEcision Regulation networkS
Trial Treatment · Medical University of South Carolina
Medical Univeristy of South Carolina, Charleston
Registry updated 2026-07-21
NCT07713849
Transition Care for FEP
Research · University of Chicago
University of Chicago Medical Center, Biological Science Division, Chicago · University of Chicago Ingalls Memorial Hospital, Harvey
Registry updated 2026-07-20

All Depression trials and the map

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