Diffuse large B-cell lymphoma trials in United States

In United States 131 Also abroad 346

131 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 1Taking people
SynKIR-310 for Relapsed/Refractory B-NHL
Where
Atlanta, Denver, Fairway, New Brunswick, Philadelphia
Age
18 years and over
People
36
Run by
Verismo Therapeutics
See details and how to joinNCT06544265
Phase 1Taking people
Anti-CD30 biAb-AATC in Patients With Relapsed/Refractory CD30 Positive Hematopoietic Malignancies
Where
Milwaukee
Age
18 years and over
People
42
Run by
Medical College of Wisconsin
See details and how to joinNCT05544968
Phase 1Taking people
This is a Phase 1 Trial of ZM008, an Anti-LLT1 Antibody, Used as Single Agent Followed by Combination Treatment With Toripalimab in Patients With Advanced Solid Tumors
Where
Austin, TX 78758, Boston, San Antonio
Age
18 years and over
People
100
Run by
Zumutor Biologics Inc.
See details and how to joinNCT06451497
Phase 1Taking people
A Study of NX-2127 in Adults With Relapsed/Refractory B-cell Malignancies
Where
Bethesda, Chicago, Cincinnati, Columbus, Dallas, Denver, Duarte, Houston, Miami Beach, Nashville, New York, Orange, Salt Lake City, San Francisco, Sarasota, Seattle
Age
18 years and over
People
248
Run by
Nurix Therapeutics, Inc.
See details and how to joinNCT04830137
Phase 1/2Taking people
Acalabrutinib Maintenance for the Treatment of Patients With Large B-cell Lymphoma
Where
Los Angeles, Oklahoma City, Sacramento
Age
18 years to 70 years
People
24
Run by
Jonsson Comprehensive Cancer Center
See details and how to joinNCT05256641
Phase 2Taking people
A Phase II Study of Glofitamab Plus Polatuzumab-R-CHP for Patients With High-risk Diffuse Large B-cell Lymphoma
Where
Boston, Miami
Age
18 years and over
People
41
Run by
Jennifer Crombie, MD
See details and how to joinNCT05800366
Phase 2Taking people
Pembro Plus CAR T-cell Therapy in R/R in PMBCL
Where
Boston, New York
Age
18 years and over
People
35
Run by
Jennifer Crombie, MD
See details and how to joinNCT05934448
Phase 2Taking people
Fecal Microbiome Transplant to Remodel Intestinal Microbiota for Patients With Relapsed or Refractory Lymphoma With Exposure to High-Risk Antibiotics Who Are Receiving Chimeric Antigen Receptor T Cells
Where
Duarte
Age
18 years and over
People
56
Run by
City of Hope Medical Center
See details and how to joinNCT07042438
Phase 2Taking people
Zanubrutinib and Lisocabtagene Maraleucel for the Treatment of Richter's Syndrome
Where
Columbus, New York, Salt Lake City
Age
18 years and over
People
24
Run by
Aseel Alsouqi
See details and how to joinNCT05873712
Phase 1Taking people
Tegavivint for Treating Patients With Relapsed or Refractory Large B-Cell Lymphoma
Where
Columbus
Age
18 years and over
People
18
Run by
Lapo Alinari
See details and how to joinNCT05755087
Phase 1Taking people
CC-99282 + Rituximab Early Post CART for Non-Hodgkin's Lymphoma
Where
Columbus
Age
18 years and over
People
18
Run by
Nathan Denlinger
See details and how to joinNCT06209619
Phase 1/2Taking people
CAR-20/19-T Cells in Patients With Relapsed Refractory B Cell Malignancies
Where
Milwaukee
Age
18 years to 80 years
People
100
Run by
Medical College of Wisconsin
See details and how to joinNCT04186520
Phase 1Taking people
Genetically Modified T-cells (CMV-Specific CD19-CAR T-cells) Plus a Vaccine (CMV-MVA Triplex) Following Stem Cell Transplantation for the Treatment of Intermediate or High Grade B-cell Non-Hodgkin Lymphoma
Where
Duarte
Age
18 years and over
People
15
Run by
City of Hope Medical Center
See details and how to joinNCT05432635
Phase 1Taking people
Study of Oral Administration of LP-168 in Patients With Relapsed or Refractory B-cell Malignancies.
Where
Cincinnati, Columbus, Durham, Salt Lake City
Age
18 years and over
People
60
Run by
Newave Pharmaceutical Inc
See details and how to joinNCT04775745
Phase 1Taking people
Study of SGR-1505 in Mature B-Cell Neoplasms
Where
Boston, Buffalo, Canton, Columbus, Dallas, Durham, Gilbert, Hackensack, Milwaukee, Newark, New York, Pompano Beach, Portland, Providence, Seattle, The Bronx
Age
18 years and over
People
98 worldwide
Run by
Schrödinger, Inc.
See details and how to joinNCT05544019 · EU 2023-505204-34-00
Phase 1Taking people
B-Cell Activating Factor Receptor (BAFFR)-Based Chimeric Antigen Receptor T-Cells With Fludarabine and Cyclophosphamide Lymphodepletion for the Treatment of Relapsed or Refractory B-cell Hematologic Malignancies
Where
Jacksonville
Age
18 years and over
People
27
Run by
Mayo Clinic
See details and how to joinNCT06191887
Early phase 1Taking people
Evaluation of Bridging Radiation Therapy Before CAR T-Cell Infusion for the Treatment of Relapsed or Refractory Large B-Cell Lymphoma
Where
Duarte
Age
18 years and over
People
9
Run by
City of Hope Medical Center
See details and how to joinNCT05800405
No phaseTaking people
ctDNA-guided Therapy Optimization in Newly Diagnosed DLBCL
Where
New York
Age
18 years and over
People
40
Run by
Hua-Jay J Cherng, MD
See details and how to joinNCT06693830
Phase 2Taking people
Zanubrutinib in Patients With DLBCL and MYD88 or NOTCH1 Mutation or CD5+
Where
Richmond
Age
18 years and over
People
21
Run by
Virginia Commonwealth University
See details and how to joinNCT06846463
Phase 1Taking people
A Dose Escalation and Dose Expansion Study of Intratumoral ONM-501 Alone and in Combination With Cemiplimab in Patients With Advanced Solid Tumors and Lymphomas.
Where
Canton, Columbus, Dallas, Fairfax, Houston, Los Angeles, Pittsburgh, Tamarac
Age
18 years and over
People
168 worldwide
Run by
OncoNano Medicine, Inc.
See details and how to joinNCT06022029
Phase 2Taking people
A Study of Circulating Tumor DNA (ctDNA) Testing for People With B-Cell Lymphoma
Where
Basking Ridge, Commack, Harrison, Middletown, Montvale, New York, Rockville Centre
Age
18 years and over
People
50
Run by
Memorial Sloan Kettering Cancer Center
See details and how to joinNCT06736613
No phaseTaking people
Long-term Follow-up Study of Patients Receiving CAR-T Cells
Where
Milwaukee
Age
18 years to 80 years
People
500
Run by
Medical College of Wisconsin
See details and how to joinNCT03375619
Phase 2Taking people
A Study to Evaluate the Impact of Mosunetuzumab Consolidation for Older Patients With Diffuse Large B-cell Lymphoma (DLBCL) Who Have Detectable Amounts of ctDNA (Circulating Tumor DNA) at the End of Treatment With Pola-R-mini-CHP
Where
Rochester
Age
70 years and over
People
40
Run by
Danielle Wallace
See details and how to joinNCT06828991
Phase 1Taking people
A Study of AC676 for the Treatment of Relapsed/Refractory B-Cell Malignancies
Where
Chapel Hill, Cleveland, Columbus, Dallas, Denver, Nashville, Portland, Sarasota, Seattle
Age
18 years and over
People
60
Run by
Accutar Biotechnology Inc
See details and how to joinNCT05780034
Phase 1Taking people
A Study of NX-1607 in Adults With Advanced Malignancies
Where
Aurora, Chapel Hill, Charlottesville, Chicago, Duarte, Houston, Los Angeles, Oklahoma City, San Francisco, Seattle
Age
18 years and over
People
345 worldwide
Run by
Nurix Therapeutics, Inc.
See details and how to joinNCT05107674