Diffuse large B-cell lymphoma trials in United States

In United States 131 Also abroad 346

131 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 1Taking people
Feasibility and Safety of Collecting and Combining Autologous Hematopoietic Stem Cells With Chimeric Antigen Receptor (CAR) T-Cell Therapy in Subjects With Relapsed/Refractory Hematological Malignancies
Where
Los Angeles
Age
18 years to 85 years
People
20
Run by
Joshua Sasine, MD, PhD
See details and how to joinNCT05887167
Phase 1Taking people
LV20.19 CAR T-Cells in Combination With Pirtobrutinib for Relapsed, Refractory B-cell Malignancies
Where
Milwaukee
Age
18 years to 81 years
People
12
Run by
Medical College of Wisconsin
See details and how to joinNCT05990465
No phaseTaking people
Sample Collection for Ongoing Research and Product Evaluation Study - Non-Hodgkin Lymphoma (SCORE-NHL)
Where
Austin
Age
18 years and over
People
200
Run by
Natera, Inc.
See details and how to joinNCT07750886
No phaseTaking people
Lentiviral Gene Therapy (Zamtocabtagene Autoleucel) LTFU
Where
Baltimore, Boston, Chicago, Dallas, Durham, Gilbert, Milwaukee, New Haven, Portland, Stanford, Westwood
Age
18 years and over
People
150
Run by
Miltenyi Biomedicine GmbH
See details and how to joinNCT06116110
Phase 2Not yet taking people in United States
Glofitamab in B-NHL Using Mid-Therapy Intratumoral Transcriptomics
Where
New York
Age
18 years and over
People
16
Run by
Joshua Brody
See details and how to joinNCT07748364
Phase 1Not yet taking people in United States
Autologous IC-Nine, CD30 CAR, and Constitutive IL7R Expressing EBVST for CD30 Lymphoma (ANCILE-30)
Where
Houston
Age
16 years to 75 years
People
21
Run by
The Methodist Hospital Research Institute
See details and how to joinNCT07729397
Phase 1Taking people
This is a Phase 1 Study to Evaluate the Safety of LTZ-301 in Patients With Non-Hodgkin Lymphoma
Where
Buffalo, Duarte, Nashville, New York, Seattle, St Louis
Age
18 years and over
People
42
Run by
LTZ Therapeutics, Inc.
See details and how to joinNCT07121946
Phase 1Not yet taking people in United States
Epcoritamab and Pola-R-mini-CHP for the Treatment of Diffuse Large B Cell Lymphoma in Elderly or Unfit Patients
Where
Los Angeles
Age
70 years and over
People
20
Run by
Jonsson Comprehensive Cancer Center
See details and how to joinNCT07714421
Phase 2Not yet taking people in United States
Phase 2 Trial of CD70.CAR NK Cells for Patients With Primary Refractory or Early Relapsed Diffuse Large B-Cell Lymphoma and Hodgkin Lymphoma
Where
Houston
Age
18 years to 75 years
People
100
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT07164469
Phase 2Taking people
DALY II USA/ MB-CART2019.1 for DLBCL
Where
Ann Arbor, Atlanta, Augusta, Baltimore, Birmingham, Boston, Chicago, Columbus, Dallas, Denver, Durham, Gilbert, Houston, La Jolla, Miami, Milwaukee, Nashville, New Haven, New York, Omaha, Phoenix, Pittsburgh, Portland, Rochester, San Antonio, Seattle, Stanford, St Louis, Westwood
Age
18 years and over
People
315 worldwide
Run by
Miltenyi Biomedicine GmbH
See details and how to joinNCT04792489 · EU 2023-508508-39-01
Phase 1Taking people
Immune Cell Therapy (CAR-T) for the Treatment of Patients With HIV and B-Cell Non-Hodgkin Lymphoma
Where
Chicago, Columbus, Duarte, New York, Philadelphia, Salt Lake City, The Bronx
Age
18 years and over
People
20
Run by
AIDS Malignancy Consortium
See details and how to joinNCT05077527
Phase 2Taking people
Odronextamab for the Treatment of Relapsed and Refractory Diffuse Large B-cell Lymphoma Before and After Chimeric Antigen Receptor T-cell Therapy
Where
Sacramento
Age
18 years and over
People
34
Run by
University of California, Davis
See details and how to joinNCT06854159
Phase 1/2Taking people
Mosunetuzumab With Chemotherapy for the Treatment of Patients With Untreated C-Myc Rearrangement Positive High Grade B Cell Lymphoma or Diffuse Large B Cell Lymphoma
Where
Portland
Age
18 years to 75 years
People
40
Run by
OHSU Knight Cancer Institute
See details and how to joinNCT06249191
No phaseTaking people
Evaluation of Human Immune Responses Vaccination in Patients With Lymphoma
Where
Atlanta
Age
18 years and over
People
200
Run by
Emory University
See details and how to joinNCT03501576
Phase 1Taking people
A Study of NX-5948 in Adults With Relapsed/Refractory B-cell Malignancies
Where
Atlanta, Bethesda, Chicago, Cincinnati, Cleveland, Denver, Duarte, Durham, Houston, Ithaca, Miami, Milwaukee, New Haven, New York, Philadelphia, Salt Lake City, San Francisco, Sarasota
Age
18 years and over
People
572 worldwide
Run by
Nurix Therapeutics, Inc.
See details and how to joinNCT05131022 · EU 2023-510541-25-00
Phase 1Taking people
Radiation, Oral Vancomycin, and CAR-T for B-Cell Lymphomas
Where
Philadelphia
Age
18 years and over
People
14
Run by
Abramson Cancer Center at Penn Medicine
See details and how to joinNCT07478848
Phase 2Taking people
Epcoritamab Plus Standard of Care Platinum-Based Chemotherapy and Autologous Hematopoietic Cell Transplant for the Treatment of Relapsed or Refractory Large B-cell Lymphoma
Where
Sacramento
Age
18 years and over
People
25
Run by
University of California, Davis
See details and how to joinNCT06905509
No phaseTaking people
Registry of Older Patients With Cancer
Where
Boone, Chapel Hill, Greenville, Hendersonville, Morehead City, New Bern, Raleigh
Age
65 years and over
People
3,000
Run by
UNC Lineberger Comprehensive Cancer Center
See details and how to joinNCT01137825
No phaseTaking people
Hyperfractionated Dual Equivalent Fractionated Radiation Therapy
Where
New Haven
Age
18 years and over
People
10
Run by
Yale University
See details and how to joinNCT06898905
Phase 1Taking people
External Beam Radiotherapy Followed by Bispecific Antibody Therapy for Relapsed/Refractory DLBCL
Where
Salt Lake City
Age
18 years and over
People
12
Run by
University of Utah
See details and how to joinNCT07528352
Phase 2Taking people
Epcoritamab-CAR T Cells for Large B-cell Lymphomas
Where
Philadelphia
Age
18 years and over
People
31
Run by
Abramson Cancer Center at Penn Medicine
See details and how to joinNCT06458439
Phase 1/2Taking people
IOMAB-CAR-T Followed by CAR-T Cell Therapy in R/R DLBCL
Where
Dallas
Age
18 years and over
People
30
Run by
University of Texas Southwestern Medical Center
See details and how to joinNCT06768905
Phase 1Taking people
Zanubrutinib in Combination With Sonrotoclax for the Treatment of Underrepresented Ethnic and Racial Minorities With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma
Where
Duarte
Age
18 years and over
People
37
Run by
City of Hope Medical Center
See details and how to joinNCT06859008
Phase 1/2Taking people
The OPAL Study: AVM0703 for Treatment of Lymphoid Malignancies
Where
Canton, Chicago, Dallas, Duarte, Los Angeles, Louisville, Memphis, Omaha, Weeki Wachee, Whittier
Age
12 years to 95 years
People
144
Run by
AVM Biotechnology Inc
See details and how to joinNCT04329728
Phase 1/2Taking people
Autologous Stem Cell Transplant Followed by Polatuzumab Vedotin in Patients With B-cell Non-Hodgkin and Hodgkin Lymphoma
Where
Valhalla
Age
12 years to 70 years
People
20
Run by
New York Medical College
See details and how to joinNCT04491370