Epilepsy trials in Spain

In Spain 24 Also abroad 451

24 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 10 November 2026. Ask the study team whether a trial fits you.

Phase 3Taking people
Investigate Efficacy and Safety of Carisbamate as Adjunctive Treatment for Seizures Associated With LGS in Children and Adults
Where
Esplugues de Llobregat, Madrid
Age
4 years to 55 years
People
252 worldwide
Run by
SK Life Science, Inc.
See details and how to joinNCT05219617
Phase 3Taking people
A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures
Where
Madrid
Age
12 years and over
People
160 worldwide
Run by
Xenon Pharmaceuticals Inc.
See details and how to joinNCT05667142 · EU 2022-502286-16-00
Phase 3Taking people
A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures (X-TOLE3)
Where
Barakaldo, Madrid
Age
18 years and over
People
360 worldwide
Run by
Xenon Pharmaceuticals Inc.
See details and how to joinNCT05716100 · EU 2022-502281-25-00
Phase 3Enrolling by invitation
An Open-label Study of XEN1101 in Epilepsy
Where
Barakaldo, Barcelona, Madrid, Málaga, Valencia, Valladolid
Age
12 years and over
People
880 worldwide
Run by
Xenon Pharmaceuticals Inc.
See details and how to joinNCT05718817 · EU 2022-502282-24-00
No phaseTaking people
Multi-biomarkers in DEE
Where
Barcelona
Age
0 years to 55 years
People
200 worldwide
Run by
Istituto Giannina Gaslini
See details and how to joinNCT07909382
Phase 3Taking people
Open Label Extension Clinical Trial of Vormatrigine in Adult Patients with Epilepsy.
Where
Barcelona, Granada, Lugo, Madrid, Málaga, Santiago de Compostela, Sevilla, Terrassa, Valencia, Valladolid
Age
18 years and over
People
56 worldwide
Run by
Praxis Precision Medicines Inc.
See details and how to join2025-521640-38-00 · EU 2025-521640-38-00
Phase 3Taking people
A Study of EPX-100 (Clemizole Hydrochloride) in Participants With Dravet Syndrome
Where
Barcelona, Madrid
Age
2 years and over
People
150 worldwide
Run by
Epygenix
See details and how to joinNCT04462770 · EU 2024-518628-57-00
No phaseTaking people
Artificial Intelligence for Brain MRI Analysis in Epilepsy
Where
Barcelona
People
2,000 worldwide
Run by
Istituto Giannina Gaslini
See details and how to joinNCT07881185
Phase 3Enrolling by invitation
A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathy (DEE)
Where
Barcelona, Esplugues de Llobregat, Madrid, Málaga, Pamplona, Valencia
Age
2 years to 66 years
People
324 worldwide
Run by
Longboard Pharmaceuticals
See details and how to joinNCT06908226 · EU 2024-514974-39-00
Phase 3Taking people
Efficacy and Safety Study of Once-Daily Extended-Release Levetiracetam in Drug-resistant Focal Onset Seizures
Where
Barcelona, Madrid, Málaga, Santiago de Compostela
People
134 worldwide
Run by
Neuraxpharm Pharmaceuticals S.L.
See details and how to join2024-514499-42-00 · EU 2024-514499-42-00
Phase 1/2Taking people
A First-in-human Study of S230815 in Pediatric Participants With KCNT1-related Developmental and Epileptic Encephalopathy
Where
Esplugues de Llobregat, Madrid
Age
2 years to 12 years
People
20 worldwide
Run by
Institut de Recherches Internationales Servier
See details and how to joinNCT07227857 · EU 2024-513332-17-00
Phase 3Taking people
An Efficacy and Safety Study of Clemizole HCl in Patients With Lennox-Gastaut Syndrome
Where
Barcelona, Madrid, Málaga, Pamplona, Seville
Age
2 years to 55 years
People
260 worldwide
Run by
Epygenix
See details and how to joinNCT05066217
No phaseTaking people
Prospective Natural History Study of POLG Disease
Where
Madrid
People
300 worldwide
Run by
The POLG Foundation
See details and how to joinNCT07775872
Phase 3Enrolling by invitation
Clinical Trial of Vormatrigine in Adult Patients With Epilepsy
Where
Barcelona, Madrid, Málaga, Terrassa, Valencia
Age
18 years to 85 years
People
700 worldwide
Run by
Praxis Precision Medicines
See details and how to joinNCT07287163
No phaseTaking people
SLC6A1-NDD Prospective Longitudinal Natural History Study
Where
Madrid
Age
Up to 17 years
People
60 worldwide
Run by
UCB Biopharma SRL
See details and how to joinNCT07531511
Phase 3Taking people
A Study to Test the Safety and Tolerability of Brivaracetam in Children and Adolescents With Seizures
Where
Seville
Age
1 month and over
People
70 worldwide
Run by
UCB Biopharma SRL
See details and how to joinNCT04715646
No phaseEnrolling by invitation
5-SENSE Score Validation Study
Where
Valencia
Age
15 years and over
People
400 worldwide
Run by
Duke University
See details and how to joinNCT06138808
Phase 2Enrolling by invitation
Long-term Safety and Tolerability of BHV-7000
Where
Badalona, Barcelona, Granada, L'hospitalet De Llobregat, Madrid, Málaga, Pamplona, Sevilla, Terrassa, Valencia, Valladolid, Vigo
Age
18 years to 75 years
People
660 worldwide
Run by
Biohaven Therapeutics Ltd.
See details and how to joinNCT06443463 · EU 2023-508813-18-00
Phase 3Taking people
Treatment With Full-spectrum Cannabis Extract of Refractory Epilepsy Associated With Tuberous Sclerosis Complex (TSC)
Where
Barcelona, Madrid
Age
2 years to 65 years
People
84
Run by
Oils4Cure
See details and how to joinNCT07403266 · EU 2024-520171-27-00
Phase 3Taking people
LEvetiracetam to Prevent Seizures in Symptomatic Alzheimer's Disease in Adults With Down Syndrome
Where
Barcelona, Donostia, Granada, Madrid, Santander
Age
40 years and over
People
120
Run by
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
See details and how to joinNCT07234695 · EU 2024-516148-24-00
No phaseTaking people
REACH: RWE Retrospective Study to Evaluate Cenobamate Impact on Health Care Resource Utilization
Where
Barcelona, Madrid, Valencia
Age
18 years and over
People
200 worldwide
Run by
Aziende Chimiche Riunite Angelini Francesco S.p.A
See details and how to joinNCT06922175
Phase 2Taking people
An Open Label Trial to Evaluate the Efficacy and Safety of PRAX-628 in Adults With Focal Onset or Tonic-Clonic Seizures
Where
Madrid
Age
18 years to 75 years
People
50 worldwide
Run by
Praxis Precision Medicines
See details and how to joinNCT06908356
Phase 1Taking people
Phase I, open-label clinical trial to evaluate the safety and clinical response of repeated-dose intra-arterial infusion of autologous mesenchymal cells in children and adolescents with refractory epilepsies.
Where
Madrid
Age
Up to 17 years
People
10
Run by
Fundacion Para La Investigacion Biomedica Del Hospital Universitario La Princesa
See details and how to join2024-520427-86-00 · EU 2024-520427-86-00
No phaseNot yet taking people in Spain
Phenotyping and Identification of Biological Markers in STXBP1 Encephalopathy
Where
Madrid
Age
1 month to 10 years
People
10
Run by
Fundación Iniciativa para las Neurociencias (FINCE)
See details and how to joinNCT06356233