Epilepsy: open trials in United States
199 open trials have a site in United States. Registry data; only the trial team decides who can take part.
NCT00060541
Evaluation and Treatment of Neurosurgical Disorders
Research · National Institute of Neurological Disorders and Stroke (NINDS)
National Institutes of Health Clinical Center, Bethesda
Registry updated 2026-11-03
NCT02824822
Registry updated 2026-11-03
NCT05667142
A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures
Trial Treatment · Phase 3 · Xenon Pharmaceuticals Inc.
Summa Health Clinical Research Center, Akron · Dent Neurosciences Research Facility, Amherst · University of Michigan Hospitals, Ann Arbor · Emory Brain Health Center, Atlanta · Children's Healthcare of Atlanta, Atlanta · University of Colorado Anschutz Medical Campus, Aurora · Child Neurology Consultants of Austin, Austin · University of Maryland Medical Center, Baltimore · MedStar Franklin Square Medical Center, Baltimore · Mid-Atlantic Epilepsy and Sleep Center, Bethesda · Consultants in Epilepsy and Neurology PLLC, Boise · Boys Town National Research Hospital, Boys Town · Medical University of South Carolina (MUSC), Charleston · Atrium Health, Charlotte · Onsite Clinical Solutions, LLC, Charlotte · Brigham and Women's Hospital, Chestnut Hill · Cleveland Clinic Foundation, Cleveland · Medstar Georgetown University Hospital, Clinton · The Ohio State University, Columbus · OhioHealth Riverside Methodist Hospital, Columbus · Wayne State University, Detroit · Duke University Clinical Research, Durham · Michigan State University Department of Neurology, East Lansing · ANESC Research, El Paso · Spectrum Health, Grand Rapids · Northeast Regional Epilepsy Group, Hackensack · Hawaii Pacific Neuroscience, Comprehensive Epilepsy Center, Honolulu · UTHealth Science Center at Houston, Houston · Indiana University School of Medicine, Indianapolis · Mayo Clinic Florida, Jacksonville · University of Kansas Medical Center, Kansas City · University of Kentucky Albert B. Chandler Hospital (UK Healthcare), Lexington · Bluegrass Epilepsy Research, LLC, Lexington · University of Arkansas for Medical Sciences, Little Rock · Brain Science Research Institute, Los Angeles · Serenity Research Center, LLC, Miami · Advocate Aurora Research institute, St. Luke's Medical Center, Milwaukee · University of Alabama - Strada Patient Care Center, Neurology, Mobile · University of California, Irvine - Health Neurology Services, Orange · Orlando Health Neuroscience Institute, Orlando · Research Institute of Orlando LLC, Orlando · Panhandle Research and Medical Clinic, Pensacola · University of Pennsylvania, Philadelphia · Temple University Hospital, Philadelphia · Xenoscience, Phoenix · UPMC Comprehensive Epilepsy Center, Pittsburgh · Medsol Clinical Research Center Harbor Professional Centre, Port Charlotte · University California, Davis Clinical & Translation Science Center Clinical Research (CCRC), Sacramento · University of Utah Clinical Neurosciences Center, Salt Lake City · University of Texas Health Science Center at San Antonio, San Antonio · University of Washington, Regional Epilepsy Center at Harborview Medical Center, Seattle · Southern Illinois University School of Medicine, Springfield · Saint Louis University Medical School, St Louis · Georgia Neurology & Sleep Medicine Associates, Suwanee · SUNY Upstate Medical University, Syracuse · University of South Florida, Tampa · University of Arizona - Health Science Center, Tucson · Sentara Neurology Specialists, Virginia Beach · Encore Medical Research of Weston, LLC, Weston · Wake Forest Baptist Health, Winston-Salem · Five Towns Neurology, Woodmere · Umass Memorial Medical Center, Worcester
Registry updated 2026-11-02
NCT05716100
A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures (X-TOLE3)
Trial Treatment · Phase 3 · Xenon Pharmaceuticals Inc.
Austin Epilepsy Care Center, Austin · Mid-Atlantic Epilepsy and Sleep Center, Bethesda · Consultants in Epilepsy and Neurology PLLC, Boise · Cleveland Clinic, Cleveland · OhioHealth, Columbus · 9D University Health Center, Detroit · Rancho Research Institute, Downey · Duke University Clinic, Durham · Panhandle Research and Medical Clinic, Gulf Breeze · Northeast Regional Epilepsy Group, Hackensack · Mayo Clinic Florida, Jacksonville · Clinical Trials Inc., Little Rock · University of California Los Angeles (UCLA)., Los Angeles · Vanderbilt University Medical Center, Nashville · University of California, Irvine Health, Orange · Providence Neurological Specialities, Portland · University of Utah Clinical Neurosciences Center, Salt Lake City · Southern Illinois University School of Medicine, Springfield · Five Towns Neuroscience Research, Woodmere
Registry updated 2026-11-02
NCT05718817
An Open-label Study of XEN1101 in Epilepsy
Trial Treatment · Phase 3 · Xenon Pharmaceuticals Inc.
Summa Health, Akron · University of Michigan Hospitals, Ann Arbor · University of Colorado Hospital - Anschutz Outpatient Pavilion, Aurora · Austin Epilepsy Care Center, Austin · University of Maryland Medical Center, Baltimore · Mid-Atlantic Epilepsy and Sleep Center, Bethesda · Consultants in Epilepsy and Neurology, Boise · Brigham and Women's Hospital, Boston · Dent Neurosciences Research Center, Buffalo · Minneapolis Clinic of Neurology, Burnsville · OnSite Clinical Solutions, Charlotte · Cleveland Clinic Foundation, Cleveland · The Ohio State University Brain and Spine Hospital, Columbus · Wayne State University, Detroit · Duke University, Durham · Michigan State University, East Lansing · ANESC Research, El Paso · Cornwell Health (Spectrum Health Hospitals), Grand Rapids · Northeast Epilepsy Group, Hackensack · Hawaii Pacific Neuroscience, Honolulu · Indiana University School of Medicine, Indianapolis · Mayo Clinic Florida, Jacksonville · The University of Kansas Medical Center, Kansas City · Kentucky Clinic, Lexington · Bluegrass Epilepsy Research, LLC, Lexington · Clinical Trials Inc., Little Rock · Brain Science Research Institute, Los Angeles · Serenity Research Center, LLC, Miami · Aurora St. Luke's Medical Center, Milwaukee · Vanderbilt University Medical Center, Nashville · Mount Sinai Health, New York · New York University Comprehensive Epilepsy Center, New York · UC Irvine Health, Orange · Research Institute of Orlando LLC, Orlando · Panhandle Research & Medical Clinic, Pensacola · University of Pennsylvania, Philadelphia · Thomas Jefferson University, Philadelphia · Xenoscience, Phoenix · Providence Neurological Specialities, Portland · Meridian Clinical Research, LLC, Raleigh · Carilion Clinic, Roanoke · University of California, Davis Clinical & Translational Science Center Clinical Research (CCRC), Sacramento · University of Utah Clinical Neurosciences Center, Salt Lake City · UT Health San Antonio, San Antonio · MMP Neurology, Scarborough · University of Washington Main Hospital, Seattle · Saint Louis University Medical School, St Louis · SUNY Upstate Medical University, Syracuse · University of South Florida, Tampa · Montefiiore Medical Center, The Bronx · University of Arizona - Health Sciences, Tucson · Sentara Neurology Specialists, Virginia Beach · Encore Medical Research of Weston, LLC, Weston · UMass Chan Medical School, Worcester
Registry updated 2026-11-02
NCT05989893
Mapping of Human Cognition
Trial Treatment · The University of Texas Health Science Center, Houston
The University of Texas Health Science Center at Houston, Houston
Registry updated 2026-11-02
NCT07531745
ASCEND: Safety and Tolerability of ION337 for the Treatment of Dravet Syndrome
Trial Treatment · Phase 1/2 · Ionis Pharmaceuticals, Inc.
University of Michigan Health System, Ann Arbor · Duke University Health Systems, Durham · Le Bonheur Children's Hospital, Memphis · The Children's Hospital of Philadelphia (CHOP), Philadelphia · Mayo Clinic, Rochester · Seattle Children's Hospital, Seattle
Registry updated 2026-11-02
NCT07723963
A Study to Evaluate the Safety and Efficacy of JZP926 Capsule for the Treatment of Juvenile Myoclonic Epilepsy
Trial Treatment · Phase 2/3 · Jazz Pharmaceuticals
Emory Healthcare, Atlanta · Consultants in Epilepsy and Neurology, Boise · Northwesthern Medicine, Chicago · Cincinnati Children's Hospital, Cincinnati · Scottish Rite Hospital, Dallas · Corewell Health, Grand Rapids · Boston Children's Health Physicians, Hawthorne · Hawaii Pacific Neuroscience LLC, Honolulu · Northwell Health - Division of Pediatric Neurology, Lake Success · Bluegrass Epilepsy Research, Lexington · UCLA Mattel Children's Hospital, Los Angeles · Saint Peter's University Hospital, New Brunswick · Yale University, New Haven · Weill Cornell Medicine - Pediatric Neurology, New York · Children's Hospital of Philadelphia, Philadelphia · Banner University Medical Center, Phoenix · Oregon Health Science University, Portland · Carilion Clinic Neurology, Roanoke · Sutter Health, Sacramento · Savannah Neurology Specialists, Savannah · Pediatric Epilepsy & Neurology Specialists, Tampa · Sentara Neurology Specialists, Virginia Beach · Winchester Neurological Consultants, Winchester
Registry updated 2026-11-02
NCT07735715
HOBSCOTCH-YOUTH and Young Adults
Trial Treatment · Dartmouth-Hitchcock Medical Center
Dartmouth Hitchcock, Lebanon
Registry updated 2026-11-02
NCT05135091
Study of NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (EPIC (EPIlepsy Cell Therapy))
Trial Treatment · Phase 3 · Neurona Therapeutics
University of Colorado Anschutz Medical Campus, Aurora · University of Alabama, Birmingham · Beth Israel Deaconess Medical Center, Boston · Kaleida Health, Buffalo · Atrium Health, Charlotte · University of Chicago, Chicago · Rush University Medical Center, Chicago · UT Southwestern Medical Center, Dallas · Wayne State University/Detroit Medical Center Comprehensive Epilepsy Program, Detroit · Duke University Hospital, Durham · Hofstra Northwell Comprehensive Epilepsy Center, Great Neck · UTHealth Houston, Houston · University of Iowa Health Care, Iowa City · Dartmouth Hitchcock Medical Center/ Department of Neurology, Lebanon · University of Arkansas for Medical Sciences, Little Rock · University of Southern California Keck Hospital, Los Angeles · University of California, Los Angeles, Los Angeles · University of Miami, Miami · Medical College of Wisconsin, Milwaukee · Ochsner Clinic Foundation, New Orleans · NYU Langone Comprehensive Epilepsy Center, New York · UC Irvine Medical Center, Orange · Stanford University, Palo Alto · Thomas Jefferson University Hospital, Philadelphia · Mayo Clinic Arizona Epilepsy Center, Phoenix · Oregon Health and Science University, Portland · University of California - Davis, Sacramento · University Of Utah Health, Salt Lake City · University of California San Diego, San Diego · University of California San Francisco, San Francisco · University of Washington Regional Epilepsy Center, Seattle · Washington University at St. Louis, St Louis · SUNY Upstate Medical University, Syracuse · Banner-University of Arizona Medical Center Tucson Comprehensive Epilepsy Program, Tucson · George Washington University, Washington D.C. · Atrium Wake Forest Baptist, Winston-Salem
Registry updated 2026-10-30
NCT07520955
Lily's Grace Temporal Interference
Trial Treatment · University of Wisconsin, Madison
UW School of Medicine and Public Health, Madison
Registry updated 2026-10-30
NCT02531880
Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy
Trial Treatment · Phase 1 · National Institute of Neurological Disorders and Stroke (NINDS)
National Institutes of Health Clinical Center, Bethesda
Registry updated 2026-10-29
NCT04462770
A Study of EPX-100 (Clemizole Hydrochloride) in Participants With Dravet Syndrome
Trial Treatment · Phase 3 · Epygenix
University of Michigan/Mott Children's Hospital, Ann Arbor · Clinical Integrative Research Center of Atlanta (CIRCA), Atlanta · Child Neurology Consultants of Austin, Austin · University of Alabama at Birmingham, Birmingham · Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago · Cincinnati Children's Hospital Medical Center, Cincinnati · Cleveland Clinic, Cleveland · Nationwide Children's Hospital, Columbus · UT Southwestern/Children's Health, Dallas · Duke University Health System, Durham · Northeast Regional Epilepsy Group, Hackensack · Rare Disease Research FL, Kissimmee · Arkansas Children's Hospital, Little Rock · Children's Hospital of Los Angeles, Los Angeles · Norton Children's Research Institute, Louisville · Neurology Center for Epilepsy and Seizures, Marlboro · Le Bonheur Children's Hospital, Memphis · Medical College of Wisconsin, Children's Wisconsin, Milwaukee · Science 37, Morrisville · Yale School of Medicine - Yale-New Haven Hospital, New Haven · Northwell Health- Lenox Hill Hospital, New York · Weill Cornell Medical Center, New York · Children's Nebraska, Omaha · University of California Irvine, Orange · The Children's Hospital Of Philadelphia, Philadelphia · University of Utah, Salt Lake City · UCSF Medical Center, San Francisco · Seattle Children's Hospital, Seattle · The Nemours Foundation, Wilmington · Wake Forest Baptist Medical Center, Winston-Salem · Pediatric Neurology and Epilepsy Specialists, Winter Park
Registry updated 2026-10-29
NCT01793168
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
Research · Sanford Health
Sanford Health, Sioux Falls
Registry updated 2026-10-28
NCT06974305
PET/MRI/EEG Imaging Study in Epilepsy
Research · Massachusetts General Hospital
Athinoula A. Martinos Center, Charlestown
Registry updated 2026-10-28
NCT07803692
High-Intensity Focused Ultrasonic Ablation of the Centromedian Thalamic Nucleus for Treatment of Medically Refractory Generalized Epilepsy in Patients Ages 18 Years to 89 Years
Trial Treatment · Oregon Health and Science University
Oregon Health Science University, Portland
Registry updated 2026-10-28
NCT04095026
Study of Direct Brain Recording and Stimulation for Memory Enhancement
Research · National Institute of Neurological Disorders and Stroke (NINDS)
National Institutes of Health Clinical Center, Bethesda
Registry updated 2026-10-27
NCT05944692
Epilepsy Seizure Detection With Innovative Tripolar EEG (tEEG)
Research · CREmedical
Boston Children's Hospital, Boston · Barrow Neurological Institute Dignity Health dba St. Joseph's Hospital and Medical Center, Phoenix
Registry updated 2026-10-27
NCT07141329
SPN-817 Open-Label Extension Study in Adults With Focal Onset Seizures
Trial Treatment · Phase 2 · Supernus Pharmaceuticals, Inc.
Asheville Neurology Specialists, Asheville · Ilumina Medical Research, Kissimmee · Thomas Jefferson University, Philadelphia · Medsol Clinical Research Center, Port Charlotte · University of Rochester Medical Center, Rochester · Center for Neurosciences, Tucson · Focus Clinical Research, West Hills
Registry updated 2026-10-27
NCT00859794
An Examination of Cognitive and Sensorimotor Processes in Patients With Epilepsy
Trial Treatment · Northwell Health
Comprehensive Epilepsy Care Center, Great Neck
Registry updated 2026-10-26
NCT01273129
Surgery as a Treatment for Medically Intractable Epilepsy
Research · National Institute of Neurological Disorders and Stroke (NINDS)
National Institutes of Health Clinical Center, Bethesda
Registry updated 2026-10-26
NCT02639325
Tumor Related Epilepsy
Research · National Institute of Neurological Disorders and Stroke (NINDS)
National Institutes of Health Clinical Center, Bethesda
Registry updated 2026-10-26
NCT03478852
Investigating Epilepsy: Screening and Evaluation
Research · National Institute of Neurological Disorders and Stroke (NINDS)
National Institutes of Health Clinical Center, Bethesda
Registry updated 2026-10-26
NCT06617845
Optimizing Brain Stimulation Parameters
Trial Treatment · Mayo Clinic
Mayo Clinic - Rochester, Rochester
Registry updated 2026-10-26
NCT07110337
Diagnosing Epilepsy To EffeCT Change
Trial Treatment · Epiminder America, Inc.
Michigan Medicine, Ann Arbor · Billings Clinic, Billings · UAB Epilepsy Center, Birmingham · Massachusetts General Hospital, Boston · Beth Israel Deaconess Medical Center, Boston · Atrium Health Neurosciences Institute ? Charlotte, Charlotte · University Hospitals Cleveland Medical Center, Clevland · UT Southwestern Medical Center, Dallas · Duke University, Durham · University of Texas Health Science Center at Houston, Houston · IU Health Neuroscience Center, Indianapolis · University of California, Irvine Medical Center, Irvine · Mayo Clinic Florida, Jacksonville · Nicklaus Children's Hospital, Miami · University of Minnesota, Minneapolis · Yale School of Medicine, New Haven · Stanford, Palo Alto · University of Pennsylvania, Philadelphia · Mayo Clinic - Arizona, Phoenix · Mayo Clinic - Rochester, Rochester · UC San Diego Health, San Diego · Washington University, St Louis · USF Health, Tampa
Registry updated 2026-10-26
All Epilepsy trials and the map
This page is not medical advice. Talk to your doctor before contacting a trial.