Epilepsy: open trials in United States

208 open trials have a site in United States. Registry data; only the trial team decides who can take part.

NCT01273129
Surgery as a Treatment for Medically Intractable Epilepsy
Research · National Institute of Neurological Disorders and Stroke (NINDS)
National Institutes of Health Clinical Center, Bethesda
Registry updated 2026-10-26
NCT03478852
Investigating Epilepsy: Screening and Evaluation
Research · National Institute of Neurological Disorders and Stroke (NINDS)
National Institutes of Health Clinical Center, Bethesda
Registry updated 2026-10-26
NCT06617845
Optimizing Brain Stimulation Parameters
Trial Treatment · Mayo Clinic
Mayo Clinic - Rochester, Rochester
Registry updated 2026-10-26
NCT07110337
Diagnosing Epilepsy To EffeCT Change
Trial Treatment · Epiminder America, Inc.
Michigan Medicine, Ann Arbor · Billings Clinic, Billings · UAB Epilepsy Center, Birmingham · Massachusetts General Hospital, Boston · Beth Israel Deaconess Medical Center, Boston · Atrium Health Neurosciences Institute ? Charlotte, Charlotte · University Hospitals Cleveland Medical Center, Clevland · UT Southwestern Medical Center, Dallas · Duke University, Durham · University of Texas Health Science Center at Houston, Houston · IU Health Neuroscience Center, Indianapolis · University of California, Irvine Medical Center, Irvine · Mayo Clinic Florida, Jacksonville · Nicklaus Children's Hospital, Miami · University of Minnesota, Minneapolis · Yale School of Medicine, New Haven · Stanford, Palo Alto · University of Pennsylvania, Philadelphia · Mayo Clinic - Arizona, Phoenix · Mayo Clinic - Rochester, Rochester · UC San Diego Health, San Diego · Washington University, St Louis · USF Health, Tampa
Registry updated 2026-10-26
NCT05419492
A Clinical Study to Evaluate the Safety and Efficacy of ETX101 in Infants and Children With SCN1A-Positive Dravet Syndrome
Trial Treatment · Phase 1/2 · Encoded Therapeutics
Mott Children's Hospital, Ann Arbor · Colorado Children's Hospital, Aurora · Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago · Nationwide Children's Hospital, Columbus · Duke Children's Hospital & Health Center, Durham · Cook Children's Medical Center, Fort Worth · Nicklaus Children's Hospital, Miami · NYU Langone Health, New York · Oregon Health and Science university (OHSU), Portland · Mayo Clinic, Rochester · UCSF Benioff Children's Hospitals, San Francisco
Registry updated 2026-10-23
NCT07110454
Diagnosing Epilepsy To EffeCT Change Long-Term Follow-Up
Research · Epiminder America, Inc.
Michigan Medicine, Ann Arbor · Billings Clinic, Billings · UAB Epilepsy Center, Birmingham · Massachusetts General Hospital, Boston · Beth Israel Deaconess Medical Center, Boston · Atrium Health Neurosciences Institute ? Charlotte, Charlotte · University Hospitals Cleveland Medical Center*, Cleveland · Duke University, Durham · IU Health Neuroscience Center, Indianapolis · Mayo Clinic Florida, Jacksonville · Nicklaus Children's Hospital, Miami · University of Minnesota, Minneapolis · Yale School of Medicine, New Haven · Stanford, Palo Alto · University of Pennsylvania, Philadelphia · Mayo Clinic - Arizona, Phoenix · Mayo Clinic - Rochester, Rochester · UC San Diego Health, San Diego · Washington University, St Louis · USF Health, Tampa
Registry updated 2026-10-22
NCT07728097
A Study to Investigate the Effect of Gradual Titration to Optimize Cannabidiol Treatment in Adults With LGS
Trial Treatment · Phase 4 · Jazz Pharmaceuticals
Neuro Pain Research Center, Fresno · Louisiana State University Health Sciences Center- New Orleans, New Orleans · Velocity Clinical Research at Raleigh Neurology, Raleigh
Registry updated 2026-10-22
NCT07883720
EXercise-induced PhysioLogical Adaptations In Neurological Disorders
Trial Treatment · Brigham and Women's Hospital
Brigham and Women's Hospital, Boston
Registry updated 2026-10-20
NCT02107989
Noninvasive Pre-surgical Evaluation of Patients With Focal Epilepsy and Establishment of a Normative Imaging Database
Research · National Institute of Neurological Disorders and Stroke (NINDS)
National Institutes of Health Clinical Center, Bethesda
Registry updated 2026-10-19
NCT06369571
Improving Cardiovascular Health Risks in Adults With Epilepsy on a Modified Atkins Diet
Trial Treatment · Phase 1/2 · Johns Hopkins University
Johns Hopkins Hospital, Baltimore
Registry updated 2026-10-19
NCT06545643
Sleep-Sensitive Seizure Risk Assessment With Wearable EEGs
Trial Treatment · Duke University
Duke University Health System, Durham
Registry updated 2026-10-19
NCT07881185
Artificial Intelligence for Brain MRI Analysis in Epilepsy
Research · Istituto Giannina Gaslini
National Institute of Health (NINDS-Intramural), Bethesda · Medical University of South Carolina, Charleston · Rush Hospital, Chicago · University of California, Oakland · University of Pennsylvania, Philadelphia · George Washington University, Washington D.C.
Registry updated 2026-10-19
NCT05493722
Optimization of Deep Brain Stimulation Parameters in Patients With Medically Refractory Epilepsy
Trial Treatment · Early phase 1 · University of Minnesota
University of Minnesota, Minneapolis
Registry updated 2026-10-16
NCT07434986
Overnight TI in TLE
Trial Treatment · Duke University
Anphy Lab - Inside Hock Plaza, Durham
Registry updated 2026-10-16
NCT07546253
Post-Market Real-World Evidence Registry for the NeuroOne OneRF® Ablation System for Epilepsy
Research · NeuroOne Medical Technologies Corporation
Cooperman Barnabas Medical Center - 94 Old Short Hills Rd, Livingston · Nicklaus Children's Hospital, Miami · Robert Wood Johnson University Hospital - 1 Robert Wood Johnson Pl, New Brunswick
Registry updated 2026-10-16
NCT07600736
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Clinical Activity of ABS-1230 in Pediatric and Young Adult Participants With KCNT1-related Epilepsy
Trial Treatment · Phase 2 · Actio Biosciences, Inc.
Northeast Regional Epilepsy Group, Hackensack · University of Rochester Medical Center, Rochester
Registry updated 2026-10-15
NCT07764718
Temporal Interference Brain Stimulation for Adults With Drug-Resistant Epilepsy Undergoing Stereo-EEG Monitoring
Trial Treatment · Duke University
Duke University Medical Center, Durham
Registry updated 2026-10-15
NCT06598189
Ear-Seizure Detection (EarSD) Study
Trial Treatment · Felicia Chu
Ummmc-Memorial Campus, Worcester · Ummmc-University Campus, Worcester
Registry updated 2026-10-14
NCT06908226
A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathy (DEE)
Trial Treatment · Phase 3 · Longboard Pharmaceuticals
Children's Hospital Colorado - Heart Institute, Aurora · Child Neurology Consultants of Austin - Austin, Austin · Mid-Atlantic Epilepsy and Sleep Center - Bethesda, Bethesda · Consultants in Epilepsy & Neurology, PLLC, Boise · Massachusetts General Hospital (MGH), Boston · NW FL Clinical Research Group, LLC, Gulf Breeze · The University of Texas Medical School at Houston - UT Gastroenterology, Houston · University of Iowa Health Care Medical Center (University of Iowa Hospitals & Clinics), Iowa City · Arkansas Children's Hospital - Cardiology Clinic, Little Rock · Barnabas Health - Institute of Neurology and Neurosurgery, Livingston · University of California Los Angeles (UCLA) - David Geffen School of Medicine - Global Health Pro..., Los Angeles · University of Miami Medical Group (UMMG), Miami · Northeast Regional Epilepsy Group - Morristown, Morristown · NYU Langone Health-NYU Comprehensive Epilepsy Center, New York · Research Institute of Orlando LLC, Orlando · Stanford University - Stanford School of Medicine - Pulmonary and Cystic Fibrosis Center, Palo Alto · Oregon Health & Science University - Blood Brain Barrier and Neuro-Oncology Program, Portland · Mayo Clinic - Children's Center - Rochester, Rochester · UCSF Benioff Children's Hospitals - San Francisco, San Francisco · Pediatric Epilepsy & Neurology Specialists (PENS), Tampa · University of South Florida (USF) - Tampa Campus, Tampa
Registry updated 2026-10-14
NCT04677751
Clinical and Electrographic Changes in Responsive Neurostimulation System (RNS) Patients With Acupuncture Treatment
Trial Treatment · The University of Texas Health Science Center, Houston
The University of Texas Health Science Center at Houston, Houston
Registry updated 2026-10-13
NCT07227857
A First-in-human Study of S230815 in Pediatric Participants With KCNT1-related Developmental and Epileptic Encephalopathy
Trial Treatment · Phase 1/2 · Institut de Recherches Internationales Servier
Boston Children's Hospital, Boston · Nationwide Children's Hospital, Columbus · Children's Hospital of Orange County, Orange · The Children's Hospital Of Philadelphia, Philadelphia · University of Rochester Medical Center, Rochester
Registry updated 2026-10-13
NCT05066217
An Efficacy and Safety Study of Clemizole HCl in Patients With Lennox-Gastaut Syndrome
Trial Treatment · Phase 3 · Epygenix
On-Site Clinical Solution, Charlotte · Atrium Health STRIVE Research, Charlotte · Re:Cognition Health, Chicago · Children's Health Specialty Center, Dallas · Henry Ford Hospital, Detroit · Duke University Medical Center, Durham · UTHealth Houston, Houston · Arkansas Children's Hospital, Little Rock · Norton Children's Medical Center, Louisville · Tekton Research, Marlboro · University of Miami Miller School of Medicine, Miami · PPD Virtual-Science 37, Inc., Morrisville · NYU Comprehensive Epilepsy Center - BRANY - PPDS, New York · Weill Cornell Medicine-New York Presbyterian Hospital, New York · Children's Nebraska, Omaha · UC Irvine Medical Center, Orange · Rare Disease Research, Orlando · AdventHealth Innovation Tower, Orlando · Children's Hospital of Philadelphia, Philadelphia · Minnesota Epilepsy Group, P.A., Roseville · Clinical Neurosciences Center, Salt Lake City · Pediatric Neurology and Epilepsy Specialists, Winter Park
Registry updated 2026-10-09
NCT07225231
Clinical Utility of Reduced EEG Home Monitoring in Fenfluramine Titration for Dravet and LGS
Trial Treatment · Byteflies
Child Neurology Consultants of Austin, Austin · Norton Children's Research Institute - University of Louisville School of Medicine, Louisville · MultiCare Mary Bridge Children's Hospital and Health System, Tacoma
Registry updated 2026-10-08
NCT07350551
Pediatric Epilepsy
Trial Treatment · University of Texas Southwestern Medical Center
Children's Medical Center Dallas, Dallas
Registry updated 2026-10-06
NCT05594017
Pharmacological Modulation of Brain Oscillations in Memory Processing
Trial Treatment · Early phase 1 · University of Texas Southwestern Medical Center
University of Texas Southwestern Medical Center, Dallas
Registry updated 2026-10-05

All Epilepsy trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

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